Malaria Pre-elimination Assessment in Eastern Indonesia

Authors

  • Jontari Hutagalung Field Epidemiology Training Program, Faculty of Medicine, University of Gadjah Mada, Indonesia
  • H Kusnanto Field Epidemiology Training Program, Faculty of Medicine, University of Gadjah Mada, Indonesia
  • Supargiyono Department of Parasitology, Entomology and Tropical Disease, University of Gadjah Mada, Indonesia
  • SA Hamim Department of Biochemistry, University of Gadjah Mada, Indonesia
  • AW Satyagraha Eijkman Institute for Molecular Biology, Indonesia
  • R Novijanti Eijkman Institute for Molecular Biology, Indonesia
  • AG Triwibowo Institute for Vector and Reservoir Control Research and Development, National Institute of Health Research and Development, Ministry of Health, Indonesia
  • MT Prihatin Institute for Vector and Reservoir Control Research and Development, National Institute of Health Research and Development, Ministry of Health, Indonesia
  • Purwono
  • D Ida Department of Biochemistry, University of Gadjah Mada, Indonesia
  • A Bai South Central Timor Health Office, Indonesia
  • I Bansai South Central Timor Health Office, Indonesia
  • S Kikhao South Central Timor Health Office, Indonesia
  • L Hananta Department of Pharmacology and Pharmacy, Faculty of Medicine, University of Catholic Atmajaya, Indonesia

DOI:

https://doi.org/10.59096/osir.v9i1.263221

Keywords:

epidemiology, malaria pre-elimination program, Eastern Indonesia

Abstract

About 4.8 million Indonesians were infected with malaria in 2013 while the infections were mostly in Eastern Indonesia. Indonesia Ministry of Health announced that malaria pre-elimination stage should be reached by 2015-2020 and free of malaria transmission by 2030 in Eastern Indonesia. Although detailed maps of epidemiological distribution, prevalence and risk factors for malaria were needed, there was limited access to routine surveillance data such as annual parasitic incidence and surveillance report. Hence, this study aimed to assess the epidemiological situation of this area. Total 555 people who aged 14 years and above, and lived in one of five districts in Eastern Indonesia were enrolled in this study. About 32.6% (181/555) were tested positive for malaria by nested polymerase chain reaction, with Plasmodium vivax as the dominant species. Not using bed nets was the most significant risk factors. Spatial analysis indicated three distinguished clusters (180, 229 and 88 cases). Hence, malaria pre-elimination program in Eastern Indonesia should be postponed as the situation did not meet the criteria yet. Routine treatment to stop silent transmission, scaling up control measures and improving laboratory surveillance were needed before pre-elimination.

References

Indonesia. Ministry of Health. Communicable Diseases and Environment Health Division. Malaria in Indonesia. Jakarta: Communicable Diseases and Environment Health Division; 2013. p. 5-10. Indonesian.

Elyazar IR, Hay SI, Baird JK. Malaria distribution, prevalence, drug resistance and control in Indonesia. Adv Parasitol. 2011;74:41-175.

East Nusa Tenggara Health Office. Health profile of East Nusa Tenggara Province, 2012-2013. Kupang: East Nusa Tenggara Health Office; 2013. p. 15-20. Indonesian.

Asia Pacific Leaders Malaria Alliance. An Asia-Pacific free of malaria by 2030. 2015 Apr 23 [cited 10 Feb 2016]. <http://aplma.org/events/16/An-Asia-Pacific-Free-of-Malaria-by-2030/#sthash.xxOTvKuU.dpuf>

Indonesia. Ministry of Health. National presentation: management, control and treatment for malaria in Indonesia. Jakarta: Ministry of Health, Indonesia; 2014. p.5-10. Indonesian.

Smith DL, Cohen JM, Chiyaka C, Johnston G, Gething PW, Gosling R, et al. A sticky situation: the unexpected stability of malaria elimination. Philos Trans R Soc Lond B Biol Sci. 2013 Jun 24;368(1623):20120145. Print 2013 Aug 5.

Maharaj R, Morris N, Seocharan I, Kruger P, Moonasar D, Mabuza A, et al. The feasibility of malaria elimination in South Africa. Malar J. 2012 Dec 19;11:423.

Feachem RG, Phillips AA, Targett GA, Snow RW. Call to action: priorities for malaria elimination. Lancet. 2010 Nov 6;376(9752):1517-21. Epub 2010 Oct 28.

Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, et al. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J. 2011 Dec 20;10:378.

Elyazar IR, Gething PW, Patil AP, Rogayah H, Sariwati E, Palupi NW, et al. Plasmodium vivax malaria endemicity in Indonesia in 2010. PLoS One. 2012;7(5):e37325. Epub 2012 May 17.

Health Office of South Central Timor. Health profile of South Central Timor District, 2012-2013. Soe: Health Office of South Central Timor; 2014. p. 25-9. Indonesian.

