เปรียบเทียบความแตกต่างความเสี่ยงการเกิดเหตุการณ์ชนิดรุนแรงจากสาเหตุหัวใจ และหลอดเลือดในผู้ป่วยกลุ่มอาการกล้ามเนื้อหัวใจขาดเลือดเฉียบพลัน เพศหญิงและเพศชาย ในช่วง 1 ปีแรกหลังจำหน่ายออกจากโรงพยาบาล
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การศึกษามีวัตถุประสงค์เปรียบเทียบความเสี่ยงการเกิดเหตุการณ์ชนิดรุนแรงจากสาเหตุหัวใจและหลอดเลือด (Major adverse cardiovascular events [MACE]) ในผู้ป่วยกลุ่มอาการกล้ามเนื้อหัวใจขาดเลือดเฉียบพลัน จำแนกตามเพศ 1 ปีหลังจำหน่ายออกจากโรงพยาบาลโดยใช้เครื่องมือ Global Registry of Acute Coronary Events (GRACE) risk score ข้อมูลทุติยภูมิของกลุ่มตัวอย่าง 187 ราย ในโรงพยาบาลระดับทุติยภูมิแห่งหนึ่ง วิเคราะห์ความสัมพันธ์ต่อการเกิด MACE ใช้การทดสอบไคสแคว์/ฟิชเชอร์เอ็กแซกและสถิติถดถอยโลจิสติกทวิ ผลการศึกษา พบว่า เพศหญิงมีคะแนนความเสี่ยง GRACE risk score และระดับความเสี่ยงสูงมากกว่าเพศชาย (p-value = 0.001, 0.004 ตามลำดับ) และปัจจัยที่มีความสัมพันธ์ต่อการเสียชีวิตรวมเพศหญิงและชายมีนัยสำคัญทางสถิติ ได้แก่ อายุ ≥80 ปี (Adjusted OR = 5.38, 95%CI: 1.40-20.69) และเอนไซม์กล้ามเนื้อหัวใจสูงผิดปกติ (Adjusted OR = 5.04, 95%CI: 1.03-24.47) การจำแนกตามเพศ พบว่า ปัจจัยอายุ ≥80 ปีมีความสัมพันธ์ต่อการเสียชีวิตเฉพาะในเพศชายอย่างมีนัยสำคัญทางสถิติ (Adjusted OR = 8.56, 95%CI: 1.57-46.56) ผลการศึกษาชี้ว่าอายุเป็นปัจจัยที่สำคัญต่อการเกิด MACE โดยเฉพาะอย่างยิ่งผู้ป่วยที่มีอายุ ≥80 ปี ร่วมกับมีผลเอนไซม์กล้ามเนื้อหัวใจสูงผิดปกติ และ/หรือ มีประวัติเจ็บป่วยด้วยภาวะหัวใจล้มเหลว ควรได้รับการดูแลอย่างทันท่วงทีและต่อเนื่อง
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