Effects of Combined Administration of Intravenous and Intra-articular Tranexamic Acid Versus Intravenous Alone to Reduce Blood Loss After Total Knee Arthroplasty
Keywords:
total knee arthroplasty, blood loss, tranexamic acidAbstract
This retrospective study aimed to compare between of combined administration of intravenous and intra-articular tranexamic acid versus intravenous only to reduce blood loss after total knee arthroplasty (TKA), at Wanonniwat hospital. The samples were patients who had performed total knee arthroplasty at Wanonniwat hospital from January 1st, 2015 – December 31st, 2022 and classified to 2 groups included the experiment group of using combined intravenous and intra-articular administration and the control group of using intravenous tranexamic acid only, simple random sampling for 25 samples each group. The research instrument was case record form, the data was collected on the month of September, 2023 and was analyzed by frequency, percentage, mean, standard deviation, compared calculated blood loss between groups used statistic of Independent T-test.
The result show; the general characteristics of the experimental group and control group all were female, mean age 65.32±7.39 and 65.56±6.91 years old average BMI 26.12±4.69 and 25.07±4.20 kg/m2, had underlying disease 72.00% and 60.00%, ASA classification II 72.00% and 60.00%, average time of surgery 120.0±5.77 minutes and 122.40±12.34 minutes, average tourniquet time 120.0±5.77 minutes and 123.60±13.50 minutes, average preoperative hematocrit 35.96±4.15% and 35.52±3.23%, respectively. The mean calculated blood loss in experiment group after surgery 24 hours and 48 hours ( =215.76±146.88 ml, and =217.27±145.81 ml) was lower than control group ( =422.53±222.09 ml, and =422.53±222.09 ml) with significantly statistics difference (p<0.001, and p<0.001, respectively ). And found that the experiment group had received blood transfusion 8.00% compared to control group 44.00%, and had no complication in both groups.
This research concluded that combined administration of intravenous and intra-articular Tranexamic acid reduced blood loss in total knee arthroplasty more than intravenous only.
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