Pain Reduction in Rigid Nasendoscopy between 1% Lidocaine with Oxymetazoline and 2% Lidocaine with Oxymetazoline: A Double-Blind Randomized Controlled Trial


  • Nattarangsi W, Intrarak T


Local anesthetics, Decongestant, Nasendoscopy, Pain


Background: Low-dose lidocaine mixed with oxymetazoline can reduce pain during rigid nasendoscopy. However, the optimal dose of lidocaine is controversial.

Objective: This study aimed to investigate the effect of 1% lidocaine mixed with oxymetazoline and 2% lidocaine mixed with oxymetazoline on reducing pain in patients undergoing rigid nasendoscopy.

Method: This double-blind randomized controlled trial was conducted on patients undergoing rigid nasendoscopy between June to July 2019 at the Department of Otolaryngology, Burapha University Hospital. Nasal cavities were randomized to receive pledgets soaked with 1% lidocaine mixed with oxymetazoline or 2% lidocaine mixed with oxymetazoline. The visual analogue scale (VAS) was used to evaluate the discomfort caused by medication and nasal pain caused by endoscopy. The data were analyzed using descriptive statistics and Wilcoxon signed-rank test.

Result: The findings showed that there were 36 patients (27 female, 9 male) with an average age of 43.14 years. The discomfort was not statistically different between the 1% lidocaine group and the 2% lidocaine group (0.92 ± 1.51 and 1.00 ± 1.24 respectively, p = 0.70). The nasal pain was not statistically different between two groups (4.22 ± 2.32 and 3.97 ± 2.06 for the 1% lidocaine group and the 2% lidocaine group respectively, p = 0.31). No adverse drug reaction was identified in the study.

Conclusion: Preparing the patients prior to rigid nasendoscopy with oxymetazoline mixed with either 1% lidocaine or 2% lidocaine could be reasonable.


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How to Cite

วิพรร ณัฐรังสี พ.บ., ธนวิทย์ อินทรารักษ์ พ.บ. Pain Reduction in Rigid Nasendoscopy between 1% Lidocaine with Oxymetazoline and 2% Lidocaine with Oxymetazoline: A Double-Blind Randomized Controlled Trial. j dept med ser [Internet]. 2020 Sep. 1 [cited 2022 Aug. 14];45(2):91-7. Available from:



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