Opioids Use in Pregnancy and Its Implications

Main Article Content

Patchareya Nivatpumin


Pregnant women require opioids analgesic
medications to treat various acute and chronic pain
conditions. It is acknowledged that opioids in the maternal
blood are transferred across the placenta to the fetus.
A retrospective study suggested that some opioids used
in periconceptual period and the first trimester of
pregnancy were associated with an increase in neural tube
defect, gastroschisis and congenital heart anomaly in
human fetuses. Chronic use of opioids in pregnancy
through the third trimester can cause neonatal abstinence
syndrome (NAS), that is, the presence of withdrawal
symptoms of opioids in the newborn.
The aim of this article is to review the literatures
related to opioids use in pregnancy, including the potential
teratogenic risks to fetuses and neonatal abstinence
syndrome. It is imperative to emphasize that opioids
should be used in pregnant woman in as low an amount
as possible for effective pain control and only if benefits
to the mother outweigh risks of any possible adverse effect
to the fetus or the newborn.

Article Details

Review articles


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