การใช้ยากระตุ้นการหดตัวมดลูกในภาวะดื้อยา Oxytocin
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เผยแพร่แล้ว:
ก.พ. 3, 2021
คำสำคัญ:
การผ่าตัดคลอดบุตร, ภาวะมดลูกไม่หดรัดตัว, ยาหดรัดตัวของมดลูก, ภาวะดื้อยา oxytocin
Main Article Content
บทคัดย่อ
การบริหารยาเพิ่มการหดรัดตัวของมดลูกเพื่อป้องกันและ รักษาภาวะมดลูกไม่หดรัดตัว (uterine atony) เป็นสิ่งสำคัญ ที่จะลดการเกิดภาวะตกเลือดหลังคลอด อย่างไรก็ตาม การศึกษาส่วนใหญ่มักทำในผู้ป่วยตั้งครรภ์ที่มีความเสี่ยงต่ำ (low-risk elective case) ซึ่งจะมีความต้องการปริมาณยาที่ แตกต่างจากผู้ป่วยตั้งครรภ์ที่เจ็บครรภ์หรือผ่านการให้ยาเร่ง คลอดมาก่อน เนื่องจากผู้ป่วยดังกล่าวจะเกิดภาวะดื้อยา oxytocin (oxytocin receptor desensitization) บทความนี้ จะรวบรวมการศึกษาในปัจจุบัน เพื่อให้บุคลากรวิสัญญี นำไปเป็นข้อมูลประกอบการตัดสินใจในการบริหารยากระตุ้น การหดตัวของมดลูกที่เหมาะสมเพื่อลดปัญหาการตกเลือด หลังคลอดในผู้ป่วยกลุ่มนี้ได้อย่างมีประสิทธิภาพยิ่งขึ้นต่อไป
Article Details
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บทฟื้นฟูวิชาการ
References
1. Robinson C, Schumann R, Zhang P, Young RC. Oxytocininduced
desensitization of the oxytocin receptor. Am J
Obstet Gynecol 2003;188:497-502.
2. Phaneuf S, Asbóth G, Carrasco MP, et al. The desensitization
of oxytocin receptors in human myometrial cells is
accompanied by down-regulation of oxytocin receptor
messenger RNA. J Endocrinol 1997;154:7-18.
3. Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y,
Balki M. Oxytocin pretreatment decreases oxytocin-induced
myometrial contractions in pregnant rats in a concentrationdependent
but not time-dependent manner. Reprod Sci
2009;16:501-8.
4. Balki M, Cristian AL, Kingdom J, Carvalho JC. Oxytocin
pretreatment of pregnant rat myometrium reduces the
efficacy of oxytocin but not of ergonovine maleate or
prostaglandin F2α. Reprod Sci 2010;17:269-77.
5. Balki M, Erik-Soussi M, Kingdom J, Carvalho JC. Oxytocin
pretreatment attenuates oxytocin-induced contractions in
human myometrium in vitro. Anesthesiology 2013;119:552-61.
6. Balki M, Ramachandran N, Lee S, Talati C. The recovery time
of myometrial responsiveness after oxytocin-induced
desensitization in human myometrium in vitro. Anesth Analg
2016;122:1508-15.
7. Balki M, Erik-Soussi M, Ramachandran N, Kingdom J,
Carvalho JC. The contractile effects of oxytocin, ergonovine,
and carboprost and their combinations: an in vitro study on
human myometrial strips. Anesth Analg 2015;120:1074-84.
8. Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose
requirement after cesarean delivery for labor arrest. Obstet
Gynecol 2006;107:45-50.
9. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin
requirements at elective cesarean delivery: a dose-finding
study. Obstet Gynecol 2004;104:1005-10.
10. Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B.
Minimum effective bolus dose of oxytocin during elective
Caesarean delivery. Br J Anaesth 2010;104:338-43.
11. Lavoie A, McCarthy RJ, Wong CA. The ED90 of prophylactic
oxytocin infusion after delivery of the placenta during
cesarean delivery in laboring compared with nonlaboring
women: an up-down sequential allocation dose-response
study. Anesth Analg 2015;121:159-64.
