Prevalence of HIV in Leprosy Patients in Central Myanmar during 2008

Authors

  • Khaing Win Htun Department of Medical Research (Central Myanmar), Ministry of Health, Myanmar
  • N Lin Department of Medical Research (Central Myanmar), Ministry of Health, Myanmar
  • K Myint National Leprosy Control Program, Department of Health, Ministry of Health, Myanmar
  • O Thein Department of Medical Research (Central Myanmar), Ministry of Health, Myanmar
  • M M Lwin Department of Medical Research (Central Myanmar), Ministry of Health, Myanmar
  • M Khin Department of Medical Research (Lower Myanmar), Ministry of Health, Myanmar
  • Y Y Myint Department of Medical Research (Central Myanmar), Ministry of Health, Myanmar
  • H N Oo Department of Medical Research (Central Myanmar), Ministry of Health, Myanmar

DOI:

https://doi.org/10.59096/osir.v6i2.263337

Keywords:

HIV, leprosy, coinfection, Myanmar

Abstract

HIV infection has been shown to be strongly associated with the development of active tuberculosis. However, its association with leprosy was much less clear. Moreover, seroprevalence of HIV infection among leprosy patients has never been reported in Myanmar. This study aimed to determine the seroprevalence of HIV among leprosy patients and the association between HIV infection and types of leprosy in central Myanmar during 2008. A total of 299 leprosy patients, including 242 multibacillary (MB) and 57 paucibacillary (PB) leprosy patients, were enrolled. The overall HIV seroprevalence was 3.7%, with 4.1% in MB leprosy patients and 1.8% in PB leprosy patients. Fifty MB leprosy patients (20.7%) had history of multi-drug therapy (MDT) and 4 of them (8.0%) were HIV infected. Six out of 192 MB leprosy patients without history of MDT were HIV infected (3.1%). MB leprosy cases with history of previous treatment had greater prevalence of HIV infection. Further study should be considered whether HIV infection may cause difficulty to cure leprosy and additional MDT course may require in HIV infected leprosy patients with previous history of MDT.

References

Myint K. Success story in Myanmar Leprosy Elimination Program. Jpn J Lepr. 2005;74(2):93.

World Health Organization. Global leprosy situation, 2011. Weekly Epidemiological Record. 2012 Aug 24;87(34):317-328. [cited 2013 Feb 6]. <http://www.who.int/wer/2012/wer8734.pdf>

Hussain T, Kulshreshtha K, Ghei SK, Natarajan M, Katoch K, Sengupta U. HIV seroprevalence in leprosy patients. Int J Lepr Other Mycobact Dis. 2000 Mar;68(1):67-9.

Vinay K, Smita J, Nikhil G, Neeta G. Human immunodeficiency virus and leprosy coinfection in Pune, India. J Clin Microbiol. 2009 Sep;47(9):2998-9. Epub 2009 Jul 22. [cited 2013 Feb 6]. <http://jcm.asm.org/content/47/9/2998.full>

van den Broek J, Chum HJ, Swai R, O'Brien RJ. Association between leprosy and HIV infection in Tanzania. Int J Lepr Other Mycobact Dis. 1997 Jun;65(2):203-10.

Kalu W. Effect of HIV infection on the clinical response of leprosy in Northern Nigeria – a study done in 2005. Retrovirology. 2006;3(Suppl 1):32. [cited 2013 Feb 6]. <http://www.retrovirology.com/content/3/S1/P32>

Ustianowski AP, Lawn SD, Lockwood DN. Interactions between HIV infection and leprosy: a paradox. Lancet Infect Dis. 2006 Jun;6(6):350-60. [cited 2013 Feb 5]. <http://www.ncbi.nlm.nih.gov/pubmed/16728321>

Groenen G, Saunderson P, Ji BH. How to do a skin smear examination for leprosy. ILEP, 2003. [cited 2013 Feb 5]. <http://www.ilep.org.uk/fileadmin/uploads/Documents/Learning_Guides/lg3eng.pdf>

