Oculocardiac Reflex during Anesthesia

Main Article Content

Patcharaon Sangjak
Papiroon Noitasaeng
Khanittha Vorasanon
Phongthara Vichitvejpaisal

Abstract

Oculocardiac reflex (OCR), a phenomenon that can occur during anesthesia, has been observed for more than a century. It can be triggered by pressure on the eyeball, manipulation of the extraocular muscles, or surgical manipulation of the eye or nearby structures. The reflex leads to a decrease in heart rate, which can cause significant hemodynamic changes, especially in patients with pre-existing cardiac disease. There are several strategies that can be employed to mitigate the OCR during anesthesia, including the use of local anesthesia, the administration of anticholinergic drugs, and the use of regional anesthesia techniques to avoid stimulation of the Trigeminal nerve. By understanding the mechanisms of the OCR and implementing appropriate interventions, anesthesiologists can help to minimize the risk of adverse events associated with this reflex during surgery.

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Review articles

References

Dunville LM, Sood G, Kramer J. Oculocardiac reflex. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2023 Apr 23]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499832/

American Academy of Ophthalmology. Oculocardiac reflex. [cited 2023 Apr 23]. Available from: https://eyewiki.aao.org/Oculocardiac_Reflex#Management

National Center for Biotechnology Information. How dose the nervous system work? [updated 2019 Aug 19; cited 2023 May 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279390/

Akinrodoye MA, Lui F. Neuroanatomy, somatic nervous system. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2023 May 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556027/

Pressbooks. The somatic nervous system. [cited 2023 May 21]. Available from: http://neuroscience.openetext.utoronto.ca/chapter/anatomy-

physiology-the-somatic-nervous-system/

Ken Hub. 12 Cranial nerves. [cited 2023 May 21]. Available from: https://www.kenhub.com/en/

library/anatomy/the-12-cranial-nerves

Waxenbaum JA, Reddy V, Varacallo M. Anatomy, autonomic nervous system. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2023 May 26]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539845/

Alshak MN, Das JM. Neuroanatomy, sympathetic nervous system. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 May 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542195/

Wisconsin technical college system. Autonomic nervous system basics. [cited 2023 May 21].

Available from: https://wtcs.pressbooks.pub/pharmacology/chapter/4-2-ans-basics/

Tindle J, Tadi P. Neuroanatomy, parasympathetic nervous system. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2023 May 26]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553141/.

Breit S, Kupferberg A, Rogler G, Hasler G. Vagus nerve as modulator of the brain-gut axis in

psychiatric and inflammatory disorders. Front Psychiatry. 2018;9:44.

Ludwig PE, Aslam S, Czyz CN. Anatomy, head and neck: eye muscles. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2023 Jun 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470534/.

Armstrong M, Kerndt CC, Moore RA. Physiology, baroreceptors. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 May 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538172/

Mizrak A, Erbagci I, Arici T, et al. Ketamine versus propofol for strabismus surgery in children. Clin Ophthalmol. 2010;4:673-9.

Arnold RW, Biggs RE, Beerle BJ. Intravenous dexmedetomidine augments the oculocardiac reflex. J AAPOS. 2018;22:211-3.e1.

Arnold RW, Jansen S, Seelig J, Glasionov M, Biggs RE, Beerle B. Anesthetic impacts on the oculocardiac reflex: evidence from a large, observational study. Clin Ophthalmol. 2021;15:973-81.

Biology dictionary. Valsalva maneuver. [cited 2023 May 21]. Available from: https://biologydictionary.net/valsalva-maneuver/

Qi Z, Zou F, Wu Y, et al. Effect of ice slush on reducing the oculocardiac reflex during strabismus surgery. Anesth Analg. 2023;136:79-85.

Weijuan Z, Zonghuan L, Qian W, Xizhi D, Bin J, Min K. Sub-Tenon’s bupivacaine injection is superior to placebo for pediatric strabismus surgery: a meta-analysis. Front Pediatr. 2023;11:1105186.

Yıldırım MY, Ülgey A, Talih G, Doğan H, Güneş I. Evaluation of the perioperative effects of dexmedetomidine and midazolam-ketamine premedication in strabismus surgery. J Pediatr Ophthalmol Strabismus. 2023;60:427-34.

Mizrak A, Erbagci I, Arici T, Avci N, Ganidagli S, Oner U. Dexmedetomidine use during strabismus

surgery in agitated children. Med Princ Pract. 2011;20:427-32.

Kartufan FF, Kizilcik N, Ziylan S, Menda F. Hydroxyzine dihydrochloride premedication is a necessity for pediatric patients undergoing strabismus surgery: an observational prospective clinical trial. J Ophthalmol. 2022;2022:4137144.

Karanovic N, Jukic M, Carev M, Kardum G, Dogas Z. Rocuronium attenuates oculocardiac reflex during squint surgery in children anesthetized with halothane and nitrous oxide. Acta Anaesthesiol Scand. 2004;48:1301-5.

Arnold RW, Jensen PA, Kovtoun TA, et al. The profound augmentation of the oculocardiac reflex by fast acting opioids. Binocul Vis Strabismus Q. 2004;19:215-22.

Zhu YL, Shen WH, Chen QR, et al. Desflurane anesthesia compared with total intravenous anesthesia on anesthesia-controlled operating room time in ambulatory surgery following strabotomy: a randomized controlled study. Chin Med J (Engl). 2020;133:779-85.

Ha SG, Huh J, Lee BR, Kim SH. Surgical factors affecting oculocardiac reflex during strabismus surgery. BMC Ophthalmol. 2018;18:103.