Correlation of Post COVID-19 fatigue condition and Vitamin D deficiency in Thai older people
Article Sidebar
Main Article Content
Abstract
Background Due to the COVID-19 pandemic, more than 600 million people have been infected worldwide. Patients who recover from COVID-19 may experience long-term symptoms in 10-20% of cases, with the most common symptom being fatigue, which can affect daily life, especially in the older people. Studies have shown that low vitamin D levels are associated with severe COVID-19 infection and that vitamin D can suppress inflammation and help repair organs after COVID-19 infection. However, no studies have yet investigated the relationship between fatigue after COVID-19 infection and vitamin D levels .
Objectives To study correlation of Post COVID-19 fatigue condition and Vitamin D deficiency in
Thai older people . Therefore, we investigated the vitamin D levels of Thai volunteers aged 60-75 years with COVID-19 infection, divided into two groups: those diagnosed with fatigue after COVID-19 infection and those without at Outpatient department and Primary care unit of Phramongkutklao Hospital. between January to December 2023.
Results Vitamin D levels were significantly lower in the group with fatigue after COVID-19 infection than in the control group (Mean 28.10 ng/mL and 41.30 ng/mL, p = 0.0001748, Mann-Whitney U test) . There was no correlation between vitamin D levels and VAS fatigue scores in the group with fatigue (R = -0.1, p = 0.520) . People with diabetes, coronary heart disease, and high blood lipids had no significant difference in vitamin D levels compared to those without these diseases (p-value = 0.087, 0.584 and 0.136).
Conclusion This study suggests that low vitamin D levels may be a risk factor for fatigue after COVID-19 infection. Vitamin D supplementation may be an option to prevent or treat this condition, but further research is needed to confirm this relationship and test the effectiveness of vitamin D in treating fatigue after COVID-19 infection.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
World Health Organization. Naming the coronavirus disease (COVID-19) and the virus that causes it [Internet]. 2020 [cited 2020 November 9]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it
World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020 [internet]. 2020 [cited 2020 November 9]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020
Ritchie H, Mathieu E, Rodés-Guirao L, Appel C, Giattino C, Ortiz-Ospina E et al. Coronavirus Pandemic (COVID-19) [Internet]. Our World in Data. 2022 [cited 22 September 2022]. Available from: https://ourworldindata.org/covid-casess
Coronavirus disease (COVID-19): Post COVID-19 condition [Internet]. Who.int. 2022 [cited 22 September 2022]. Available from: https://www.who.int/news-room/questions-and-answers/item/coronavirus-disease-(covid-19)-post-covid-19-condition
โควิด-19 กรมการแพทย์ | หน้าหลัก (no date). Available at: https://covid19.dms.go.th/ (Accessed: November 18, 2022).
Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: When to test and how to treat [Internet]. Mayo Clinic proceedings. Mayo Foundation for Medical Education and Research; 2010 [cited 2022Nov5]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912737/#!po=0.480769
ข้อแนะนำเกี่ยวกับ ภาวะขาดวิตามินดี ในคนไทย, ข้อแนะนำเกี่ยวกับ ภาวะขาดวิตามินดี ในคนไทย – Thaiendocrine.org. Available at: http://www.thaiendocrine.org (Accessed: November 18, 2022).
Maltezou, H.C., Pavli, A. and Tsakris, A. (2021) “Post-covid syndrome: An Insight on its pathogenesis,” Vaccines, 9(5), p. 497.
Barrea L, Verde L, Grant W, Frias-Toral E, Sarno G, Vetrani C et al. Vitamin D: A Role Also in Long COVID-19?. Nutrients. 2022;14(8):1625.
โรจน์ยินดีเลิศ วีรนุช (no date) วิตามินดีกับสุขภาพ, Thai JPEN วารสารโภชนบำบัด. Available at: https://he02.tci-thaijo.org/index.php/ThaiJPEN/article/view/242743 (Accessed: November 18, 2022).
Martineau AR, Thummel KE, Wang Z, Jolliffe DA, Boucher BJ, Griffin SJ, et al. Differential effects of oral boluses of vitamin D2 vs vitamin D3 on vitamin D metabolism: A randomized controlled trial. The Journal of Clinical Endocrinology & Metabolism. 2019;104(12):5831–9.
Schematic illustration vitamin D synthesis pathway and signalling ... (no date). Available at: https://www.researchgate.net/figure/Schematic-illustration-vitamin-D-synthesis-pathway-and-signalling-mechanisms-relevant-to_fig1_336255216 (Accessed: November 18, 2022).
Roy, S. et al. (2014) Correction of low vitamin D improves fatigue: Effect of correction of low vitamin D in fatigue study (EVIDIF study), North American journal of medical sciences. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158648/?fbclid=IwAR0Gyf9jQQOqS7cr3_omesCkcEwI2wZjp3nVzGlwtgYtPH_lV8O8vdrHrpI (Accessed: 01 August 2023).
Siwamogsatham, O., Ongphiphadhanakul, B. and Tangpricha, V. (2014) Vitamin D deficiency in Thailand, Journal of clinical & translational endocrinology. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685050/ (Accessed: 01 August 2023).