12. Foley A, Gunter A, Nunes KJ, Shahul S, Scavone BM. Patients
undergoing cesarean delivery after exposure to oxytocin
during labor require higher postpartum oxytocin doses.
Anesth Analg 2018;126:920-4.
13. Drife J, Lewis G. Why mothers die, 1997-1999: The Fifth
Report of the Confidential Enquiries into Maternal Deaths in
the United Kingdom. London: Royal College of Obstetricians
and Gynecologists Press; 2001.
14. Dyer RA, Reed AR, van Dyk D, et al. Hemodynamic effects
of ephedrine, phenylephrine, and the coadministration of
phenylephrine with oxytocin during spinal anesthesia for
elective cesarean delivery. Anesthesiology 2009;111:753-65.
15. Rumboll CK, Dyer RA, Lombard CJ. The use of phenylephrine
to obtund oxytocin-induced hypotension and tachycardia during
caesarean section. Int J Obstet Anesth 2015;24:297-302.
16. Farber MK, Schultz R, Lugo L, Liu X, Huang C, Tsen LC. The
effect of co-administration of intravenous calcium chloride
and oxytocin on maternal hemodynamics and uterine tone
following cesarean delivery: a double-blinded, randomized,
placebo-controlled trial. Int J Obstet Anesth 2015;24:217-24.
17. Thomas JS, Koh SH, Cooper GM. Haemodynamic effects of
oxytocin given as i.v. bolus or infusion on women undergoing
caesarean section. Br J Anaesth 2007;98:116-9.
18. Jonsson M, Hanson U, Lidell C, Nordén-Lindeberg S. ST
depression at caesarean section and the relation to oxytocin
dose. A randomised controlled trial. Br J Obstet Gynaecol
2010;117:76-83.
19. Moran C, Ni Bhuinneain M, Geary M, Cunningham S,
McKenna P, Gardiner J. Myocardial ischaemia in normal
patients undergoing elective caesarean section: a peripartum
assessment. Anaesthesia 2001;56:1051-8.
20. Bergum D, Lonnée H, Hakli TF. Oxytocin infusion: acute
hyponatraemia, seizures and coma. Acta Anaesthesiol
Scand 2009;53:826-7.
21. Sartain JB, Barry JJ, Howat PW, McCormack DI, Bryant M.
Intravenous oxytocin bolus of 2 units is superior to 5 units
during elective caesarean section. Br J Anaesth 2008;101:
822-6.
22. Cole NM, Carvalho JC, Erik-Soussi M, Ramachandran N,
Balki M. In vitro comparative effect of carbetocin and
oxytocin in pregnant human myometrium with and without
oxytocin pretreatment. Anesthesiology 2016;124:378-86.
23. Su LL, Chong YS, Samuel M. Carbetocin for preventing
postpartum haemorrhage. Cochrane Database Syst Rev.
2012;2:CD005457.
24. Nguyen-Lu N, Carvalho JC, Farine D, Seaward G, Ye XY,
Balki M. Carbetocin at cesarean delivery for labour arrest:
a sequential allocation trial to determine the effective dose.
Can J Anaesth 2015;62:866-74.
25. Cordovani D, Balki M, Farine D, Seaward G, Carvalho JC.
Carbetocin at elective cesarean delivery: a randomized
controlled trial to determine the effective dose. Can J Anaesth
2012;59:751-7.
26. Khan M, Balki M, Ahmed I, Farine D, Seaward G, Carvalho
JC. Carbetocin at elective cesarean delivery: a sequential
allocation trial to determine the minimum effective dose. Can
J Anaesth 2014;61:242-8.
27. Anandakrishnan S, Balki M, Farine D, Seaward G, Carvalho
JC. Carbetocin at elective cesarean delivery: a randomized
controlled trial to determine the effective dose, part 2. Can
J Anaesth 2013;60:1054-60.
28. Tabl S, Balki M, Downey K, et al. Uterotonics in elective
caesarean delivery: a randomised non-inferiority study
comparing carbetocin 20 μg and 100 μg. Anaesthesia
2019;74:190-6.
