A Retrospective Comparison of Thai patients with End-stage Renal Disease Who Chose to Decline or Receive Dialysis Therapy

Authors

  • Jukkapong Hengtrakulvenit, M.D
  • Kanokwan Prommachat, M.N.S
  • Suchanya Promnim, B.N.S.
  • Napaporn Boonyuen, M.N.S
  • Jidaporn Intapong, B.N.S.
  • Pattraporn Meesiri, B.N.S.
  • Vinai Leesmidt, M.D.
  • Kriang Tungsanga, M.D.

Keywords:

End-stage renal disease, Decline dialysis therapy

Abstract

Background : Chronic kidney disease is commonly observed in the rural area of Thailand. A part of patients with end-stage kidney disease declined to received dialysis care despite lack of medical contraindications.

Objectives : We compared the patients with end-stage renal disease (ESRD) living in the rural communities who decided to decline or accept dialysis upon counseling.

Methods : We retrospectively interviewed patients with ESRD, or their relatives, at 5 community hospitals in Kamphaeng Phet Province, Thailand during the last 3 years prior to the study. Those who were 18 years or older, had glomerular filtration rate at 10 mL/ min/ 1.73 m2 body surface area or less, had no medical contraindications to dialysis therapy, and had been counseled about dialysis modalities, were enrolled.

Results : At the time of the survey, 134 cases chose to decline (Group 1) and 61 to receive dialysis (Group 2). The Group 1 cases were 10 years older than Group 2 (p<0.001); had higher proportions of cases with limited mobility (30%), or deceased spouses (38%) than Group 2 (6%, p<0.001; and 11%, p<0.0001; respectively). The number of offspring in Group 1 (3.5 + 2.1) was higher than that Group 2 (2.6 + 1.7, p=0.003). The most reason cited by the Group 1 cases for declining dialysis was “not wanting to be a burden to family members” (90%). Their decision relied mostly on their own and on health personal at sub-district health offices, whereas that in Group 2 relied on spouses or offspring, and on dialysis personnel at the provincial hospital.

Conclusion : The majority of rural Thai patients with ESRD who had no medical contraindications preferred to decline dialysis. Age factor, physical limitation, loss of spouses and concern on a treatment burden to family members were causally associated with their decision.

References

Ingsathit A, Thakkinstian A, Chaiprasert A, Sangthawan P,Gojaseni P, Kiattisunthorn K, et al. Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. Nephrol Dial Transplant 2010;25: 1567-75.

Chuengsaman P, Kasemsup V. PD-First Policy: Thailand’s response to the challenge of meeting the needs of patient with end-stage renal disease. Semin Nephrol 2017; 37: 287-95.

Dhanakijcharoen P, Sirivongs D, Aruyapitipan S, Chuengsaman P, Lumpaopong A. The “PD First” policy in Thailand: threeyears experiences (2008–2011). J Med Assoc Thai 2011; 94:S153-61.

The Nephrology Society of Thailand. Thailand Renal Replacement Therapy.[Internet]2015. Available from: http://www.nephrothai.org/images/Final RRT report_2015.pdf.

Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 2015; 385: 1975-82.

Chan HW, Clayton PA, McDonald SP, Agar JW, Jose MD. Risk factors for dialysis withdrawal: an analysis of the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry,1999- 2008. Clin J Am Soc Nephrol 2012; 7: 775-81.

Wetmore JB, Yan H, Gilbertson D, Liu J. Factors associated with elective withdrawal of maintenance hemodialysis: a casecontrol study. Am J Nephrol 2020; 51:227-36.

Wetmore JB, Yan J, Hu Y, Gilbertson D, Liu J. Factors associated ทwith withdrawal from maintenance dialysis: a case-control analysis. Am J kidney Dis 2018; 71: 831-41.

Chen JC, Thorsteinsdottir B, Vaughan LE, Feely MA, Albright RC, Onuigbo M, et al. End of life, withdrawal, and palliative care utilization among patients receiving maintenance hemodialysis therapy. Clin J Am Soc Nephrol 2018; 13: 1172-9.

Bajwa K, Szabo E, Kjellstrand CM. A prospective study of riskfactors and decision making in discontinuation of dialysis.Arch Intern Med 1996; 156: 2571-7.

McDade-Montez EA, Christensen AJ, Cvengros JA, Lawton WJ. The role of depression symptoms in dialysis withdrawal.Health Psychol 2006; 25:198-204.

Arogundade FA, Sanusi AA, Hassan MO, Akinsola A. The pattern,clinical characteristics and outcome of ESRD in Ile-lfe, Nigeria:is there a change in trend ? Afr Health Sci 2011: 11:594-601.

Ellwood AD, Jassal SV, Suri RS, Clark WF, Na Y, Moist LM. Early dialysis initiation and rates and timing of withdrawal from dialysis in Canada. Clin J Am Soc Nephrol 2013; 8: 265-70.

