Treatment Outcome of Acute Kidney Injury in Patients with COVID-19 Infection
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Abstract
In the condition that acute kidney injury (AKI) is caused by COVID-19 infection, if patients are treated promptly, there is a chance that the kidney will recover back to normal. This study aimed to determine the treatment outcomes of patients with AKI from COVID-19 infection and risk factors for mortality. The study design was a retrospective cohort study. All data were collected from medical records of patients with COVID-19 infected and diagnosed with AKI from January 1, 2020 to May 31, 2022. The statistic used for data analysis was multiple logistic regressions. The results revealed that 96 patients were COVID-19 infection and diagnosed with AKI and all of them received antiviral therapy treatment, 60 recovered, 36 died, 42 developed severe pneumonia requiring ventilators, 11 required renal replacement therapy, and 5 progressed to CKD. Risk factors of mortality were female (AOR = 2.02; 95%CI: 1.74-5.45), aged 61-70 years (AOR = 3.78; 95%CI: 1.83-7.20), aged >70 years (AOR = 2.17; 95%CI: 1.66-7.10), AKI stage 2 (AOR = 2.52; 95%CI: 1.12-6.32), AKI stage 3 (AOR = 2.96; 95%CI: 1.37-9.62), ICU admission (AOR = 2.98; 95%CI: 1.79-11.25), mechanical ventilators used (AOR = 3.71; 95%CI: 1.33-10.34), and septic shock (AOR = 2.24; 95%CI: 1.67-7.44). In conclusion, 60 patients were cured and 5 patients progressed to CKD. The risk factors for mortality among COVID-19 patients with AKI development were AKI, gender, age, septic shock, severely ill patients admitted to intensive care units, and ventilator use.
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