The Effect of Progesterone for Prevention of Preterm Birth in Women with Singleton Pregnancy between 24 – 36 Weeks of Gestational Age

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Chaiyakit Udnan
Research Taksin


Introduction and Objective: The using progesterone between 24 – 36 weeks of gestation age (GA) for pregnant women with preterm birth criteria was the best way to prevent preterm birth. Present, the effect of progesterone to prevent preterm birth by comparing between the intramuscular group and vaginal group has not been studied in Thailand. This research has aims to study the effect of progesterone for prevention of preterm birth in women with singleton pregnancy between GA 24 – 36 weeks and study the effect of progesterone on the newborn. Methods: This research was quasi-experimental research. Population was single-pregnant women with preterm birth who received progesterone between GA 24 - 36 weeks by compare study between experimental group was 37 women who received the injection of 17 OHPC at 250 mg. (Intramuscular) and control group was women who received natural micronized progesterone at 200 mg. (Vaginal). Instrument was data record form. Data were analyzed using descriptive and inferential statistics, including Chi-square tests and Independent t-tests. The statistical significance was set at a level of less than 0.05. Results: The research found that cervical length while receiving progesterone was correlated with both progesterone (p=0.001). The effect of progesterone on delivery was found that vaginal group had higher GA mean at delivery than intramuscular group (p=0.020) by vaginal and intramuscular group had GA mean at 36.96 ± 1.97 weeks and 35.71 ± 1.87 weeks. The effect of progesterone on newborns was found that vaginal group had NICU stay lower intramuscular group (p=0.047) by vaginal group and intramuscular group had mean of NICU stay at 7.54 ± 1.04 days and 13.79 ± 1.81 days. Conclusions: However, this research demonstrated outcome of vaginal progesterone in GA at delivery and NICU stay. Therefore, obstetricians and gynecologists should give vaginal progesterone to pregnant women with preterm birth.

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นิพนธ์ต้นฉบับ (Original Article)


Wanitpongpan P, Russameecharoen K, Lertbunnaphong T, editor, Modern text book of obstetrics. Bangkok: Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2017.

World Health Organization. Preterm birth. [Internet]. [Cited 2022 Jul 17]. Available from:

Kaewsiri P, Hemadhulin S, Ansook P, Naosrisorn P. The empowerment of pregnant women to prevent the risk of preterm labor: nurse’s roles. Srinagarind Med J 2020;35(2):238-45.

Muhumed I, Kebira J, Mabalhin M. Preterm birth and associated factors among mothers who gave birth in Fafen Zone Public Hospitals, Somali Regional State, Eastern Ethiopia. Research & Reports in Neonatology 2021;11:23-33.

Wongpikul O, Rotchananukunphong S, Kamronrit A. Good quality antenatal care should be given before 12 weeks of GA. [Internet]. [Cited 2022 Jul 17]. Available from:

The Royal Thai College of Obstetricians and Gynaecologists. RTCOG Clinical Practice Guideline Management of Preterm Labor and Preterm Prelabor Rupture of Membranes. [Internet]. [Cited 2022 May 12]. Available from: tent/uploads/2022/05/OB -64-027.pdf.

Data Center, Somdejphrajaotaksinmaharaj Hospital. Hospital report in fiscal year 2020. Tak: Somdejphrajaotaksinmaharaj Hospital, 2021:36-48.

Morgan JA, Phillips AL, Wang Y. Effectiveness of vaginal progesterone for short cervix diagnosed between 24 and 28 weeks of gestation. American J of Obs & Gyn 2022;226(Supp):S326.

Rattanakanokchai S, Laopaiboon M, Sangkomkamhang U, Pattanittum P. Risk of progesterone for preventing preterm delivery on gestational diabetes mellitus: a systematic review and meta-analysis. Srinagarind Med J 2016;31(6):355-64.

Berghella V, Saccone G. Cervical assessment by ultrasound for preventing preterm delivery (Review). Internet]. [Cited 2022 May 31]. Available from:

Smith R. Parturition. N Engl J Med 2007;356:271-83.

Saccone G, Khalifeh A, Elimian A, Bahrami E, Chaman-Ara K, Bahrami M, Berghella V. Vaginal progesterone compared to intramuscular 17-alpha hydroxy progesterone caproate for prevention of recurrent spontaneous preterm birth in singleton gestations: a systematic review and meta-analysis of randomized controlled trials. Ultrasound Obs Gyn 2017;49(3):315-321.

Tantawy WH, Ghaleb MM, Elsayed MMA. Vaginal versus intramuscular progesterone for prevention of preterm labour in women with a twin pregnancy: a randomized controlled trial. QJM: An Inter J of Med 2020;113(Supp1):293-9.

Artkamon S. Effects of vaginal micronized progesterone for prevention of preterm birth in pregnant women at Nongbuadaeng District, Chaiyaphum Province. Regional Health Promotion Center 9 2022;16(2):612-22.