Effectiveness of the Chemotherapy Drug Preparation Robot Accuracy and Precision and Working Time for Injectable Anticancer Drugs in Udon Thani Cancer Hospital Patients


  • Araya Lukanawonakul Udon Thani Cancer Hospital
  • Thitikan Siripakornkan Udon Thani Cancer Hospital
  • Tharatorn Tungkasamit Udon Thani Cancer Hospital


Chemotherapy-compounding robot, Chemotherapy, Robot


Background: The demand for chemotherapy in the treatment of cancer is on the rise, placing a significant burden on medical personnel responsible for drug preparation and mixing. Udon Thani Cancer Hospital has initiated the use of chemotherapy-compounding robots to replace the work of staff in chemotherapy preparation rooms, as well as to be safer for operators. Objective: This study aimed to assess the efficiency of the chemotherapy drug preparation robot for injectable anticancer drugs regarding the accuracy and time used for drug preparation. Method: A retrospective study of parallel data collection and ordered dose of chemotherapy through the robot was conducted to evaluate the accuracy of the required chemotherapy dose by weighing the vial before and after aspiration. Then, an analysis of the difference between the amount of drug required and the amount of drug was done and reported as a percentage. Additionally, drug preparation time, from the robot’s initiation of checking drug size and type to the completion of mixing, was recorded. Result: From collected 1,221 drug preparations from 1 March 2022 to 30 September 2022, the median percentage error of drug preparation was 0.0 (min = -2.69, max = 4.06). The total preparation time, counted from checking the dosage and type of drugs ordered until mixing completion, was 15.1gif.latex?\pm6.9 minutes. The result was independent of the required drug volume, and the size of the syringe used. Furthermore, the result had no difference from when the drug was mixed by a medical professional. Conclusion: The chemotherapy-compounding robot can be used accurately and timely. It can replace operations by personnel to reduce exposure to chemotherapy drugs.


Rojanamatin J, Ukranun W, Suppattagorn P, Chiawiriyabunya I, Wongsena M, Chaiwerawattana A, et al. Cancer in Thailand Vol X, 2016-2018. Bangkok. National Cancer Institute; 2021.

Lyman GH. Impact of chemotherapy dose intensity on cancer patient outcomes. J Natl Compr Canc Netw 2009;7(1):99-108.

Zhang XH, Hao S, Gao B, Tian WG, Jiang Y, Zhang S, et al. A network meta-analysis for toxicity of eight chemotherapy regimens in the treatment of metastatic/advanced breast cancer. Oncotarget 2016;7(51):84533-43.

Ford CD, Killebrew J, Fugitt P, Jacobsen J, Prystas EM. Study of medication errors on a community hospital oncology ward. J Oncol Pract 2006;2(4):149-54.

Roussel C, Connor TH. Chemotherapy and Pharmacy: A toxic mix?.TOP THE ONCOLOGYY PHAMACIST 2013;6(2):32-3.

Riestra AC, López-Cabezas C, Jobard M, Campo M, Tamés MJ, Marín AM, et al. Robotic chemotherapy compounding: A multicenter productivity approach. J Oncol Pharm Pract 2022;28(2):362-72.

Iwamoto T, Morikawa T, Hioki M, Sudo H, Paolucci D, Okuda M. Performance evaluation of the compounding robot, APOTECA chemo, for injectable anticancer drugs in a Japanese hospital. J Pharm Health Care Sci 2017;3:12.

US Pharmacopeial Convention (USP). Pharmaceutical compunding-sterile preparations. [Internet] 2013. [cited 2023 Mar 10]. Available from: https://www.sefh.es/fichadjuntos/ USP797GC.pdf

Bhakta SB, Colavecchia AC, Coffey W, Curlee DR, Garey KW. Implementation and evaluation of a sterile compounding robot in a satellite oncology pharmacy. Am J Health Syst Pharm 2018;75(11 Supplement 2):S51-7.

Seger AC, Churchill WW, Keohane CA, Belisle CD, Wong ST, Sylvester KW, et al. Impact of robotic antineoplastic preparation on safety, workflow, and costs. J Oncol Pract 2012;8(6):344-9.

Nurgat Z, Faris D, Mominah M, Vibar A, Al-Jazairi A, Ewing S, et al. A three-year study of a first-generation chemotherapycompounding robot. Am J Health Syst Pharm 2015;72(12): 1036-45.

Yaniv AW, Orsborn A, Bonkowski JJ, Chew L, Krämer I, Calabrese S, et al. Robotic i.v. medication compounding: Recommendations from the international community of APOTECAchemo users. Am J Health Syst Pharm 2017;74(1):e40-6.

Yaniv AW, Knoer SJ. Implementation of an i.v.-compounding robot in a hospital-based cancer center pharmacy. Am J Health Syst Pharm 2013;15;70(22):2030-7.

Capilli M, Enrico F, Federici M, Comandone T. Increasing pharmacy productivity and reducing medication turnaround times in an Italian comprehensive cancer center by implementing robotic chemotherapy drugs compounding. J Oncol Pharm Pract 2022;28(2):353-61.




How to Cite

Lukanawonakul A, Siripakornkan T, Tungkasamit T. Effectiveness of the Chemotherapy Drug Preparation Robot Accuracy and Precision and Working Time for Injectable Anticancer Drugs in Udon Thani Cancer Hospital Patients. J DMS [Internet]. 2023 Dec. 15 [cited 2024 Apr. 15];48(4):47-54. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/261966



Original Article