Outcomes of Kidney Transplantation at Phramongkutklao Hospital: A 27-year Experience

Main Article Content

Naowanit Nata
หนึ่งฤทัย จิมีสิก
อำนาจ ชัยประเสริฐ

Abstract

Background: Kidney transplantation (KT) is the best renal replacement therapy for end-stage renal disease (ESRD) patient. A successful KT improves quality of life and reduces mortality in the recipient. Assessment of KT outcome provides an opportunity to improve quality of care and management of the center.


Objective: To determine patient survival and allograft survival of kidney transplant recipients at Phramongkutklao Hospital (PMKH).


Methods: Follow-up data of KT recipient between1987–2016 were collected. Age greater than 18 with first KT was enrolled. Graft loss was defined as the need for permanent dialysis, re-transplantation, or death with functioning graft.


Results: Two hundred and sixty-five kidney transplant recipients received KT at PMKH during the study period, 109 patients were eligible for analysis. Average age was 39.2±9.2 years, 67.0% was male.  Living donor KT (LDKT) and cadaveric donor KT (CDKT) were 65.1% and 34.9 %, respectively. Median time for post transplantation follow up was 9 years (range 3-27 years). Waiting time for CDKT was 4.6± 3.1 years. Overall patient survival rates were 99.2, 97.0, and 90.2% at 1, 5, and 10 years, respectively. Primary cause of death was sepsis. The 1-year, 5-year and 10-year, overall graft survival rates were 99.1, 95.0, and 83.1%, respectively. Longest allograft survival of LDKT and CDKT in our center were 27 and 18 years, respectively.


Conclusions: Outcomes of 27-year experience of kidney transplantation at PMKH were good and similar to other center’s benchmarks.

Article Details

Section
นิพนธ์ต้นฉบับ (Original Article)

References

1. Lenihan CR, Tan JC. In Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, editors: Disorders of Acid-Base Balance. Brenner & Rector’s The Kidney 11th ed, Philadelphia 2020. p. 2244-88.
2. Rayner HC, Imai E, Kher V. Approach to Renal Replacement Therapy: In Feehally J, Floege J, Tonelli M, Johnson RJ, editors. Comprehensive Clinical Nephrology 6th ed, Elsevier 2019. p.1036-49.
3. Vasant Sumethkul, Kriengsak Vareesangthip, Surazee Prommool, Prajej Ruangkanchanasetr, Adisorn Lumpaopong, Attapong Vongwiwatana, et al. 2012 Annual Report of Kidney Transplantation in Thailand. Thai Transplantation Society. p. 1-32.
4. Kearkiat Praditpornsilpa, Sookruetai Lekhyananda, Nalinee Premasathian, Pornchai Kingwatanakul, Adisorn Lumpaopong, Pongsathorn Gojaseni MD, et al. Prevalence Trend of Renal Replacement Therapy in Thailand: Impact of Health Economics Policy. J Med Assoc Thai. 2011; 94 (Suppl. 4): S1-S6.
5. Noppakun K, Ingsathit A, Pongskul C, Premasthian N, Avihingsanon Y, Lumpaopong A, et al. Subcommittee for Kidney Transplant Registry; Thai Transplantation Society. A 25-year experience of kidney transplantation in Thailand: report from the Thai Transplant Registry. Nephrology (Carlton). 2015 Mar;20(3):177-83.
6. Premasathian N, Vongwiwatana A, Taweemonkongsap T, Amornvesukit T, Limsrichamrern S, Jitpraphai S, et al. The 37-year kidney transplantation experience at Siriraj Hospital. Clinical transplants. 2010:141-8.
7. Buranachokpaisan W. Patient Survival Rate of Renal Transplantation and Renal Allograft Survival Rate in BuddhachinarajPhitsanulok Hospital. Buddhachinaraj Medical Journal Volume 25 January-April 2008.
8. Ingsathit A. ปัจจัยที่มีผลต่อการเกิดไตวายหลังการผ่าตัดปลูกถ่ายไตในผู้ป่วยโรคไตที่เข้ารับการผ่าตัดเปลี่ยนไตในโรงพยาบาลรามาธิบดี. A thesis submitted in partial fullment of the requirement for the degree Doctor of philosophy (Clinical epidemiology) Faculty of graduate studies Mahidol University 2004.
9. Matas AJ, Gillingham KJ, Humar A, Kandaswamy R, Sutherland D, Payne WD, et al . 2,202 Kidney Transplant Recipients with 10 Years of Graft Function: What Happens Next. Am J Transplant. 2008 Nov; 8(11): 2410–19.
10. Vathsala A, Chow KY. Renal transplantation in Singapore. Ann Acad Med Singapore. 2009 Apr;38(4):291-9.
11. Tasaki M, Saito K, Nakagawa Y, Ikeda M, Imai N, Ito Y, et al. 20-year analysis of kidney transplantation: a single center in Japan. Transplant Proc. 2014;46(2):437-41.
12. Hawkins BR, Chan P, Chan YT, Cheng IK, Cheung KO, Fenn J, et al. Highly successful long-term outcome of kidney transplantation in Chinese recipients: an enhancing race effect. Clin Transplant. 1997 Jun;11(3):178-84.
13. Toma H, Tanabe K, Tokumoto T, Shimizu T, Shimmura H. Time-dependent risk factors influencing the long-term outcome in living renal allografts: donor age is a crucial risk factor for long-term graft survival more than 5 years after transplantation. Transplantation. 2001 Sep 15;72(5):940-7.
14. Ojo AO, Hanson JA, Wolfe RA, Leichtman AB, Agodoa LY, Port FK. Long-term survival in renal transplant recipients with graft function. Kidney International 2014; 307–3.
15. Briggs JD. Cause of death after kidney transplant. Nephrol Dial Transplant. 2001;16:1545-9.
16. Legendre C, Canaud G, Martinez F. Factors influencing long-term outcome after kidney transplantation. Transplt Int. 2014;27(1):19–27.