Factors Related to Mortality among Patients with COVID-19 in the Intermediate Care Unit

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Orawan Bootthumpan
Wasana Lavin
Porntip Yooyadmak

Abstract

COVID-19 is an infectious disease that is spreading around the world. The symptoms were found to be asymptomatic, symptomatic, and severe; a severe symptom needs care in the ICU. In severe group, it had the highest mortality rate. This research aimed to study the association between SpO2 / FiO2 ratio (S/F ratio) and mortality in COVID-19 patients in the intermediate care unit. The 489 subjects were diagnosed as the COVID-19-infected. Data was designed as a retrospective and measured from 17 April to 30 September 2021. This research used the descriptive statistics and the Fisher’s exact test, and chi-square test to analyze the association between the S/F ratio and the mortality rate in COVID-19 patients. The results revealed that 15 persons were dead. The sample groups were > 75 years (p-value <0.001), Charlson comorbidity index (CCI) ≥4 points (p-value <0.001), hypertension (p-value = 0.045), S/F ratio <150 (p-value = 0.014), and chronic kidney disease (p-value = 0.030) were associated with mortality in COVID-19 patients. The results of this research were used as a guideline for applying the S/F ratio for emergency treatment in order to plan for nursing care and further care of patients.

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How to Cite
1.
Bootthumpan O, Lavin W, Yooyadmak P. Factors Related to Mortality among Patients with COVID-19 in the Intermediate Care Unit. Health Sci J Thai [Internet]. 2024 Jan. 24 [cited 2024 May 4];6(1):27-33. Available from: https://he02.tci-thaijo.org/index.php/HSJT/article/view/262064
Section
Original articles

References

Dechawongse S, Nyanaviro PW, Mahaviro PS. COVID-19: Change in the Thai language. Journal of Education MCU. 2020;8(2):827–36. (in Thai)

Choi KJ, Hong HL, Kim EJ. The association between mortality and the oxygen saturation and fraction of inhaled oxygen in patients requiring oxygen therapy due to COVID-19 associated pneumonia. Tuberc Respir Dis (Seoul) 2021; 84: 125-133

Castro MC, Gurzenda S, Macario EM, Franca GVA. Characteristics, outcomes and risk factors for mortality of 522167 patients hospitalized with COVID-19 in Brazil: a retrospective cohort study. BMJ Open. 2021; 11 (e049089):1-9.

Shimizu M, Hashimoto S. Peripheral oxygen saturation to inspiratory oxygen fraction ratio based identification of critically ill coronavirus disease patients for early therapeutic interventions. Journal of Anesthesia. 2021; 35: 827–836.

Lu X, Jiang L, Chen T, Wang Y, Zhang B, Hong Y, et al. Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19. Respiratory Research 2020; 21(194): 1-4.

Satici MO, Islam MM, Satici C, Uygun CN, Ademoglu E, Altunok I, et al. The role of a noninvasive index ‘Spo2/ Fio2’ in predicting mortality among patients with COVID-19 pneumonia. Am J Emerg Med 2022; 57: 54-9.

Shimizu M, Hashimoto S. Peripheral oxygen saturation to inspiratory oxygen fraction ratio based identification of critically ill coronavirus disease patients for early therapeutic interventions. J. Anesth. 2021; 35:827–36.

Fukuda Y, Tanaka A, Homma T, Kaneko K, Uno T, Fujiwara A, et al. Utility of SpO2/FiO2 ratio for acute hypoxemic respiratory failure with bilateral opacities in the ICU. PLoS ONE 2021; 16(1): e0245927:1-11.

Banchongcharoenlert S, Chumchuen P. Case Fetal Rate and Factors Associated with Deaths due to COVID-19 in Damnoen Saduak Hospital, Ratchaburi Province. RHQJ 2022; 2(1):25-37. (in Thai)

Pratipanawat P. Factors of Affecting fatality with COVID-19 patients in Kalasin Hospital. J Environ Educ. 2022; 7(1):64-71. (in Thai)

Singh AK, Gupta R, Misra A. Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers. Diabetes Metab. Syndr 2020; 14(4): 283-7.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395: 1054-62.

Wang L, Li X, Chen H, YanS, Li D, Li Y, et al. Coronavirus disease 19 infection does not result in acute kidney injury: An analysis of 116 hospitalized patients from Wuhan, China. Am J Nephrol 2020; 51: 343-48.

Carvalho VP, Pontes JPJ, Neto DR, Borges CER, Campos GRL, Ribeiro HLS, et al. Mortality and associated factors in patients with COVID-19: Cross-sectional study. Vaccines 2023; 11(71): 1-10.

Adams JY, Rogers AJ, Schuler A, Marelich GP, Fresco JM, Taylor SL, et al. Association between peripheral blood oxygen saturation (SpO2)/ Fraction of inspired oxygen (FiO2) ratio time at risk and hospital mortality in mechanically ventilated patients. Perm J 2020; 24(19.113): 1-7.

Lavin W, Yooyadmak P, Phenglai C. Risk of mortality among COVID-19 patients admitted to intermediate ICU: A study during the third wave of COVID-19 pandemic. Dis Control J 2023; 49(1): 711-21. (in Thai)

Manmana S, Iamsirithaworn S, Uttayamakul S. Coronavirus Disease-19 (COVID-19). Bamras J 2020; 14(2): 124-33. (in Thai)

Frederick KH, Petermann-Rocha F, Gray SR, Jani BD, Katikireddi SV, Niedzwiedz CL, et al. Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants. PLoS ONE. 2020; 15 (11): e0241824:1-15.

Srisompong J. Predictive factors associated with mortality outcomes of severe COVID-19 pneumonia in elderly patients, Suratthani Hospital, Thailand. Reg11med. 2023; 11(37):1-19. (in Thai)

Wang Z, Wang Z. Identification of risk factors for in-hospital death of COVID-19 pneumonia – lesions from the early outbreak. BMC Infect. Dis. 2021; 21(113): 1-13.