Potassium Loss in Peritoneal Fluid and Peritoneal Equilibration Test in End Stage Renal Disease Patients
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Abstract
Background: Hypokalemia is a common problem in continuous ambulatory peritoneal dialysis (CAPD) patients. Potassium loss in peritoneal dialysate fluid is one of the main mechanisms for hypokalemia. The relationship between amount of potassium loss in peritoneal dialysate fluid and peritoneal membrane transporter has never been studied.
Objective: To evaluate the relationship between peritoneal potassium loss and peritoneal equilibration test (PET).
Methods: A cross-sectional study was conducted among CAPD patients treated at Phramongkutklao Hospital, Bangkok, Thailand, during April to August 2018. Patients were designed into four groups according to PET; high (H), high average (HA), low average (LA) and low (L). Kruskal Wallis test was used to determine the relationship between peritoneal potassium loss and type of peritoneal membrane according to PET.
Results: There were 54 CAPD patients during the study period, 34 patients were eligible for analysis. Of 34 eligible CAPD patients (H; 7, HA; 14, LA; 13, and L; 0), 15 (44.1%) patients had hypokalemia. H and HA groups experienced hypokalemia more frequently than LA group. Mean peritoneal potassium loss was 27.9+6.9 mEq/day. No difference was found between peritoneal potassium loss and types of peritoneal membrane; mean of peritoneal potassium loss were 25.6+5.6, 26.5+6.3, and 30.8+7.2 in H, HA, and LA groups, respectively (p=0.15). Fractional excretion of potassium (FE K) from peritoneal membrane were significantly higher in LA group (1.29+0.27%) and HA group (1.28+0.22%) than H group (1.04+0.11%), p=0.03.
Conclusion: Overall potassium loss in peritoneal fluid was 27.9±6.9 mEq/day. No difference was found between amount of potassium loss and type of peritoneal membrane, but trend to be higher in the average groups.
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References
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