29. Rosseland LA, Hauge TH, Grindheim G, Stubhaug A,
Langesæter E. Changes in blood pressure and cardiac
output during cesarean delivery: the effects of oxytocin and
carbetocin compared with placebo. Anesthesiology 2013;
119:541-51.
30. Moertl MG, Friedrich S, Kraschl J, Wadsack C, Lang U,
Schlembach D. Haemodynamic effects of carbetocin and
oxytocin given as intravenous bolus on women undergoing
caesarean delivery: a randomised trial. Br J Obstet Gynaecol
2011;118:1349-56.
31. Bateman BT, Berman MF, Riley LE, Leffert LR. The epidemiology
of postpartum hemorrhage in a large, nationwide sample of
deliveries. Anesth Analg 2010;110:1368-73.
32. Butwick AJ, Carvalho B, Blumenfeld YJ, El-Sayed YY, Nelson
LM, Bateman BT. Second-line uterotonics and the risk of
hemorrhage-related morbidity. Am J Obstet Gynecol
2015;212:642.e1-642.e6427.
33. Amant F, Spitz B, Timmerman D, Corremans A, Van Assche
FA. Misoprostol compared with methylergometrine for the
prevention of postpartum haemorrhage: a double-blind
randomised trial. Br J Obstet Gynaecol 1999;106:1066-70.
34. World Health Organization. WHO recommendations for the
prevention and treatment of postpartum haemorrhage.
Geneva: World Health Organization, 2018.
35. Bateman BT, Huybrechts KF, Hernandez-Diaz S, Liu J,
Ecker JL, Avorn J. Methylergonovine maleate and the risk of
myocardial ischemia and infarction. Am J Obstet Gynecol
2013;209:459.e1-459.e13.
36. Mousa HA, Blum J, Abou El Senoun G, Shakur H, Alfirevic
Z. Treatment for primary postpartum haemorrhage. Cochrane
Database Syst Rev. 2014;2014:CD003249.
37. Blum J, Winikoff B, Raghavan S, et al. Treatment of post-partum
haemorrhage with sublingual misoprostol versus oxytocin in
women receiving prophylactic oxytocin: a double-blind,
randomised, non-inferiority trial. Lancet 2010;375:217-23.
38. Bilgin Z, Kömürcü N. Comparison of the effects and side
effects of misoprostol and oxytocin in the postpartum period:
a systematic review. Taiwan J Obstet Gynecol 2019;58:748-56.
39. Schmitz T, Tararbit K, Dupont C, et al. Prostaglandin E2
analogue sulprostone for treatment of atonic postpartum
hemorrhage. Obstet Gynecol 2011;118:257-65.
40. Zdanowicz JA, Utz AC, Bernasconi I, Geier S, Corti R, Beinder
E. «Broken heart» after cesarean delivery, case report and
review of literature. Arch Gynecol Obstet 2011;283:687-94.
desensitization of the oxytocin receptor. Am J
Obstet Gynecol 2003;188:497-502.
2. Phaneuf S, Asbóth G, Carrasco MP, et al. The desensitization
of oxytocin receptors in human myometrial cells is
accompanied by down-regulation of oxytocin receptor
messenger RNA. J Endocrinol 1997;154:7-18.
3. Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y,
Balki M. Oxytocin pretreatment decreases oxytocin-induced
myometrial contractions in pregnant rats in a concentrationdependent
but not time-dependent manner. Reprod Sci
2009;16:501-8.
4. Balki M, Cristian AL, Kingdom J, Carvalho JC. Oxytocin
pretreatment of pregnant rat myometrium reduces the
efficacy of oxytocin but not of ergonovine maleate or
prostaglandin F2α. Reprod Sci 2010;17:269-77.
5. Balki M, Erik-Soussi M, Kingdom J, Carvalho JC. Oxytocin
pretreatment attenuates oxytocin-induced contractions in
human myometrium in vitro. Anesthesiology 2013;119:552-61.
