The Effect of Mesenchymal Stem Cells on Peri-implant Defect Healing in Animal Studies: A Systematic Review and Meta-analysis
Keywords:
Dental implants, Mesenchymal stem cells, Tissue engineering, Meta-analysisAbstract
Background : The ultimate goal of peri-implant defect healing is the regeneration and establishiment of osteointegration. As the limitation of the autogenous bone graft which is considered to be a gold standard treatment, tissue engineering technique was created for an alternative treatment. Mesenchymal stem cells provide a promising approach for bone regeneration inducing and osseointegration enhancing with tissue engineering technology.Objective : The objective of meta-analysis was to quantitatively find out the effect of mesenchymal stem cells for peri-implant defect healing in animal model.Methods : PubMed database was systematically searched for related articles, together with searching in Google scholar. They were all filtered for articles in English or Thai from 2000 to May 2020.Results : Twelve articles, which are randomized controlled trials and preclinical animal trials were accepted and extracted for meta-analysis. Data was calculated for standard mean difference (SMD) at 95% CI and random effect model was used. the results showed that mesenchymal stem cell groups had positive results on bone formation (SMD=2.683; 95% CI= 1.580 – 3.786, p=0.000) and bone-to-implant contact (SMD=2.592; 95% CI = 1.363 – 3.821, p = 0.000). However, the data was high heterogeneity (I2=80.4%, I2=83.5%).Conclusion : The result evidences suggest that the mesenchymal stem cells might had benefits on peri-implant defect healing in animals. However, as less preclinical animal trials and possible the risk of bias problems, the further higher quality researches and randomized controlled trials in animal models are still required to prove the effectiveness of mesenchymal stem cells for the healing of peri-implant defect in clinical applications in the future.
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