Ductal Carcinoma-in-situ Arising within Fibroadenoma of the Breast: A Case Report, Mammographic, Sonographic and Dynamic Contrast-enhanced Breast MRI Features


  • Ananya Gonthong, M.D. Lopburi Cancer Hospital


Ductal carcinoma in situ (DCIS), Fibroadenoma, Fine pleomorphic calcification


A 38-year-old woman was diagnosed with invasive ductal carcinoma in the left breast status, following left modified radical mastectomy and chemotherapy lasting 1 year. She had undergone annual surveillance mammography and ultrasonography. Mammography revealed developed fine pleomorphic calcification within the mass and correlated Color Doppler study demonstrated internal vascularity. Core needle biopsy was done and pathological report of ductal carcinoma in situ with fibroadenoma. Pre-operative MRI was obtained. Finally, pathological diagnosis after right simple mastectomy revealed ductal carcinoma in situ arising in fibroademona, that is rare disease.


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Dabbs DJ. Breast Pathology. Philadelphia, PA: Elsevier Health Sciences; 2012. p.816.

Rosen PP. Rosen’s breast pathology. 2 ed. Philadelphia PA, USA:Lippincott Williams & Wilkins; 2001.

Goel NB, Knight TE, Pandey S, Riddick-Young M, de Paredes ES, Trivedi A. Fibrous lesions of the breast:imaging-pathologic correlation. Radiographics 2005;25:1547-59.

Gordon PB, Gagnon FA, Lanzkowsky L. Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy:acceptable rates of growth at long-term follow-up. Radiology 2003;229:233-8.

Buzanowski-Konakry K, Harrison EG, Jr., Payne WS. Lobular carcinoma arising in fibroadenoma of the breast.Cancer 1975;35:450-6.

Deschenes L, Jacob S, Fabia J, Christen A. Beware of breast fibroadenomas in middle-aged women. Can J Surg 1985;28:372-4.

Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD Jr, Rados MS, et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med 1994;331:10-5.

Shin JH, Choi HY, Lee SN, Kim YJ. Microinvasive ductal carcinoma arising within a fibroadenoma: a case report.Acta Radiol 2006;47:643-5.

Diaz NM, Palmer JO, McDivitt RW. Carcinoma arising within fibroadenomas of the breast. A clinicopathologic study of 105 patients. Am J Clin Pathol 1991;95:614-22.

Abe H, Hanasawa K, Naitoh H, Endo Y, Tani T, Kushima R. Invasive ductal carcinoma within a fibroadenoma of the breast. Int J Clin Oncol 2004;9:334-8.

Gollapalli V BAKSS, Gilchrist B. DCIS Breast Arising in a Fibroadenoma-Case Report of a Rare Condition. Clin Surg 2017;2:1312.

Ooe A, Takahara S, Sumiyoshi K, Yamamoto H, Shiba E, Kawai J.Preoperative diagnosis of ductal carcinoma in situ arising within a mammary fibroadenoma: a case report. Jpn J Clin Oncol 2011;41:918-23.

Park EK, Cho KR, Seo BK, Woo OH, Lee JH, Song SE, et al.Radiologic Findings of Ductal Carcinoma in Situ Arising Within a Juvenile Fibroadenoma: Mammographic, Sonographic and Dynamic Contrast-Enhanced Breast MRI Features. Iran J Radiol 2015;12:e17916.

Rao S, Latha PS, Ravi A, Thanka J. Ductal carcinoma in a multiple fibroadenoma: diagnostic inaccuracies. J Cancer Res Ther 2010;6:385-7.

Wu YT, Wu HK, Chen ST, Chen CJ, Chen DR, Lai HW.Fibroadenoma progress to ductal carcinoma in situ,infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case. J Surg Case Rep 2017;2017:rjx064.

Zeeshan SS, Sabeehuddin & Riaz, Nazia. Ductal Carcinoma-in-situ within fibroadenoma of the breast: A case report with literature review. International Journal of Case Reports and Images 2018;9.

Greenwood HI, Heller SL, Kim S, Sigmund EE, Shaylor SD, Moy L. Ductal carcinoma in situ of the breasts:review of MR imaging features. Radiographics 2013;33:1569-88.

Wang LC, Sullivan M, Du H, Feldman MI, Mendelson EB. US appearance of ductal carcinoma in situ.Radiographics 2013;33:213-28.

Mossa-Basha M, Fundaro GM, Shah BA, Ali S, Pantelic MV. Ductal carcinoma in situ of the breast: MR imaging findings with histopathologic correlation. Radiographics 2010;30:1673-87.

Yamada T, Mori N, Watanabe M, Kimijima I, Okumoto T, Seiji K,et al. Radiologic-pathologic correlation of ductal carcinoma in situ. Radiographics 2010;30:1183-98.



How to Cite

Gonthong A. Ductal Carcinoma-in-situ Arising within Fibroadenoma of the Breast: A Case Report, Mammographic, Sonographic and Dynamic Contrast-enhanced Breast MRI Features. j dept med ser [Internet]. 2021 Sep. 3 [cited 2022 Sep. 28];46(2):151-8. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/253587



Case Report