The Use of Uterotonic Agents and Oxytocin Receptor Desensitization

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Sasima Dusitkasem


The administration of uterotonic agents after delivery of the fetus are recommended to prevent and treatment postpartum uterine atony during caesarean section. However, most clinical trials are performed in healthy parturients undergoing elective cesarean delivery, which have low risk of postpartum hemorrhage. Prolonged exposure to oxytocin for labor augmentation can result in desensitization and down-regulation of its receptor. The aim of this article is to review recent data on the use of oxytocin, carbetocin and second-line uterotonics to obtain adequate uterine tone in women at increased risk of postpartum hemorrhage.


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Review articles


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