6. Balki M, Ramachandran N, Lee S, Talati C. The recovery time
of myometrial responsiveness after oxytocin-induced
desensitization in human myometrium in vitro. Anesth Analg
2016;122:1508-15.
7. Balki M, Erik-Soussi M, Ramachandran N, Kingdom J,
Carvalho JC. The contractile effects of oxytocin, ergonovine,
and carboprost and their combinations: an in vitro study on
human myometrial strips. Anesth Analg 2015;120:1074-84.
8. Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose
requirement after cesarean delivery for labor arrest. Obstet
Gynecol 2006;107:45-50.
9. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin
requirements at elective cesarean delivery: a dose-finding
study. Obstet Gynecol 2004;104:1005-10.
10. Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B.
Minimum effective bolus dose of oxytocin during elective
Caesarean delivery. Br J Anaesth 2010;104:338-43.
11. Lavoie A, McCarthy RJ, Wong CA. The ED90 of prophylactic
oxytocin infusion after delivery of the placenta during
cesarean delivery in laboring compared with nonlaboring
women: an up-down sequential allocation dose-response
study. Anesth Analg 2015;121:159-64.
12. Foley A, Gunter A, Nunes KJ, Shahul S, Scavone BM. Patients
undergoing cesarean delivery after exposure to oxytocin
during labor require higher postpartum oxytocin doses.
Anesth Analg 2018;126:920-4.
13. Drife J, Lewis G. Why mothers die, 1997-1999: The Fifth
Report of the Confidential Enquiries into Maternal Deaths in
the United Kingdom. London: Royal College of Obstetricians
and Gynecologists Press; 2001.
14. Dyer RA, Reed AR, van Dyk D, et al. Hemodynamic effects
of ephedrine, phenylephrine, and the coadministration of
phenylephrine with oxytocin during spinal anesthesia for
elective cesarean delivery. Anesthesiology 2009;111:753-65.
15. Rumboll CK, Dyer RA, Lombard CJ. The use of phenylephrine
to obtund oxytocin-induced hypotension and tachycardia during
caesarean section. Int J Obstet Anesth 2015;24:297-302.
16. Farber MK, Schultz R, Lugo L, Liu X, Huang C, Tsen LC. The
effect of co-administration of intravenous calcium chloride
and oxytocin on maternal hemodynamics and uterine tone
following cesarean delivery: a double-blinded, randomized,
placebo-controlled trial. Int J Obstet Anesth 2015;24:217-24.
17. Thomas JS, Koh SH, Cooper GM. Haemodynamic effects of
oxytocin given as i.v. bolus or infusion on women undergoing
caesarean section. Br J Anaesth 2007;98:116-9.
18. Jonsson M, Hanson U, Lidell C, Nordén-Lindeberg S. ST
depression at caesarean section and the relation to oxytocin
dose. A randomised controlled trial. Br J Obstet Gynaecol
2010;117:76-83.
19. Moran C, Ni Bhuinneain M, Geary M, Cunningham S,
McKenna P, Gardiner J. Myocardial ischaemia in normal
patients undergoing elective caesarean section: a peripartum
assessment. Anaesthesia 2001;56:1051-8.
20. Bergum D, Lonnée H, Hakli TF. Oxytocin infusion: acute
hyponatraemia, seizures and coma. Acta Anaesthesiol
Scand 2009;53:826-7.
21. Sartain JB, Barry JJ, Howat PW, McCormack DI, Bryant M.
Intravenous oxytocin bolus of 2 units is superior to 5 units
during elective caesarean section. Br J Anaesth 2008;101:
822-6.
22. Cole NM, Carvalho JC, Erik-Soussi M, Ramachandran N,
Balki M. In vitro comparative effect of carbetocin and
oxytocin in pregnant human myometrium with and without
oxytocin pretreatment. Anesthesiology 2016;124:378-86.
23. Su LL, Chong YS, Samuel M. Carbetocin for preventing
postpartum haemorrhage. Cochrane Database Syst Rev.
2012;2:CD005457.
