Wound Complications after Surgical Treatment of Extremity Soft Tissue Sarcoma in Sakonnakhon Hospital
Keywords:
Soft tissue sarcoma, Postoperative wound complicationAbstract
Soft tissue sarcomas (STS) occur most common in the extremities. The standard treatment is surgery combined with radiation and chemotherapy. There are many postoperative wound complications (WC). The objectives of this study were to assess the incidence and the factors associated with WC in the patient with extremity soft tissue sarcomas. Between July 2018 and June 2021, 23 patients with STS of extremities were retrospectively identified from our database. Factors was reviewed comprising of patient age, tumor size, tumor grade, tumor location, tumor depth, type of surgery (limb sparing surgery or amputation), chemotherapy and/or postoperative radiation that associated with WC. Logistic regression and Fisher probability test were employed to analyzed univariate and multivariate association between the factors and the outcome.
Results: The cumulative incidence of overall WC was 39.1%. The mean age of the complication and non-complication group were 55.6 (SD 13.7) and 42.3 (SD 18.0) years old, respectively. The postoperative wound complications and hematoma collection. Patients with WC were older (50.0% vs 35.5%), had higher grade tumor (55.6% vs 28.6%), tumor size > 8 cm (50.0% vs 22.0%), received postoperative radiation (57.2% vs 11.1%). The postoperative radiation was associated with overall wound complications (crude OR 10.667, p=0.047) by univariate analysis, but no statistically significant in multivariate analysis. Deep-seated tumor (p=0.037) and high-grade tumor (p=0.004) showed association with wound infection by univariate analysis. Tumor location, tumor size, tumor location, patient age, type of surgery and chemotherapy had no statistically significant associated with WC in this study.
Conclusions: Postoperative radiation was associated with overall WC by univariate analysis, however this factor was not associated by multivariate analysis. High-grade tumor and deep-seated tumor were associated with postoperative wound infection by univariate analysis.
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