Medication Adherence and Barriers Among Persons with Chronic Rhinosinusitis, the First Affiliated Hospital of Kunming Medical University

Authors

  • Qi Zhao Faculty of Nursing, Chiang Mai University
  • Achara Sukonthasarn School of Nursing, Panyapiwat Institute of Management
  • Suparat Wangsrikhun Faculty of Nursing, Chiang Mai University

Keywords:

Chronic rhinosinusitis, Medication adherence, Barriers to medication adherence

Abstract

Medication adherence is vital for controlling symptoms and preventing complications of chronic rhinosinusitis (CRS). The purpose of this descriptive study was to investigate medication adherence and barriers to medication adherence among persons with CRS. Purposive sampling was used to select 259 participants who were treated at the First Affiliated Hospital of Kunming Medical University, the People’s Republic of China. The research instruments included the demographic data form developed by the researchers, the 12-item Medication Adherence Scale (MAS) developed by Ueno et al., and the Adherence Barriers Questionnaire (ABQ) developed by Müller et al. The MAS and the ABQ were translated into Chinese by the researcher, and were tested for their reliability, yielding Cronbach’s alphas of 0.78 and 0.82, respectively.Descriptive statistics were used to analyze data.

The results revealed:
1. Participants had high medication adherence (M = 48.97, SD = 5.25); and
2. Intentional adherence barriers among the participants in this study included the belief that all medications were poisons (M = 3.33, SD = 0.75), being unsure of the need for medication (M = 3.26, SD = 0.68), and access to healthcare barriers (M = 3.15, SD = 0.66). Unintentional adherence barriers were feeling discouraged or depressed (M = 3.23, SD = 0.70), forgetfulness (M = 3.12, SD = 0.73), and not receiving required help (M = 2.59, SD = 0.94). Additionally, medication-related barriers included stopping or decreasing medications due to side effects (M = 3.23, SD = 0.59), being afraid of side effects (M = 3.22, SD = 0.66), and problems with taking medications (M = 3.19, SD = 0.68). A healthcare system barrier was participants’ co-payments (M = 3.25, SD = 0.69).

The results of this study provide valuable insights into medication adherence and its barriers among Chinese individuals with CRS. Healthcare providers can employ these findings to develop targeted strategies, such as education programs to address negative beliefs about medication, simplified medication schedules to combat forgetfulness, and financial assistance programs to reduce financial burden.

References

Agidew, E., Wale, M. Z., Kerebih, H., Yirsaw, M. T., Zewdie, T. H., Girma, M., & Miskir, A. (2021). Adherence to diabetes self-care management and associated factors among people with diabetes in Gamo Gofa Zone public health hospitals. SAGE Open Medicine, 9, 20503121211053953. https://doi.org/10.1177/20503121211053953

Awwad, O., Akour, A., Al-Muhaissen, S., & Morisky, D. (2015). The influence of patients' knowledge on adherence to their chronic medications: A cross-sectional study in Jordan. International Journal of Clinical Pharmacy, 37(3), 504-510. https://doi.org/10.1007/s11096-015-0086-3

Bala, M. M., Poklepovic Pericic, T., Zuljevic, M. F., Bralic, N., Zajac, J., Motaze, N. V., Rohwer, A., Gajdzica, M., & Young, T. (2024). Adherence to the guideline for reporting evidence-based practice educational interventions and teaching (GREET) of studies on evidence-based healthcare e-learning: A cross-sectional study. BMJ Evidence-Based Medicine, 29(4), 229-238. https://doi.org/10.1136/bmjebm-2023-112647

Benjamin, M. R., Stevens, W. W., Li, N., Bose, S., Grammer, L. C., Kern, R. C., Tan, B. K., Conley, D. B., Smith, S. S., Welch, K. C., Schleimer, R. P., & Peters, A. T. (2019). Clinical characteristics of patients with chronic rhinosinusitis without nasal polyps in an academic setting. Journal of Allergy and Clinical Immunology: In Practice, 7(3), 1010-1016. https://doi.org/10.1016/j.jaip.2018.10.014

Braun, D. L., Scheier, T., Ledermann, U., Flepp, M., Metzner, K. J., Boni, J., & Gunthard, H. F. (2020). Emergence of resistance to integrase strand transfer inhibitors during dolutegravir containing triple-therapy in a treatment-experienced patient with pre-existing M184V/I Mutation. Viruses, 12(11), 1330. https://doi.org/10.3390/v12111330

Chauke, G. D., Nakwafila, O., Chibi, B., Sartorius, B., & Mashamba-Thompson, T. (2022). Factors influencing poor medication adherence amongst patients with chronic disease in low-and-middle-income countries: A systematic scoping review. Heliyon, 8(6), e09716. https://doi.org/10.1016/j.heliyon.2022.e09716

Douglas, J. W., Lawrence, J. C., Turner, L. W., Knol, L. L., & Ellis, A. C. (2020). Practitioner knowledge, personal values, and work setting influence registered dietitians' feeding tube recommendations for patients with advanced dementia. Nutrition in Clinical Practice, 35(4), 634-641. https://doi.org/10.1002/ncp.10255

Eraso, Y., & Hills, S. (2021). Intentional and unintentional non-adherence to social distancing measures during COVID-19: A mixed-methods analysis. PLOS ONE, 16(8), e0256495. https://doi.org/10.1371/journal.pone.0256495