24. Nguyen-Lu N, Carvalho JC, Farine D, Seaward G, Ye XY,
Balki M. Carbetocin at cesarean delivery for labour arrest:
a sequential allocation trial to determine the effective dose.
Can J Anaesth 2015;62:866-74.
25. Cordovani D, Balki M, Farine D, Seaward G, Carvalho JC.
Carbetocin at elective cesarean delivery: a randomized
controlled trial to determine the effective dose. Can J Anaesth
2012;59:751-7.
26. Khan M, Balki M, Ahmed I, Farine D, Seaward G, Carvalho
JC. Carbetocin at elective cesarean delivery: a sequential
allocation trial to determine the minimum effective dose. Can
J Anaesth 2014;61:242-8.
27. Anandakrishnan S, Balki M, Farine D, Seaward G, Carvalho
JC. Carbetocin at elective cesarean delivery: a randomized
controlled trial to determine the effective dose, part 2. Can
J Anaesth 2013;60:1054-60.
28. Tabl S, Balki M, Downey K, et al. Uterotonics in elective
caesarean delivery: a randomised non-inferiority study
comparing carbetocin 20 μg and 100 μg. Anaesthesia
2019;74:190-6.
29. Rosseland LA, Hauge TH, Grindheim G, Stubhaug A,
Langesæter E. Changes in blood pressure and cardiac
output during cesarean delivery: the effects of oxytocin and
carbetocin compared with placebo. Anesthesiology 2013;
119:541-51.
30. Moertl MG, Friedrich S, Kraschl J, Wadsack C, Lang U,
Schlembach D. Haemodynamic effects of carbetocin and
oxytocin given as intravenous bolus on women undergoing
caesarean delivery: a randomised trial. Br J Obstet Gynaecol
2011;118:1349-56.
31. Bateman BT, Berman MF, Riley LE, Leffert LR. The epidemiology
of postpartum hemorrhage in a large, nationwide sample of
deliveries. Anesth Analg 2010;110:1368-73.
32. Butwick AJ, Carvalho B, Blumenfeld YJ, El-Sayed YY, Nelson
LM, Bateman BT. Second-line uterotonics and the risk of
hemorrhage-related morbidity. Am J Obstet Gynecol
2015;212:642.e1-642.e6427.
33. Amant F, Spitz B, Timmerman D, Corremans A, Van Assche
FA. Misoprostol compared with methylergometrine for the
prevention of postpartum haemorrhage: a double-blind
randomised trial. Br J Obstet Gynaecol 1999;106:1066-70.
34. World Health Organization. WHO recommendations for the
prevention and treatment of postpartum haemorrhage.
Geneva: World Health Organization, 2018.
35. Bateman BT, Huybrechts KF, Hernandez-Diaz S, Liu J,
Ecker JL, Avorn J. Methylergonovine maleate and the risk of
myocardial ischemia and infarction. Am J Obstet Gynecol
2013;209:459.e1-459.e13.
36. Mousa HA, Blum J, Abou El Senoun G, Shakur H, Alfirevic
Z. Treatment for primary postpartum haemorrhage. Cochrane
Database Syst Rev. 2014;2014:CD003249.
37. Blum J, Winikoff B, Raghavan S, et al. Treatment of post-partum
haemorrhage with sublingual misoprostol versus oxytocin in
women receiving prophylactic oxytocin: a double-blind,
randomised, non-inferiority trial. Lancet 2010;375:217-23.
38. Bilgin Z, Kömürcü N. Comparison of the effects and side
effects of misoprostol and oxytocin in the postpartum period:
a systematic review. Taiwan J Obstet Gynecol 2019;58:748-56.
39. Schmitz T, Tararbit K, Dupont C, et al. Prostaglandin E2
analogue sulprostone for treatment of atonic postpartum
hemorrhage. Obstet Gynecol 2011;118:257-65.
40. Zdanowicz JA, Utz AC, Bernasconi I, Geier S, Corti R, Beinder
E. «Broken heart» after cesarean delivery, case report and
review of literature. Arch Gynecol Obstet 2011;283:687-94.