Incidence and Factors Associated with Hypersensitivity Reactions in Breast Cancer Patients Receiving Taxanes via Peripheral Intravenous Administration in the Mahavajiravudh 6A Ward (Day Care Chemotherapy) at Vajira Hospital
Article Sidebar
Main Article Content
Abstract
Hypersensitivity reactions to taxane-based chemotherapy are clinically significant
adverse drug reactions that may affect treatment continuity. This prospective
descriptive study aimed to investigate the incidence and factors associated with
hypersensitivity reactions in breast cancer patients receiving taxane-based
chemotherapy via peripheral intravenous administration between April and
October 2025. The sample consisted of 275 patients selected by simple random
sampling. Research instruments included a demographic questionnaire,
a treatment history questionnaire, a stress assessment scale, and an anxiety
assessment scale. Data were analyzed using descriptive statistics and logistic regression analysis.
The results showed that the incidence of hypersensitivity reactions among breast
cancer patients receiving Taxane-based chemotherapy via peripheral intravenous
administration was 49.82%. Factors significantly associated with hypersensitivity
reactions at the .05 level included age ≥ 60 years (Adjusted OR = 6.73, 95%
CI = 1.15–39.53), body mass index of 30.0–34.9 kg/m² (Adjusted OR = 3.96, 95%
CI = 1.16–13.53) and ≥ 35.0 kg/m² (Adjusted OR = 4.53, 95% CI = 1.07–19.09),
history of drug allergy (Adjusted OR = 2.79, 95% CI = 1.15–6.76), high stress
level (Adjusted OR = 4.22, 95% CI = 1.21–14.68), very high stress level (Adjusted
OR = 3.42, 95% CI = 1.08–10.82), and high anxiety level (Adjusted OR = 3.03,
95% CI = 1.22–7.51). These findings may be used as a guideline for risk
assessment and monitoring planning to enhance the safety and effectiveness of
chemotherapy administration.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The content and information presented in articles published in the Vajira Nursing Journal reflect the views and responsibilities of the authors exclusively. The editorial board does not necessarily agree with or share any responsibility for these views.
All articles, information, content, images, etc., published in the Vajira Nursing Journal are the copyright of the journal. Any individual or organization wishing to reproduce, disseminate, or use any part or entirety of the published material must obtain prior written permission from the Vajira Nursing Journal.
References
Giaquinto AN, Sung H, Newman LA, Freedman RA, Smith RA, Star J, et al. Breast cancer statistics 2024. CA Cancer J Clin. 2024;74(6):477-95. doi:10.3322/ caac.21863
National Cancer Institute, Department of Medical Services, Ministry of Public Health. Hospital-based cancer registry 2022. Bangkok: National Cancer Institute; 2023.
National Cancer Institute, Department of Medical Services, Ministry of Public Health. Standard guidelines for chemotherapy administration and post-chemotherapy patient care. Bangkok: New Thamda Printing; 2020.
Tsao LR, Young FD, Otani IM, Castells MC. Hypersensitivity reactions to platinum agents and taxanes. Clinic Rev Allergy Immunol. 2022;62(3):432-48. doi: 10. 1007/s12016-021-08877-y
Loisaratakul N, Udomphon N, Phanna P. Incidence and factors associated with hypersensitivity reactions to paclitaxel in patients with cancer. Thai J Cancer. 2019;39(4):143–52.
Otani IM, Lax T, Long AA, Slawski BR, Camargo CA, Banerji A. Utility of risk stratification for paclitaxel hypersensitivity reactions. J Allergy Clin Immunol Pract. 2018;6(4):1266-73. doi: 10.1016/j.jaip. 2017.08.025
Galateanu B, Puscasu AI, Tircol SA, Tanase BC, Hudita A, Negrei C, et al. Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions. Int J Mol Sci. 2023;24(4):3886. doi: 10. 3390/ijms24043886
Oppegaard K, Harris CS, Shin J, Paul SM, Cooper BA, Levine JD, et al. Anxiety profiles are associated with stress, resilience and symptom severity in outpatients receiving chemotherapy. Support Care Cancer. 2021;29(12):7825-36. doi: 10.1007/s00520-021-06372-w
Fungfuang S. Nursing roles in the management of hypersensitivity reactions and adverse reactions related to intravenous chemotherapy administration. Thai J Cancer. 2018;38(1):29–41.
Puanphai K, Suwannakrihas N, Tantiwut K. Factors associated with hypersensitivity reactions to paclitaxel in patients with lung cancer receiving chemotherapy at an outpatient chemotherapy unit of Maharaj Nakorn Chiang Mai Hospital. Nurs J CMU. 2022;49(1):238–50.
Sendo T, Sakai N, Itoh Y, Ikesue H, Kobayashi H, Hirakawa T, et al. Incidence and risk factors for paclitaxel hypersensitivity during ovarian cancer chemotherapy. Cancer Chemother Pharmacol. 2005; 56(1):91-6. doi:10.1007/s00280-004-0924-9
Park HJ, Ko M, Kim I-W, Oh JM. Personalized risk assessment for taxane-induced hypersensitivity reactions: a systematic review and meta-analysis. J Pers Med. 2025;15(1):2-22. doi: 10.3390/jpm1501 0002
Joseph PV, Nolden A, Kober KM, Paul SM, Cooper BA, Conley YP, et al. Fatigue, stress, and functional status are associated with taste changes in oncology patients receiving chemotherapy. J Pain Symptom Manage. 2021;62(2):373-82. doi: 10.1016/ j.jpainsymman.2020.11.029
Zhu H, Yang L, Yin H, Yuan X, Gu J, Yang Y. The influencing factors of psychosocial adaptation of cancer patients: a systematic review and meta-analysis. Health Serv Insights. 2024;17(4):1-14. doi: 10.1177/11786329241278814
Verhoeff-Jahja R, ter Kuile MM, Weijl NI, Oosterkamp R, Cloos M, Portielje JEA, et al. Symptoms of anxiety but not depression before start of taxane-based chemotherapy are associated with peripheral neuropathy: a multicenter study in women with breast cancer. Support Care Cancer. 2022;30(8):6947-53. doi:10.1007/s00520-022-07093-4
Daniel W. Biostatistics: A foundation for analysis in the health cciences. 9th ed. New York: John Wiley & Sons; 2003.
Bursac Z, Gauss CH, Williams DK, Hosmer DW. Purposeful selection of variables in logistic regression. Source Code Biol Med. 2008;3(1):17. doi: 10. 1186/1751-0473-3-17
Hair JF, Black WC, Babin BJ, Anderson RE. Multivariate data analysis. 6th ed. Upper Saddle River: Pearson Prentice Hall; 2006.
Hosmer D.W., Lemeshow S. Applied logistic regression. 2nd ed. New York: Wiley; 2000.