Syafruddin D, Krisin, Asih P, Sekartuti, Dewi RM, Coutrier F, et al. Seasonal prevalence of malaria in West Sumba district, Indonesia. Malar J. 2009 Jan 9;8:8.

Bioneovan Company Limited. Manual for tuberculosis (TB) IgG antibody cat. no. BG-401-C. Beijing: Bioneovan Company Limited; 2013. p. 1-3.

Reszon Diagnostics International. Manual for TYPHIDOT rapid IgM (a rapid test for detection of typhoid fever) cat. no. TF-RD0101. Subang Jaya: Reszon Diagnostics International; 2011. p. 1-2.

HemoCue. Operating manual for HemoCue Hb 201. Angelholm: HemoCue; 2013.

Garmin International Inc. Owner’s manual for GPS MAP Garmin 76. Olathe: Garmin International Inc; 2006.

Indonesia. Ministry of Health. Eijkman Institute. Laboratories assessment of malaria diagnosis in Indonesia: guidelines for participants. Jakarta: Eijkman Institute for molecular; 2010. p. 15-27. Indonesian.

BD Life Sciences. Pre-analytical systems: product catalog 1. New Jersey: BD Life Sciences; 2015.

Promega Corporation. Wizard® genomic DNA purification kit: instruction manual, cat. no. A-1120. Madison: Promega Corporation; 2014.

Promega Corporation. Go tag green master mix PCR: instruction manual, cat. no. M-7122. Madison: Promega Corporation; 2014.

Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Mol Biochem Parasitol. 1993 Apr;58(2):283-92.

BIORON GmbH. Agarose 100 g, molecular biology: manual for cat. no. S-604001. Ludwigshafen: BIORON GmbH; 2012.

Promega Corporation. Ethidium bromide solution cat. no. H-5041. Madison: Promega Corporation; 2015.

Vivantis Technologies Sdn Bhd. Manual: DNA ladder and maker VC 100 bp. Subang Jaya: Vivantis Technologies Sdn Bhd; 2012.

Reid H, Vallely A, Taleo G, Tatem AJ, Kelly G, Riley I, et al. Baseline spatial distribution of malaria prior to an elimination programme in Vanuatu. Malar J. 2010 Jun 2;9:150.

Howes RE, Piel FB, Patil AP, Nyangiri OA, Gething PW, Dewi M, et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med. 2012;9(11):e1001339. Epub 2012 Nov 13.

Guerra CA, Gikandi PW, Tatem AJ, Noor AM, Smith DL, Hay SI, et al. The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide. PLoS Med. 2008 Feb;5(2):e38.

Indonesia. Ministry of Health. Communicable Diseases and Environment Health Division. Guidelines: management of malaria cases in Indonesia. Jakarta: Communicable Diseases and Environment Health Division; 2010. p. 3-9. Indonesian.

Indonesia. Ministry of Health. Communicable Diseases and Environment Health Division. Hand book on management of malaria. Jakarta: Communicable Diseases and Environment Health Division; 2010: p. 30-39. Indonesian.

Domingo GJ, Satyagraha AW, Anvikar A, Baird K, Bancone G, Bansil P, et al. G6PD testing in support of treatment and elimination of malaria: recommendations for evaluation of G6PD tests. Malar J. 2013 Nov 4;12:391.

Hay SI, Okiro EA, Gething PW, Patil AP, Tatem AJ, Guerra CA, et al. Estimating the global clinical burden of Plasmodium falciparum malaria in 2007. PLoS Med. 2010 Jun 15;7(6):e1000290.

Noor AM, Alegana VA, Patil AP, Snow RW. Predicting the unmet need for biologically targeted coverage of insecticide-treated nets in Kenya. Am J Trop Med Hyg. 2010 Oct;83(4):854-60.

Herdiana H, Fuad A, Asih PB, Zubaedah S, Arisanti RR, Syafruddin D, et al. Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia Malar J. 2013 Jan 30;12:42.

Smith DL, Smith TA, Hay SI. Measuring malaria for elimination. In: Feachem RGA, Phillips AA, Targett GA. Shrinking the malaria map: a prospectus on malaria elimination. San Francisco: The Global Health Group; 2009. p. 108-26.

White NJ, Qiao LG, Qi G, Luzzatto L. Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common. Malar J. 2012 Dec 14;11:418.

Omumbo JA, Hay SI, Snow RW, Tatem AJ, Rogers DJ. Modelling malaria risk in East Africa at high-spatial resolution. Trop Med Int Health. 2005 Jun;10(6):557-66.

Published

2016-03-31

How to Cite

Hutagalung, J., Kusnanto, H., Supargiyono, Hamim, S., Satyagraha, A., Novijanti, R., Triwibowo, A., Prihatin, M., Purwono, Ida, D., Bai, A., Bansai, I., Kikhao, S., & Hananta, L. (2016). Malaria Pre-elimination Assessment in Eastern Indonesia. Outbreak, Surveillance, Investigation & Response (OSIR) Journal, 9(1), 1–7. https://doi.org/10.59096/osir.v9i1.263221

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Section

Original article