The Evaluation of Saccular Function in Definite Meniere’s Disease Patients by Cervical Vestibular Evoked Myogenic Potentials (cVEMPs)


  • Juthaporn Phlaichan, M.D. ฝ่ายบริการทางการแพทย์สำนักงานบรรเทาทุกข์และประชานามัยพิทักษ์
  • Paninee Charusripan, M.D. ภาควิชาโสต ศอ นาสิกวิทยา คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
  • Permsarp Isipradit, M.D. ภาควิชาโสต ศอ นาสิกวิทยา คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย


Meniere’s disease, Saccular function, Vestibular-evoked myogenic potential


Background : Meniere’s disease demonstrates abnormal function of both auditory and vestibular system. Abnormalities in saccule was the second most common finding in histopathology study. The previous studies showed inconsistent results in saccular function.

Objective : To evaluate saccular function in definite Meniere’s disease patients by cervical vestibular evoked myogenic potential (cVEMP).

Method : A cross-sectional study conducted at King Chulalongkorn Memorial Hospital. All patients in control group and definite Meniere’s disease underwent cVEMP. Four parameters of cVEMP include P1 latency, N1 latency, P1-N1 amplitude and amplitude asymmetry ratio were evaluated.

Result : Twenty-two definite Meniere’s disease and thirty control patients were included in the study. The median duration of Meniere’s disease was 36 months. Nineteen of twenty-two Meniere’s disease patients (86.36%) obtained absence cVEMP in affected ear. The mean latency of P1, N1 and P1-N1 amplitude were not statistically significant different between control group and unaffected ear of Meniere’s disease group (mean difference = 0.73, 95% CI = -1.55, 0.08, p = 0.074; mean difference = 0.25, 95% CI = -1.23, 0.74, p = 0.62; mean difference = -5.45, 95% CI -1.44, 12.34, p = 0.12, respectively). Three Meniere’s disease patients who cVEMP presented in affected ear showed amplitude asymmetry ratio of 24.4%.

Conclusions : Patients with definite Meniere’s disease usually demonstrated absent cVEMP response.


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How to Cite

Phlaichan จ, Charusripan ภ, Isipradit เ. The Evaluation of Saccular Function in Definite Meniere’s Disease Patients by Cervical Vestibular Evoked Myogenic Potentials (cVEMPs). j dept med ser [Internet]. 2021 Jun. 18 [cited 2022 Aug. 14];46(1):176-81. Available from:



Original Article