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Background: Idiopathic macular telangiectasia (IMT) associates with incompetence and ectasia of parafoveal retinal capillaries, causing significant loss of central vision. Many treatment modalities have been proposed to improve visual acuity such as laser, intravitreal injection of steroid, and anti-vascular endothelial growth factors. Nevertheless, the improvement in visual acuity was inconsistent.
Objective: To evaluate the effect of intravitreal ranibizumab on non-proliferative stage of idiopathic macular telangiectasia (IMT) in Thailand.
Methods: We conducted a retrospective, case series of 10 eyes (10 patients) in non-proliferative IMT treated with monthly intravitreal injection of 0.5 mg ranibizumab between July 2012 to March 2014 at Ramathibodi Hospital. Ophthalmic examination data, including best-corrected visual acuity (BCVA), fundus photograph, optical coherence tomography (OCT) and fluorescein angiogram (FA) were collected and interpreted by an experienced retinal specialist.
Results: Mean age was 52.9 ± 9.7 years. Median follow up time was 12.0 (8.0 - 17.0) months. Median BCVA improved from 0.35 (0.2 - 0.4) Logarithm of the Minimum Angle of Resolution (LogMAR) at baseline to 0.10 (0.0 - 0.3) LogMAR and 0.10 (0.0 - 0.4) LogMAR at third month and last visit, respectively. Mean central retinal thickness (CRT) was 374.3 ± 105.3 µm at baseline and decreased to 257.4 ± 84.3 µm and 242.4 ± 88.3 µm at third month and last visit, respectively. Mean changes in BCVA and CRT showed statistical significant different at third months and last visit compared to baseline. FA showed the reduction of leakage and staining at the end of treatment compared to baseline. No systemic and ocular adverse events were found.
Conclusions: Intravitreal ranibizumab might be the promising treatment for non-proliferative stage of IMT, in term of improving BCVA, decreasing CRT and FA leakage.
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