Incidence and Risk Factors of Post COVID-19 Condition: A Cross-sectional Study

Authors

  • Sirin Natanant Department of Pharmacy and Consumer Protection, Nong Mamong Hospital, Chai Nat, Thailand
  • Pongpan Suriyong Faculty of Pharmaceutical Sciences, Burapha University, Chon Buri, Thailand

DOI:

https://doi.org/10.33165/rmj.2023.46.1.260117

Keywords:

Post COVID-19, Incidence, Risk factor, Community pharmacist role

Abstract

Background: Coronavirus 2019 (COVID-19) infection has caused the survivors to be affected by post COVID-19 conditions in both short- and long-term periods.

Objectives: To determine the incidence and related factors of post COVID-19 condition, and to explore the medication use in the treatment of post COVID-19.

Methods: This study was a cross-sectional study collecting data of 260 patients diagnosed with COVID-19, using random sampling method, between April 3, 2020, and May 31, 2022, from the administration database of Nong Mamong Hospital, Chai Nat, Thailand, and telephone interviews with patients. Data were analyzed using logistic regression.

Results: The study found a post COVID-19 incidence of 79.2% (206 cases). Females had 2.5 times higher chance of developing post COVID-19 than males (95% CI, 1.35 - 4.64, P < .05). Favipiravir, Andrographis paniculate, and COVID-19 vaccination were not associated with the development of post COVID-19 (P > .05). Among those post COVID-19 case, 49% (101 cases) used medications or vitamins to treat or relieve symptoms.

Conclusions: The vast majority of people infected with COVID-19 faced post COVID-19 symptoms, which were more common in females than males.

 

References

World Health Organization. Responding to community spread of COVID-19: interim guidance. March 7, 2020. Accessed September 22, 2022. https://apps.who.int/iris/handle/10665/331421

Pollard CA, Morran MP, Nestor-Kalinoski AL. The COVID-19 pandemic: a global health crisis. Physiol Genomics. 2020;52(11):549-557. doi:10.1152/physiolgenomics.00089.2020

World Health Organization. WHO Coronavirus (COVID-19) Dashboard. June 29, 2022. Accessed September 22, 2022. https://covid19.who.int

Montenegro P, Moral I, Puy A, et al. Prevalence of post COVID-19 condition in primary care: a cross sectional study. Int J Environ Res Public Health. 2022;19(3):1836. doi:10.3390/ijerph19031836

Nabavi N. Long covid: how to define it and how to manage it. BMJ. 2020;370:m3489. doi:10.1136/bmj.m3489

World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus. October 6, 2021. Accessed September 22, 2022. https://apps.who.int/iris/handle/10665/345824

Chen C, Haupert SR, Zimmermann L, Shi X, Fritsche LG, Mukherjee B. Global prevalence of post-coronavirus disease 2019 (COVID-19) condition or long COVID: a meta-analysis and systematic review. J Infect Dis. 2022;226(9):1593-1607. doi:10.1093/infdis/jiac136

Michelen M, Manoharan L, Elkheir N, et al. Characterising long COVID: a living systematic review. BMJ Glob Health. 2021;6(9):e005427. doi:10.1136/bmjgh-2021-005427

Malik P, Patel K, Pinto C, et al. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-a systematic review and meta-analysis. J Med Virol. 2022;94(1):253-262. doi:10.1002/jmv.27309

National Institute for Health and Care Excellence. NICE Guideline, No. 188: COVID-19 rapid guideline: managing the long-term effects of COVID-19. Published December 18, 2020. Updated November 11, 2021. Accessed September 22, 2022. https://www.nice.org.uk/guidance/ng188

Pantasri T. Expanded roles of community pharmacists in COVID-19: a scoping literature review. J Am Pharm Assoc (2003). 2022;62(3):649-657. doi:10.1016/j.japh.2021.12.013

Ahjel SW, Al-Jumaili AA. The Pharmacist’s missing role in the COVID-19 pandemic. Innov Pharm. 2020;11(2):10.24926/iip.v11i2.3249. doi:10.24926/iip.v11i2.3249

Elbeddini A, Wen CX, Tayefehchamani Y, To A. Mental health issues impacting pharmacists during COVID-19. J Pharm Policy Pract. 2020;13:46. doi:10.1186/s40545-020-00252-0

Daniel WW, Cross CL. Biostatistics: A Foundation for Analysis in the Health Sciences. 11th ed. John Wiley & Sons; 2018.

Wangchalabovorn M, Weerametachai S, Leesri T. Prevalence of post COVID-19 conditions in SARS-CoV-2 infected patients at 3-month telephone follow-up. Regional Health Promotion Center 9 Journal. 2022;16(1):265-284.

Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601-615. doi:10.1038/s41591-021-01283-z

Cui X, Wang P, Wei Z. Emergency use of COVID-19 vaccines recommended by the World Health Organization (WHO) as of June 2021. Drug Discov Ther. 2021;15(4):222-224. doi: 10.5582/ddt.2021.01064

Taquet M, Dercon Q, Luciano S, Geddes JR, Husain M, Harrison PJ. Incidence, co-occurrence, and evolution of long-COVID features: a 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Med. 2021;18(9):e1003773. doi:10.1371/journal.pmed.1003773

Herman B, Wong MC, Viwattanakulvanid P. Vaccination status, favipiravir, and micronutrient supplementation roles in post-COVID symptoms: a longitudinal study. PLoS One. 2022;17(7):e0271385. doi:10.1371/journal.pone.0271385

Fernández-de-Las-Peñas C, Ortega-Santiago R, Fuensalida-Novo S, Martín-Guerrero JD, Pellicer-Valero OJ, Torres-Macho J. Differences in long-COVID symptoms between vaccinated and non-vaccinated (BNT162b2 Vaccine) hospitalized COVID-19 survivors infected with the delta variant. Vaccines (Basel). 2022;10(9):1481. doi:10.3390/vaccines10091481

Maglietta G, Diodati F, Puntoni M, et al. Prognostic factors for post-COVID-19 syndrome: a systematic review and meta-analysis. J Clin Med. 2022;11(6):1541. doi:10.3390/jcm11061541

Fernández-de-Las-Peñas C, Martín-Guerrero JD, Pellicer-Valero ÓJ, et al. Female sex is a risk factor associated with long-term post-COVID related-symptoms but not with COVID-19 symptoms: the long-COVID-EXP-CM multicenter study. J Clin Med. 2022;11(2):413. doi:10.3390/jcm11020413

Subramanian A, Nirantharakumar K, Hughes S, et al. Symptoms and risk factors for long COVID in non-hospitalized adults. Nat Med. 2022;28(8):1706-1714. doi:10.1038/s41591-022-01909-w

Koss J, Bohnet-Joschko S. Social media mining of long-COVID self-medication reported by Reddit users: feasibility study to support drug repurposing. JMIR Form Res. 2022;6(10):e39582. doi:10.2196/39582

Downloads

Published

2023-03-27

How to Cite

1.
Natanant S, Suriyong P. Incidence and Risk Factors of Post COVID-19 Condition: A Cross-sectional Study. Rama Med J [Internet]. 2023 Mar. 27 [cited 2024 Dec. 22];46(1):32-46. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/260117

Issue

Section

Original Articles