ฤทธิ์ต้านเซลล์มะเร็งของสารสกัดจากพืชวงค์ Guttiferae และ Schisandraceae
Main Article Content
Abstract
To screen the in vitro antitumor activity of extracts from the selected Guttiferae and Schisandraceae plants. Materials and Methods: Twenty-two methanol and chloroform extracts from Guttiferae and Schisandraceaefamilies collected from the northern region of Thailand were tested for antitumor activity on HeLa (cervical carcinoma) KB (epidermoid carcinoma) and B16F10 (melanoma) human tumor cell lines using the sulforhodamine B (SRB) binding assay. Results: All extracts showed an antitumor activity with a dose response relationship. Thechloroform extract of G. speciosa showed the potent inhibitory effect with the 50% growth inhibition (GI50) valueof 4.0, 6.6 and 3.7 ug/mL from the leaves and 9.9, 15.7 and 8.1 μg/mL from the wood against HeLa KB and B16F10 tumor cell lines respectively. Chloroform extracts of H. hookerianum and G. xanthochymus showed the inhibitory effect on cell growth with GI50 value less than 20.μg/mL. Conclusion: The information from this study can support the use of these plants in Thai traditional medicine and the further development of these extracts to new pharmaceuticals.
Downloads
Download data is not yet available.
Article Details
How to Cite
1.
มโนสร้อย จ. ฤทธิ์ต้านเซลล์มะเร็งของสารสกัดจากพืชวงค์ Guttiferae และ Schisandraceae. RTA Med. J. [internet]. 2013 Sep. 19 [cited 2026 Feb. 6];59(2):71-8. available from: https://he02.tci-thaijo.org/index.php/rtamedj/article/view/11761
Section
นิพนธ์ต้นฉบับ (Original Article)
Articles in this journal are copyrighted by the Royal Thai Army Medical Department and published under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
may be read and used for academic purposes, such as teaching, research, or citation, with proper credit given to the author and the journal.
Use or modification of the articles is prohibited without permission.
Statements expressed in the articles are solely the opinions of the authors.
Authors are fully responsible for the content and accuracy of their articles.
Any other republication of the articles requires permission from the journal.
