Phytochemicals and Their Roles in Anti-aging

Authors

  • Bundit Promraksa Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • Jureerat Daduang Department of Clinical Chemistry/ Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
  • Tueanjit Khampitak Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • Wirapong Kantamala Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
  • Pranithi Hongsprabhas Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • Patcharee Boonsiri Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Keywords:

Aging, Anti-aging, Phytochemicals

Abstract

There is an increasing the number of elderly in Thailand and all over the world. Free radicals are the major cause of aging because they can destroy cells. This leads to pathology of human including obesity, cancer, diabeted mellitus, cardiovascular and immune diseases. The other causes of aging are food and pollution. Fruits and vegetables contain phytochemicals which have antioxidant activity. Many studies reported that phytochemicals play role in slow down the process of cell death and promoting autophagy both in vitro and in vivo. Therefore, research-based knowledge about phytochemicals has benefit in medicine as anti-aging agents.

References

Tosato M, Zamboni V, Ferrini A, Cesari M. The aging process and potential interventions to extend life expectancy. Clin Interv Aging. 2007;2(3):401-12.

Giacomoni PU. Ageing, science and the cosmetics industry. The micro-inflammatory model serves as a basis for developing effective anti-ageing products for the skin. EMBO Rep. 2005;6:S45-8.

Population of Thailand [database on the Internet]. 2014 [cited 2014 Jul 6].

Salvi SM, Akhtar S, Currie Z. Ageing changes in the eye. Postgrad Med J. 2006;82(971):581-7.

Wigham CG, Hodson SA. Physiological changes in the cornea of the ageing eye. Eye (Lond). 1987;1( Pt 2):190-6.

Boss GR, Seegmiller JE. Age-related physiological changes and their clinical significance. West J Med. 1981;135(6):434-40.

Kohn RR. Aging and cell division. Science. 1975;188:203-4.

Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961;25:585-621.

Orgel LE. The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc Natl Acad Sci USA. 1963;49:517-21.

Kavathia N, Jain A, Walston J, Beamer BA, Fedarko NS. Serum markers of apoptosis decrease with age and cancer stage. Aging (Albany NY). 2009;1(7):652-63.

Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11(3):298-300.

Cao Z, Li Y. Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur J Pharmacol. 2004; 489:39-48.

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG, Krakoff J. Higher energy expenditure in humans predicts natural mortality. J Clin Endocrinol Metab. 2011;96(6):E972-6. doi:10.1210/jc.2010-2944.

Michael R, Bron AJ. The ageing lens and cataract: a model of normal and pathological ageing. Philos Trans R Soc Lond B Biol Sci. 2011;366(1568):1278-92. doi:10.1098/rstb.2010.0300.

Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev. 2009;2(2):63-7.

Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol. 2006;126(12):2565-75.

Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D. Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Int J Mol Med. 2006;18(4):657-64.

Khansari N, Shakiba Y, Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009;3(1):73-80.

Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007;2(2):219-36.

Kohn RR. Effect of antioxidants on life-span of C57BL mice. J Gerontol. 1971;26(3):378-80.

González-Castejón M, Rodriguez-Casado A. Dietary phytochemicals and their potential effects on obesity: a review. Pharmacol Res. 2011;64(5):438-55. doi:10.1016/j.phrs.2011.07.004.

Dembinska-Kiec A, Mykkänen O, Kiec-Wilk B, Mykkänen H. Antioxidant phytochemicals against type 2 diabetes. Br J Nutr. 2008;99 E Suppl 1:ES109-17. doi:10.1017/S000711450896579X. Cytotoxic effects of Phytophenolics from Caesalpinia mimosoides Lamk on cervical carcinoma cell lines through an apoptotic pathway.

Palasap A, Limpaiboon T, Boonsiri P, et al. Asian Pac J Cancer Prev. 2014;15(1):449-54.

Rhone M, Basu A. Phytochemicals and age-related eye diseases. Nutr Rev. 2008;66(8):465-72. doi:10.1111/j.1753-4887.2008.00078.x.

Vasanthi HR, ShriShriMal N, Das DK. Phytochemicals from plants to combat cardiovascular disease. Curr Med Chem. 2012;19(14):2242-51.

Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651-62. doi:10.1056/NEJMra1205406.

Tresguerres IF, Tamimi F, Eimar H, et al. Melatonin dietary supplement as an anti-aging therapy for age-related bone loss. Rejuvenation Res. 2014;17(4):341-6. doi:10.1089/rej.2013.1542.

Olshansky SJ, Hayflick L, Carnes BA. Position statement on human aging. J Gerontol A Biol Sci Med Sci. 2002;57(8):B292-7.

Stipp D. A new path to longevity. Sci Am. 2012;306:32-9.

Rockenfeller P, Madeo F. Ageing and eating. Biochim Biophys Acta. 2010;1803(4):499-506. doi:10.1016/j.bbamcr.2010.01.001.

Mahlo SM, McGaw LJ, Eloff JN. Antifungal activity of leaf extracts from South African trees against plant pathogens. Crop Protection. 2010;29(12):1529-33.

Ghosh S, Liu B, Zhou Z. Resveratrol activates SIRT1 in a Lamin A-dependent manner. Cell Cycle. 2013;12(6):872-6. doi:10.4161/cc.24061.

Sin TK, Yu AP, Yung BY, et al. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart. J Physiol. 2014;592(12):2535-48. doi:10.1113/jphysiol.2014.271387.

Frescas D, Valenti L, Accili D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem. 2005;280(21):20589-95.

Vidavalur R, Otani H, Singal PK, Maulik N. Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. Exp Clin Cardiol. 2006;11(3):217-25.

Chattopadhyay P, Besra SE, Gomes A, et al. Anti-inflammatory activity of tea (Camellia sinensis) root extract. Life Sci. 2004;74(15):1839-49.

Salminen A, Kauppinen A, Kaarniranta K. Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process. Curr Opin Clin Nutr Metab Care. 2012;15(1):23-8. doi:10.1097/MCO.0b013e32834d3ae7.

Lima CF, Pereira-Wilson C, Rattan SI. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Mol Nutr Food Res. 2011;55(3):430-42. doi:10.1002/mnfr.201000221.

Hietakangas V, Cohen SM. Regulation of tissue growth through nutrient sensing. Annu Rev Genet. 2009;43:389-410. doi:10.1146/annurev-genet-102108-134815.

Polito F, Marini H, Bitto A, et al. Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats. Br J Pharmacol. 2012;165(4):994-1005. doi:10.1111/j.1476-5381.2011.01619.x.

Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys. 1989;274(2):532-8.

Porrini M, Riso P. Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J Nutr. 2000;130(2):189-92.

Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991;53:373-9.

Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000. Aging: The Biology of Senescence. https://www.ncbi.nlm.nih.gov/books/NBK10041/

Chen BT, Li WX, He RR, et al. Anti-inflammatory effects of a polyphenols-rich extract from tea (Camellia sinensis) flowers in acute and chronic mice models. Oxid Med Cell Longev. 2012;2012:537923. doi:10.1155/2012/537923.

OyetakinWhite P, Tribout H, Baron E. Protective mechanisms of green tea polyphenols in skin. Oxid Med Cell Longev. 2012;2012:560682. doi:10.1155/2012/560682.

Hsu S, Bollag WB, Lewis J, Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes. J Pharmacol Exp Ther. 2003;306(1):29-34.

Palermo V, Mattivi F, Silvestri R, La Regina G, Falcone C, Mazzoni C. Apple can act as anti-aging on yeast cells. Oxid Med Cell Longev. 2012;2012:491759.

Pandey R, Gupta S, Shukla V, Tandon S, Shukla V. Antiaging, antistress and ROS scavenging activity of crude extract of Ocimum sanctum (L.) in Caenorhabditis elegans (Maupas, 1900). Indian J Exp Biol. 2013;51(7):515-21.

Downloads

How to Cite

1.
Promraksa B, Daduang J, Khampitak T, Kantamala W, Hongsprabhas P, Boonsiri P. Phytochemicals and Their Roles in Anti-aging. Rama Med J [Internet]. 2015 Dec. 29 [cited 2024 Dec. 22];38(4):312-21. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/57538

Issue

Section

Review Articles