Oral Sarcoidosis with Pulmonary Involvement: A Case Report with Literature Review
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Abstract
Sarcoidosis is an uncommon granulomatous disorder which rarely presents with intraoral lesions. We report a case of 26-year-old Thai male presented with solitary whitish to yellowish painless ulcerated and indurated plaque on the lower labial mucosa for 1 year. Histopathology revealed non-caseating granulomatous inflammation with multinucleated giant cells. Other granulomatous diseases were excluded prior to the diagnosis. Abnormal chest X-ray was detected by pre-employment screening. The patient was diagnosed as smear-negative pulmonary tuberculosis. Neither cutaneous lesion nor chest imaging had been changed after 5 months of standard anti-TB treatment. Tissue biopsy from right upper lung exhibited non-caseating granuloma with negative AFB, GMS stains. Culture for Mycobacterium tuberculosis and fungal cultures were also negative. The overall clinicopathology findings are compatible with oral sarcoidosis with pulmonary involvement.
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