The International Federation of Anti-Leprosy Associations. Basic statistics of leprosy in Myanmar. [cited 2013 Feb 5]. <http://www.ilep.org.uk/ilep-coordination/leprosy-around-theworld/asia/myanmar/basic-statistics/>

Moet FJ, Meima A, Oskam L, Richardus JH. Risk factors for the development of clinical leprosy among contacts, and their relevance for targeted interventions. Lepr Rev. 2004 Dec;75(4):310-26. [cited 2013 Feb 5]. <http://www.ncbi.nlm.nih.gov/pubmed/15682969>

Sales AM, Ponce de Leon A, Düppre NC, Hacker MA, Nery JA, Sarno EN, et al. Leprosy among patient contacts: a multilevel study of risk factors. PLoS Negl Trop Dis. 2011 Mar 15;5(3):e1013. [cited 2013 Feb 5]. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057944/>

The International Federation of Anti-Leprosy Associations. How to recognize and manage leprosy reactions. London: ILEP, 2002. p. 33-41. [cited 2013 Feb 5]. <http://www.ilep.org.uk/fileadmin/uploads/Documents/Learning_Guides/lg2eng.pdf>

UNAIDS. National AIDS Programme. Global AIDS response progress report, Myanmar, 2012. 2012 Mar 31. [cited 2013 Feb 7]. <https://www.unaids.org/en/dataanalysis/knowyourresponse/countryprogressreports/2012countries/ce_MM_Narrative_Report.pdf>

Moses AE, Adelowo KA, Ajayi BB. Prevalence of HIV-1 infection among patients with leprosy and pulmonary tuberculosis in a semiarid region, Nigeria. J R Soc Promot Health. 2003 Jun;123(2):117-9. [cited 2013 Feb 7]. <http://rsh.sagepub.com/content/123/2/117.abstract>

United Nations Regional Task Force on Injecting Drug Use and HIV/AIDS for Asia and the Pacific. Myanmar country advocacy brief: injecting drug use and HIV. [cited 2013 Feb 5]. <http://www.unodc.org/documents/southeastasiaandpacific/topics/hivaids/UNRTF/Mya_CAB_04_Feb_10_.pdf>

Sarno EN, Illarramendi X, Nery JA, Sales AM, Gutierrez-Galhardo MC, Penna ML, et al. HIV-M. leprae interaction: can HAART modify the course of leprosy? Public Health Rep. 2008 Mar-Apr;123(2):206-12. [cited 2013 Feb 5]. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2239330/>

Pereira GA, Stefani MM, Araújo Filho JA, Souza LC, Stefani GP, Martelli CM. Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in a Brazilian cohort. Am J Trop Med Hyg. 2004 Nov;71(5):679-84. [cited 2013 Feb 5]. <http://www.ajtmh.org/content/71/5/679.full.pdf+html?sid=f3036392-baa7-4bdc-9496-ad1148716698>

Hussain T, Sinha S, Kulshreshtha KK, Katoch K, Yadav VS, Sengupta U, Katoch VM. Seroprevalence of HIV infection among leprosy patients in Agra, India: trends and perspective. Int J Lepr Other Mycobact Dis. 2005 Jun;73(2):93-9. [cited 2013 Feb 5]. <http://www.ilep.org.uk/fileadmin/uploads/Country_Pages/Madagascar/INTERNATIONAL_JOURNAL_OF_LEPROSY.htm>

United Nations site for the MDG Indicators. Antiretroviral therapy coverage among people with advanced HIV infection, percentage. 2012 Jul 2. [cited 2013 Feb 5]. <http://mdgs.un.org/unsd/mdg/Data.aspx>

Published

2013-06-27

How to Cite

Htun, K. W., Lin, N., Myint, K., Thein, O., Lwin, M. M., Khin, M., Myint, Y. Y., & Oo, H. N. (2013). Prevalence of HIV in Leprosy Patients in Central Myanmar during 2008. Outbreak, Surveillance, Investigation & Response (OSIR) Journal, 6(2), 13–18. https://doi.org/10.59096/osir.v6i2.263337

Issue

Section

Original article