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Medication non-compliant behavior of persons with schizophrenia leads to relapse and chronic illness. This study is a pre-posttest quasi-experimental study aiming to examine the effect of motivational interviewing programs on medication compliance behaviors of persons with schizophrenia in hospitals. The samples included persons with schizophrenia hospitalized in Prasrimahabhodi Psychiatric Hospital. They were selected by a simple random sampling by drawing a lottery by specifying even numbers as the experimental group and odd numbers as the control group, assigned into the experimental (n = 12) and the control (n=12) group. Research instruments are a personal information form and medication compliance behavior measurement. The experimental tool is the motivational interview program that developed the motivational interview concept of Miller and Rollnick. Descriptive statistics, Independent t-test, and dependent t-test were employed to analyze the data. The results revealed that after the program, the medication-compliant behaviors of the experimental group were significantly higher than those in the control group. The medication-compliant behaviors of the experimental group after the program were statistically significantly higher than before the program at the statistical level of 0.05. Therefore, it should promote the Motivational Interviewing Program on Medication Compliance Behaviors of persons with Schizophrenia in hospital to prevent the recurrence of psychotic symptoms in schizophrenia patients. In addition, the researchers should apply this program to other groups of psychiatric patients for medication compliance.
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