Correlation between Glomerular Infiltration Rate and Left Ventricular Mass Index in Chronic Kidney Disease Patients

Abstract

Background: Chronic kidney disease induced increases in left ventricular mass index were found to correlate with glomerular filtration rate. The relationship and risk factors of cardiac structure and glomerular filtration rate have not been studied in Thai patients. Objectives: This study was to investigate the correlation between glomerular filtration rate (GFR) and left ventricular mass index in chronic kidney disease (CKD) Thai patients. Methods: This cross-sectional study was conducted at Pranangklao Hospital between January 2016 and December 2021. A total of 248 CKD patients were included in the study. The mean age of the patients was 64.18±14.57 years, and 37.1% of the patients were male. The mean glomerular infiltration rate (GFR) was 57.63±34.22 ml/min/1.73m2, and the mean LVMI was 113.31±41 g/m2. The majority of the patients had hypertension and dyslipidemia and were being treated with statins and beta blockers. Results: Left ventricular mass index (LVMI) was negatively correlated with hematocrit (r = -0.147, p = .02) and GFR (r = -0.283, p < .001) and positively correlated with hypertension (r = 0.228, p < .001), diabetes mellitus (r = 0.173, p = .006), dyslipidemia (r = 0.24, p < .001), coronary artery disease (r = 0.216, p = .001), LVMI (r = 0.947, p < .001), relative wall thickness (r = 0.205, p = .001), left atrial volume index (r = 0.557, p < .001), right atrial pressure (r = 0.161, p = .011), tricuspid regurgitation velocity (r = 0.214, p = .001), right ventricular systolic pressure (r = 0.306, p < .001), and mean pulmonary artery pressure (r = 0.344, p < .001). Conclusion: This study found a significant correlation between GFR and LVMI in Thai CKD patients (r = -0.283). The results suggest that as GFR declines, LVMI increases, which may lead to adverse cardiovascular outcomes.