A Comparative Study of the Effectiveness and Safety of Pha Tam Ra Luang Drugs and Cafergot® on the Treatment of Migraine in Working Age Group

Main Article Content

Nitirat Meekai
Yongyudh Vajaradul
Supalak Fakkham
Wudtichai Wisuitiprot

Abstract

A comparative study of the effectiveness and safety of Pha Tam Ra Luang medication and Cafergot®  for migraine was conducted in a group of working age people. This study was a quasi-experimental research study with a two-group pretest-posttest design. The sample included 70 participants aged 18-59 years who had been diagnosed by conventional medical doctors as migraineurs without aura and migraineurs with aura. The purposively selected sample was use to recruit migraine patients with moderate to severe pain at Wiang Nong Long Hospital in Lamphun Province. Thirty-five participants were assigned to the Pha Tam Ra Luang medication group and 35 were assigned to the Cafergot® group. Data were analyzed using descriptive statistics, including frequency, mean, percentage, standard deviation. Effectiveness and safety before and after the experiment were compared using a paired t-test. A comparison of effectiveness and safety between groups was tested using an independent t-test. The results showed that the Pha Tam Ra Luang medication had an analgesic effect, decreased pain levels and reduced headache duration at a statistical significance of .001. A comparison of effectiveness and safety between groups was statistically significant at .05.  In terms of safety, no adverse effects occurred after taking the medication. Liver and kidney function were within normal range. In conclusion, the study shows that Pha Tam Ra Luang medication can be an alternative for migraine patients.

Downloads

Download data is not yet available.

Article Details

How to Cite
1.
Meekai น, Vajaradul ย, Fakkham ศ, Wisuitiprot ว. A Comparative Study of the Effectiveness and Safety of Pha Tam Ra Luang Drugs and Cafergot® on the Treatment of Migraine in Working Age Group. NJPH (วารสาร พ.ส.) [Internet]. 2021 Dec. 30 [cited 2022 May 19];31(3):1-14. Available from: https://he02.tci-thaijo.org/index.php/tnaph/article/view/255632
Section
บทความวิจัย

References

1. World Health Organization. Headache disorders. World Health Organization. [Internet].2016 [cited 2020 April 20]. Available from: https://www.who.int/news-room/fact-sheets/detail/headache-disorders

2. Phanthumchinda K, Kamolratanakul P. Prevalence of primary headache in central region of Thailand: a cross sectional survey. Bulletin Neurological Society of Thailand 2000;16 Suppl 1:12-3.(in Thai).

3. American Headache Society. The American Headache Society position statement on integrating new migraine treatments into clinical practice. J Headache 2019;59:1-18.

4. Drug Information Service. Knowledgeable migraine headaches. Bumrungrad Hospital. [Internet].2020 [cited 2020 April 25]. Available from: https://www.bumrungrad.com/th/health-blog/february-2020/migraine-headache.(in Thai).

5. Supatat Reunawat. Migraine pain watch out for ergotamine antagonists. Faculty of Pharmacy Mahidol University.[Internet].2015 [cited 2020 April 25]. Available from:https://pharmacy.mahidol.ac.th/
th/knowledge/article/295/%E0%B8%9B%E0%B8%A7%E0%B8%94%E0%B9%84%E0%B8%A1%
E0%B9%80%E0%B8%81%E0%B8%A3%E0%B8%99-ergotamine/.(in Thai).

6. Thai traditional knowledge. Migraine treatment with herbal medicine. Kanchanaphisek Medical Center Mahidol University. [Internet].2015 [cited 2020 April 13]. Available from: https://www.gj.mahidol.ac.th/main/ttm/migrain/.(in Thai).

7. Phisanu Prasatwetch. Pha-Kam-Pree-Chuaw-Wa-Dann. In: Phisanu Prasatwetch, editors. Bangkok Thai Language Institute of Ministry of Education;1999.256-7.(in Thai).

8. Shahrajabian MH, Sun W, Cheng Qi. The power of natural Chinese medicine ginger and ginseng root in an organic life. Middle-East J of Scientific Research 2019;27(1):64-71.

9. Maghbooli M, Golipour F, Moghimi EA, Yousefi M. Comparison between the efficacy of ginger and Sumatriptan in the ablative treatment of the common migraine. Phytotherapy Research 2013;28(3):412-5.

10. Bahare Salehi, Zainul Amiruddin Zakaria, Rabin Gyawali, Salam A. Ibrahim, Jovana Rajkovic, Zabta Khan Shinwari, et al. Piper species: a comprehensive review on their phytochemistry biological activities and applications. Molecules 2019;24(7):65-6.

11. Jeyaraj A, Singh CR, Sundarraj S, Kannan S. In vitro regeneration of Cleome viscosa an important medicinal herb. Journal of Cell and Molecular Biology 2011;9(1):37-44.

12. Polit DF, Beck CT. Nursing research: generating and assessing evidence for nursing practice. 10th ed. Philadelphia: Wolters Kluwer Health;2017.

13. Makron Limudomporn, Pakakrong Kwankhao, Buntam Kitniyom, Pawatsara Kampheratham, Napatchaya Kessara, Chalalai Chokdeesrijan, et al. Effectiveness of Thai massage integrated into standard treatment for patients with migraine with or without aura. Journal of Health Science Research 2018;12(2):78-87.(in Thai).

14. Polit DF, Beck CT. Nursing research: generating and assessing evidence for nursing Practice. 8th ed. Philadelphia: Lippincott Williams & Wilkins;2008.

15. Butler PV. Linear analogue self-assessment and procrustean measurement: a critical review of visual analogue scaling in pain assessment. J Clin Psychol Med Setting 1997;4(1):111-29.

16. Peterlin BL, Gupta S, Ward TN, MacGregor A. Sex matters: evaluating sex and gender in migraine and headache research. Journal of Head and Face Pain 2011;51(6):839–42.

17. Muangthong P, Kongsaktrakul D, Visudtibhan A, Chansatitporn N,. Predicting factors of quality of life among secondary and high school students with migraine symptoms. Journal of Nursing M, and Health Care 2018;36(1):145-53.(in Thai).

18. Maghbooli M, Golipour F, Moghimi AM, Esfandabadi, Yousefi M,. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. J Phytotherapy Research 2014; 28:412-15.


19. Sohrabi R, Pazgoohan N, Seresht HR, Amin B,. Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. Iranian Journal of Basic Medical Sciences 2017;20(6):708-14.

20. Karen E. Wells, David L. Steed, Albert B. Zajko, Marshall W. Recognition and treatment insufficiency from Cafergot of arterial. Journal of Vascular Surgery 1986;4(1):8-15.

21. Kritsamphan C, Phichit N,. Ergotamine tartrate in treatment Acute Migraine Headache. School of Pharmaceutical Sciences [Internet].2020 [cited 2020 April 25]. Available from: http://www.pharmacy.up.ac.th/PHAR1/Newsletter/Medical%20personnel/may-june.59/1.(in Thai).