A bullous lesion of coexisting lichen sclerosus and morphea: An unusual case report in Thai patient

Authors

  • Wikanda Panmanee DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND
  • Suthinee Rutnin DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND

Keywords:

coexisting of lichen sclerosus and morphea, lichen sclerosus, morphea

Abstract

Lichen sclerosus is a chronic inflammatory dermatosis with anogenital and extraanogenital manifestations. Morphea is a connective tissue disease characterized by sclerosis of the skin and underlying tissues. The coexistence of lichen sclerosus and morphea has sporadically been reported in the literatures. The most reported cases were presented in different locations. We report a case of a 21-year-old-Thai woman that presented as unusual bullous lesion from the coexisting of lichen sclerosus and morphea in the same one.

References

Peterson LS, Nelson AM, Su WP, Mason T, O'Fallon WM , Gabriel SE. The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993. The Journal of rheumatology 1997;24:73-80.

Kreuter A. Localized scleroderma. Dermatologic therapy 2012;25:135-47.

Laxer RM , Zulian F. Localized scleroderma. Current opinion in rheumatology 2006;18:606-13.

Morrow PA. A case of symmetrical morphoea attended with the formation of bullae and extensive ulceration. J Cutan Genito-Urin Dis 1896;14:419-27.

Daoud MS, Su WP, Leiferman KM , Perniciaro C. Bullous morphea: clinical, pathologic, and immunopathologic evaluation of thirteen cases. Journal of the American Academy of Dermatology 1994;30:937-43.

Sherman V, McPherson T, Baldo M, Salim A, Gao XH , Wojnarowska F. The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study. Journal of the European Academy of Dermatology and Venereology : JEADV 2010;24:1031-4.

Meyrick Thomas RH, Ridley CM, McGibbon DH , Black MM. Lichen sclerosus et atrophicus and autoimmunity--a study of 350 women. The British journal of dermatology 1988;118:41-6.

Oyama N, Chan I, Neill SM, Hamada T, South AP, Wessagowit V et al. Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet 2003;362:118-23.

Hallel-Halevy D, Grunwald MH, Yerushalmi J , Halevy S. Bullous lichen sclerosus et atrophicus. Journal of the American Academy of Dermatology 1998;39:500-1.

Kreuter A, Wischnewski J, Terras S, Altmeyer P, Stucker M, Gambichler T. Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center. Journal of the American Academy of Dermatology 2012;67:1157-62.

Lutz V, Frances C, Bessis D, Cosnes A, Kluger N, Godet J et al. High frequency of genital lichen sclerosus in a prospective series of 76 patients with morphea: toward a better understanding of the spectrum of morphea. Archives of dermatology 2012;148:24-8.

Forschner A, Metzler G, Rassner G , Fierlbeck G. Morphea with features of lichen sclerosus et atrophicus at the site of a herpes zoster scar: another case of an isotopic response. International journal of dermatology 2005;44:524-5.

Uitto J, Santa Cruz DJ, Bauer EA , Eisen AZ. Morphea and lichen sclerosus et atrophicus. Clinical and histopathologic studies in patients with combined features. Journal of the American Academy of Dermatology 1980;3:271-9.

Patterson JA , Ackerman AB. Lichen sclerosus et atrophicus is not related to morphea. A clinical and histologic study of 24 patients in whom both conditions were reputed to be present simultaneously. The American Journal of dermatopathology 1984;6:323-35.

Shono S, Imura M, Ota M, Osaku A, Shinomiya S , Toda K. Lichen sclerosus et atrophicus, morphea, and coexistence of both diseases. Histological studies using lectins. Archives of dermatology 1991;127:1352-6.

Oikarinen A, Sandberg M, Hurskainen T, Kinnunen T, Kallioinen M. Collagen biosynthesis in lichen sclerosus et atrophicus studied by biochemical and in situ hybridization techniques. Acta dermato-venereologica Supplementum 1991;162:3-12.

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Published

2026-06-10

How to Cite

Panmanee, W., & Rutnin, S. (2026). A bullous lesion of coexisting lichen sclerosus and morphea: An unusual case report in Thai patient. Thai Journal of Dermatology, 28(4), 277–282. retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/282896