A Comparative Study of the Effectiveness and Safety of Pha Tam Ra Luang Drugs and Cafergot® on the Treatment of Migraine in Working Age Group

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Nitirat Meekai
Yongyudh Vajaradul
Supalak Fakkham
Wudtichai Wisuitiprot


A comparative study of the effectiveness and safety of Pha Tam Ra Luang medication and Cafergot®  for migraine was conducted in a group of working age people. This study was a quasi-experimental research study with a two-group pretest-posttest design. The sample included 70 participants aged 18-59 years who had been diagnosed by conventional medical doctors as migraineurs without aura and migraineurs with aura. The purposively selected sample was use to recruit migraine patients with moderate to severe pain at Wiang Nong Long Hospital in Lamphun Province. Thirty-five participants were assigned to the Pha Tam Ra Luang medication group and 35 were assigned to the Cafergot® group. Data were analyzed using descriptive statistics, including frequency, mean, percentage, standard deviation. Effectiveness and safety before and after the experiment were compared using a paired t-test. A comparison of effectiveness and safety between groups was tested using an independent t-test. The results showed that the Pha Tam Ra Luang medication had an analgesic effect, decreased pain levels and reduced headache duration at a statistical significance of .001. A comparison of effectiveness and safety between groups was statistically significant at .05.  In terms of safety, no adverse effects occurred after taking the medication. Liver and kidney function were within normal range. In conclusion, the study shows that Pha Tam Ra Luang medication can be an alternative for migraine patients.


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Meekai น, Vajaradul ย, Fakkham ศ, Wisuitiprot ว. A Comparative Study of the Effectiveness and Safety of Pha Tam Ra Luang Drugs and Cafergot® on the Treatment of Migraine in Working Age Group. NJPH (วารสาร พ.ส.) [Internet]. 2021 Dec. 30 [cited 2022 May 19];31(3):1-14. Available from: https://he02.tci-thaijo.org/index.php/tnaph/article/view/255632


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