Age-related Hearing Loss and Aldosterone Treatment
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Abstract
Hearing loss is a common cause of disability in the global population. The prevalence of hearing loss is estimated to dramatically increase in the next decades with an increase in the number of older people. The fact that hearing loss correlates with aging suggests that age-related hearing loss (presbycusis) will be a critical issue and hearing care will be required. Untreated hearing loss has negative effects at multiple levels, such as hearing loss affecting the quality of life of hearing-impaired individuals, deteriorating family relationships, and interfering with economic growth. Unfortunately, treatments for hearing loss are limited to the use of hearing devices. Studies have shown that the number of hearing aid users is approximately 20% of all hearing-impaired individuals. Therefore, having alternative treatments is critical to reduce the number of people with hearing loss and to prevent a dramatic increase in the number of hearing-impaired individuals. In the future, a potential medication may be aldosterone (ALD). Studies have reported positive effects of ALD treatments on hearing loss in aged mice. ALD treatment in aged mice shows an improvement in hearing sensitivity and a healthier cochlear structure. Although higher ALD concentrations are associated with better hearing sensitivity and hearing in noise ability than lower concentrations, there is no clinical trial in ALD treatment in human has been reported.
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All articles are distributed by the Creative Commons Attribution (CC BY-NC-ND) license. Copyright © 2024 by the Authors. Licensee RMJ, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
References
Plomp R, Mimpen AM. Speech-reception threshold for sentences as a function of age and noise level. J Acoust Soc Am. 1979;66(5):1333-1342. doi:10.1121/1.383554
Stevens G, Flaxman S, Brunskill E, et al. Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countries. Eur J Public Health. 2013;23(1):146-152. doi:10.1093/eurpub/ckr176
Prasansuk S. Incidence/prevalence of sensorineural hearing impairment in Thailand and Southeast Asia. Audiology. 2000;39(4):207-211.
Weinberger MB. Population Aging: A Global Overview. In: Robinson M, ed. Global Health and Global Aging. Jossey-Bass San Francisco; 2007:15-30.
Lin FR, Ferrucci L. Hearing loss and falls among older adults in the United States. Arch Intern Med. 2012;172(4):369-371. doi:10.1001/archinternmed.2011.728
Lin FR, Yaffe K, Xia J, et al. Hearing loss and cognitive decline in older adults. JAMA Intern Med. 2013;173(4):293-299. doi:10.1001/jamainternmed.2013.1868.
Kamil RJ, Lin FR. The effects of hearing impairment in older adults on communication partners: a systematic review. J Am Acad Audiol. 2015;26(2):155-182. doi:10.3766/jaaa.26.2.6
Lazzarotto S, Baumstarck K, Loundou A, et al. Age-related hearing loss in individuals and their caregivers: effects of coping on the quality of life among the dyads. Patient Prefer Adherence. 2016;10:2279-2287. doi:10.2147/PPA.S112750
World Health Organization. Global costs of unaddressed hearing loss and cost-effectiveness of interventions: a WHO report, 2017. World Health Organization; 2017. Accessed December 7, 2022. https://apps.who.int/iris/handle/10665/254659
Strawbridge WJ, Wallhagen MI, Shema SJ, Kaplan GA. Negative consequences of hearing impairment in old age: a longitudinal analysis. Gerontologist. 2000;40(3):320-326. doi:10.1093/geront/40.3.320
Reed NS, Altan A, Deal JA, et al. Trends in health care costs and utilization associated with untreated hearing loss over 10 years. JAMA Otolaryngol Head Neck Surg. 2019;145(1):27-34. doi:10.1001/jamaoto.2018.2875
Heman-Ackah SE, Juhn SK, Huang TC, Wiedmann TS. A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice. Otolaryngol Head Neck Surg. 2010;143(3):429-434. doi:10.1016/j.otohns.2010.04.266
Halonen J, Hinton AS, Frisina RD, Ding B, Zhu X, Walton JP. Long-term treatment with aldosterone slows the progression of age-related hearing loss. Hear Res. 2016;336:63-71. doi:10.1016/j.heares.2016.05.001
Frisina RD, Frisina DR. Physiological and neurobiological bases of age-related hearing loss: biotherapeutic implications. Am J Audiol. 2013;22(2):299-302. doi:10.1044/1059-0889(2013/13-0003)
Tadros SF, Frisina ST, Mapes F, Frisina DR, Frisina RD. Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis. Hear Res. 2005;209(1-2):10-18. doi:10.1016/j.heares.2005.05.009
Pleis JR, Ward BW, Lucas JW. Summary health statistics for U.S. adults: national health interview survey, 2009. Vital Health Stat 10. 2010;(249):1-207.
Schacht J; Popper AN, Fay RR. Auditory Trauma, Protection, and Repair. Springer New York; 2008.
Pauler M, Schuknecht HF, Thornton AR. Correlative studies of cochlear neuronal loss with speech discrimination and pure-tone thresholds. Arch Otorhinolaryngol. 1986;243(3):200-206. doi:10.1007/BF00470622
Bernstein JG, Mehraei G, Shamma S, Gallun FJ, Theodoroff SM, Leek MR. Spectrotemporal modulation sensitivity as a predictor of speech intelligibility for hearing-impaired listeners. J Am Acad Audiol. 2013;24(04):293-306. doi:10.3766/jaaa.24.4.5
Ozmeral EJ, Eddins AC, Eddins DA. How do age and hearing loss impact spectral envelope perception? J Speech Lang Hear Res. 2018;61(9):2376-2385. doi:10.1044/2018_JSLHR-H-18-0056
Schneider BA, Pichora-Fuller MK. Age-related changes in temporal processing: implications for speech perception. Semin Hear. 2001;22(3):227-240. doi:10.1055/s-2001-15628
Eggermont JJ. Auditory brainstem response. Handb Clin Neurol. 2019;160:451-464. doi:10.1016/B978-0-444-64032-1.00030-8
Jerger J, Hall J. Effects of age and sex on auditory brainstem response. Arch Otolaryngol. 1980;106(7):387-391. doi:10.1001/archotol.1980.00790310011003
Chien W, Lin FR. Prevalence of hearing aid use among older adults in the United States. Arch Intern Med. 2012;172(3):292-293. doi:10.1001/archinternmed.2011.1408
Pimenta E, Gordon RD, Stowasser M. Salt, aldosterone and hypertension. J Hum Hypertens. 2013;27(1):1-6. doi:10.1038/jhh.2012.27
Bortner CD, Gómez-Angelats M, Cidlowski JA. Plasma membrane depolarization without repolarization is an early molecular event in anti-Fas-induced apoptosis. J Biol Chem. 2001;276(6):4304-4314. doi:10.1074/jbc.M005171200.
Trune DR, Kempton JB, Kessi M. Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000;110(11):1902-1906. doi:10.1097/00005537-200011000-00025
Crane MG, Harris JJ. Effect of aging on renin activity and aldosterone excretion. J Lab Clin Med. 1976;87(6):947-959.
Hegstad R, Brown RD, Jiang NS, et al. Aging and aldosterone. Am J Med. 1983;74(3):442-448. doi:10.1016/0002-9343(83)90971-3
Frisina RD, Ding B, Zhu X, Walton JP. Age-related hearing loss: prevention of threshold declines, cell loss and apoptosis in spiral ganglion neurons. Aging (Albany NY). 2016;8(9):2081-2099. doi:10.18632/aging.101045