Sehgal AR, Weisheit C, Miura Y, Butzlaff M, Kielstein R, Taguchi Y. Advance directives and withdrawal of dialysis in the United States, Germany, and Japan. JAMA1996; 276: 1652 –6.

Lo WK, Li FK, Choy CB, Cheng SW, Chu WL, Ng SY, et al. A retrospective survey of attitudes toward acceptance of peritoneal dialysis in Chinese end-stage renal failure patients in Hong Kong. Perit Dial Int 2001; 21: S318-21.

Da Silva-Gane M, Wellsted D, Greenshields H, Norton S, Chandna SM, Farrington K. Quality of life and survival in patients with advanced kidney failure managed conservatively or by dialysis. Clin J Am Soc Nephrol 2012; 7: 2002-9.

Yong DSP, Kwok AOL, Wong DML, Suen MHP, Chen WT, Tse DMW. Symptom burden and quality of life in end-stage renal diseases: a study of 179 patients on dialysis and palliative care. Palliat Med 2009; 23: 111-9.

Yuen SK, Suen HP, Kwok OL, Yong SP, Tse MW. Advance care planning for 600 Chinese patients with end-stage renal disease. Hong Kong J Nephrol 2016; 19: 19-27.

Hemmelgarn BR, James MT, Manns BJ, O’ Hare AM, Muntner P, Ravani P, et al. Rates of treated and untreated kidney failure in older vs younger adults. JAMA 2012; 307: 2507-15.

Li PK, Chow KM. The cost barrier to peritoneal dialysis in the developing world - an Asian Perspective. Perit Dial Int 2001; 21: S307-13.

Dodd R, Palagyi A, Guild L, Jha V, Jan S. The impact of out-ofpocket costs on treatment commencement and adherence in chronic kidney disease: a systematic review. Health Policy Plan 2018; 33: 1047-54.

Prakongsai P, Palmer N, Uay-Trakul P, Tangcharoensathien V,Mills A. The implication of benefit package design: the impact on poor Thai households of excluding renal replacement therapy. J Int Development 2009; 21:291-308

United Nations, Department of Economic and Social Affairs.World Population Prospect 2019.[Internet]2019.Available from: https://population.un.org/wpp/Graphs/Probabilistic/OADR/65plus/15-64/764.

Edelglass W, Garfield J, editors. Buddhist Philosophy: Essential Readings. Oxford: Oxford University Press;2009.

Saisunantararom W, Cheawchanwattana A , Kanjanabuch T,Buranapatana M, Chanthapasa K. Associations among spirituality, health-related quality of life, and depression in pre-dialysis chronic kidney disease patients:an exploratoryanalysis in Thai Buddhist patients. Religions 2015; 6: 1249-62.

Rusa SG, Peripato GI, Pavarini SC, Inouye K, Zazzetta MS, Orlandi Fde S. Quality of life/spirituality, religion and personal beliefs of adult and elderly chronic kidney patients under hemodialysis. Rev Lat Am Enfermagem 2014; 22: 911-7.

The World Bank. Life expectancy at birth, total (years) – Thailand.[Internet] 2019. Available from: https://data.worldbank.org/indicator/SP.DYN.LE00.IN?locations=TH&view=chart.

Orimo H. Reviewing the definition of elderly. Nihon Ronen Igakkai Zasshi 2006; 43: 27-34.

Bowman KW, Hui EC. Bioethics for clinicians: 20. Chinese bioethics. CMAJ 2000; 163: 1481-5.

Lai CF, Tsai HB, Hsu SH, Chiang CK, Huang JW, Huang SJ.Withdrawal from long-term hemodialysis in patients withend-stage renal disease in Taiwan. J Formos Med Assoc 2013; 112: 589-99.

Tanaka M, Kodama S. Legal policy challenges in withdrawal of dialysis treatment in Japan. Eur J Public Health 2019; 29:168.

Tsai HB, Chen DR. Clinical practice in the hospice care for end-stage renal disease. Taiwan Hospice Organization and Taiwan Academy of Hospice palliative Medicine 2011 Annual Meeting (2011), Taipei: Taiwan; 2011.

Prasad N, Jha V. Hemodialysis in Asia. Kidney Dis 2015;1:165-177.

Wu H, Li Q, Cai Y, Zhang J, Cui W, Zhou Z. Economic burden and cost-utility analysis of three renal replacement therapies in ESRD patients from Yunnan Province, China. Int Urol Nephrol 2020; 52: 573–9.

Downloads

Published

10-03-2021

How to Cite

1.
Jukkapong, Prommachat K, Promnim S, Boonyuen N, Intapong J, Meesiri P, Leesmidt V, Tungsanga K. A Retrospective Comparison of Thai patients with End-stage Renal Disease Who Chose to Decline or Receive Dialysis Therapy. J DMS [Internet]. 2021 Mar. 10 [cited 2024 Nov. 18];45(4):111-2. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/249787

Issue

Section

Original Article