A Randomized, Double-blind, Controlled Trial between Bacterial Cellulose Gauze (BC) and Petrolatum Gauze (PG) in the Healing of Epidermal Ablative Wounds from Carbon Dioxide Laser.

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Nattaporn Sampattavanich
Chitsachee Sichanugrist
Kobkul Aunhachoke


Background: Bacterial cellulose (BC) was used to dress various wounds. BC has also applied burn wounds and ulcers as skin repair treatments. The carbon dioxide (CO2) laser has been widely used to treat numerous skin lesions. However, the benefit of BC gauze as wound dressing after CO2 laser has yet to be defined.


Objectives: To evaluate the efficacy of BC gauze compared with petrolatum gauze in epidermal ablative wound healing from a CO2 laser.


Materials and methods: We included 26 patients affected by at least two seborrheic keratosis lesions in the same area (face or non-face). After being treated by CO2 laser, the wounds in each patient were randomized into BC and PG groups. The dressings were changed on days 2, 4, 7, and 10 post-laser. Wound healing was assessed by BWAT score and ImageJ application during each visit. Pain scores and patient satisfaction were also recorded by visual analogue scales (VAS).


Results: Twenty-six volunteers completed the study. Most lesions were on the non-face area. BWAT scores in both BC and PG groups were not different (PG vs BC day 2=24.04 vs 24.19; p=0.895, day 4=20.88 vs 21.96; p=0.305, day 7=16.5 vs 16.42; p=0.918, day 10=14.31 vs 14.92; p=0.178). From ImageJ analysis, without statistically significant differences, BC showed a tendency for a higher percentage of wound epithelialization than PG (PG vs BC day 2=20.5 vs 24.6; p=0.373, day 4=40.52 vs 45.32%; p=0.354, day 7=58.03 vs 61.35; p=0.369, day 10=67.79 vs 70.9; p=0.426). Pain scores were not different between groups, but satisfaction scores of BC were significantly higher than PG on days 7 and 10. No complications from BC had been found in this study.

Conclusions: BC showed comparable efficacy with conventional dressing in epidermal ablative wound healing and can be safely used for CO2 laser wounds.

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นิพนธ์ต้นฉบับ (Original Article)


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