Intravenous Ketamine for Postoperative Pain Control in Spine Surgery: a Randomized Controlled Study
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Abstract
Introduction: Fast recovery after spinal surgery is a crucial goal to allow patients to perform daily activities and leave the hospital sooner. Patients undergoing spinal surgery often experience moderate to severe postoperative pain. Thus, the use of a multimodal analgesia may reduce pain, decrease morphine consumption, and diminish side effects. Methods: This study is a prospective randomized control trial conducted after receiving ethical approval. Patients undergoing spinal surgery were divided into two groups: group 1 received ketamine in addition to morphine, group 2 received only morphine during surgery, with 21 patients in each group. The study assessed the efficacy of ketamine in reducing morphine comsumption and pain scores up to 48 h after surgery. Additionally, the time to siting and ambulation after surgery, as well as the side effects from the pain medications were evaluated. Results: Pain scores in the recovery room, 24 and 48 h after surgery in the ketamine group were significantly lower than in the morphine group (P < 0.05). The morphine comsumption in the recovery room and 24 h after surgery in the ketamine group was significantly lower than in the morphine group (P < 0.05). The severe complications in both groups were none. In addition, the side effects were not significantly different between the two groups. Conclusion: Administration of ketamine during spinal surgery can reduce postoperative pain and decrease morphine consumpion without severe side effects.
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