ฤทธิ์ต้านเซลล์มะเร็งของสารสกัดจากพืชวงค์ Guttiferae และ Schisandraceae

Abstract

To screen the in vitro antitumor activity of extracts from the selected Guttiferae and Schisandraceae plants. Materials and Methods: Twenty-two methanol and chloroform extracts from Guttiferae and Schisandraceaefamilies collected from the northern region of Thailand were tested for antitumor activity on HeLa (cervical carcinoma) KB (epidermoid carcinoma) and B16F10 (melanoma) human tumor cell lines using the sulforhodamine B (SRB) binding assay. Results: All extracts showed an antitumor activity with a dose response relationship. Thechloroform extract of G. speciosa showed  the potent inhibitory effect with the 50% growth inhibition (GI50) valueof 4.0, 6.6 and 3.7 ug/mL from the leaves and 9.9, 15.7 and 8.1 μg/mL from the wood against HeLa  KB and B16F10 tumor cell lines respectively. Chloroform extracts of H. hookerianum and G. xanthochymus showed the inhibitory effect on cell growth with GI50 value less than 20.μg/mL. Conclusion: The information from this study can  support the use of these plants in Thai traditional medicine and the further development of these extracts to new pharmaceuticals.