Next Generation of Cancer-treatment Targeting DNA Repair Pathway
Keywords:
Targeted therapy, DNA repair, PARP inhibitor, Cancer geneticsAbstract
Preservation of genomic information is important for species continuation. DNA repair mechanism is a major pathway responsible for correcting various type of DNA damage from single cellular organisms to complex multicellular organisms. Without DNA repair, mutation starts to accumulate in the genome and leads to genomic instability and cancer. In this article, we will review background of DNA damage repair, DNA repair deficiency in cancer cells and mechanism of targeting DNA repair pathway in cancer cells as a novel target for targeted cancer therapy.
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Copyright (c) 2015 By the authors. Licensee RMJ, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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