Confounding Factors in Noninvasive Prenatal Testing under Common Benign Gynecologic Conditions
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Abstract
Noninvasive prenatal testing (NIPT) is increasing in use in obstetric practice worldwide, including in Thailand. While the efficacy of NIPT for prenatal aneuploidy detection is accepted, there are some pathologic conditions that can interfere with the NIPT result, such as maternal autoimmune disease or malignancies. Interestingly, some common benign gynecologic conditions, including uterine myoma, endometriosis, and mature ovarian cystic teratoma, have been reported to be confounding effects of maternal cell-free dexoxy ribonucleic acid (DNA) on the NIPT result.
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References
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