Fuhr, K., Schroder, J., Berger, T., Moritz, S., Meyer, B., Lutz, W., Hohagen, F., Hautzinger, M., & Klein, J. P. (2018). The association between adherence and outcome in an internet intervention for depression. Journal of Affective Disorders, 229, 443-449. https://doi.org/10.1016/j.jad.2017.12.028

Gutierrez, J. A., 3rd, Shannon, C. M., Chapurin, N., Schlosser, R. J., & Soler, Z. M. (2024). Challenges to medication adherence with intranasal corticosteroid irrigations. International Forum of Allergy & Rhinology, 14(1), 32-40. https://doi.org/10.1002/alr.23210

Hodges, J. R., Phillips, S. M., Norell, S., Nwosu, C., Khan, H., Luo, L., Badawy, S. M., King, A., Tanabe, P., Treadwell, M., Rojas Smith, L., Calhoun, C., Hankins, J. S., & Porter, J. (2020). Intentional and unintentional nonadherence to hydroxyurea among people with sickle cell disease: A qualitative study. Blood Advances, 4(18), 4463-4473. https://doi.org/10.1182/bloodadvances.2020001701

Jiang, M., Liao, L. Y., Liu, X. Q., He, W. Q., Guan, W. J., Chen, H., & Li, Y. M. (2015). Quality assessment of clinical practice guidelines for respiratory diseases in China: A systematic appraisal. Chest, 148(3), 759-766. https://doi.org/10.1378/chest.14-3201

Jose, P., Ravindranath, R., Joseph, L. M., Rhodes, E. C., Ganapathi, S., Harikrishnan, S., & Jeemon, P. (2021). Patient, caregiver, and health care provider perspectives on barriers and facilitators to heart failure care in Kerala, India: A qualitative study. Wellcome Open Research, 5, 250. https://doi.org/10.12688/wellcomeopenres.16365.2

Keating, M. K., Phillips, J. C., & Phillips, J. (2023). Chronic rhinosinusitis. American Family Physician, 108(4), 370-377. https://www.ncbi.nlm.nih.gov/pubmed/37843944

Konstantinou, P., Kassianos, A. P., Georgiou, G., Panayides, A., Papageorgiou, A., Almas, I., Wozniak, G., & Karekla, M. (2020). Barriers, facilitators, and interventions for medication adherence across chronic conditions with the highest non-adherence rates: A scoping review with recommendations for intervention development. Translational Behavioral Medicine, 10(6), 1390-1398. https://doi.org/10.1093/tbm/ibaa118

Kvarnstrom, K., Westerholm, A., Airaksinen, M., & Liira, H. (2021). Factors contributing to medication adherence in patients with a chronic condition: A scoping review of qualitative research. Pharmaceutics, 13(7), 1100. https://doi.org/10.3390/pharmaceutics13071100

Leland, E. M., Vohra, V., Seal, S. M., Zhang, Z., & Ramanathan, M., Jr. (2022). Environmental air pollution and chronic rhinosinusitis: A systematic review. Laryngoscope Investigative Otolaryngology, 7(2), 349-360. https://doi.org/10.1002/lio2.774

Liu, Z., Chen, J., Cheng, L., Li, H., Liu, S., Lou, H., Shi, J., Sun, Y., Wang, D., Wang, C., Wang, X., Wei, Y., Wen, W., Yang, P., Yang, Q., Zhang, G., Zhang, Y., Zhao, C., Zhu, D., … Zhang, L. (2020). Chinese society of allergy and Chinese society of otorhinolaryngology-head and neck surgery guideline for chronic rhinosinusitis. Allergy, Asthma and Immunology Research, 12(2), 176-237. https://doi.org/10.4168/aair.2020.12.2.176

Muller, S., Kohlmann, T., & Wilke, T. (2015). Validation of the adherence barriers questionnaire-an instrument for identifying potential risk factors associated with medication-related non-adherence. BMC Health Services Research, 15, 153. https://doi.org/10.1186/s12913-015-0809-0

Settineri, S., Frisone, F., Merlo, E. M., Geraci, D., & Martino, G. (2019). Compliance, adherence, concordance, empowerment, and self-management: Five words to manifest a relational maladjustment in diabetes. Journal of Multidisciplinary Healthcare, 12, 299-314. https://doi.org/10.2147/JMDH.S193752

Shen, S. A., Jafari, A., Qualliotine, J. R., & DeConde, A. S. (2020). Follow-up adherence is associated with outcomes after endoscopic sinus surgery. Annals of Otology, Rhinology & Laryngology, 129(7), 707-714. https://doi.org/10.1177/0003489420908291

Smith, K. A., & Alt, J. A. (2020). The relationship of chronic rhinosinusitis and depression. Current Opinion in Otolaryngology & Head and Neck Surgery, 28(1), 1-5. https://doi.org/10.1097/MOO.0000000000000595

Strickland, J. C., Stoops, W. W., Kincer, M. A., & Rush, C. R. (2019). The impact of financial strain on medication non-adherence: Influence of psychiatric medication use. Psychiatry Research, 271, 389-395. https://doi.org/10.1016/j.psychres.2018.11.055

Ueno, H., Yamazaki, Y., Yonekura, Y., Park, M. J., Ishikawa, H., & Kiuchi, T. (2018). Reliability and validity of a 12-item medication adherence scale for patients with chronic disease in Japan. BMC Health Services Research, 18(1), 592. https://doi.org/10.1186/s12913-018-3380-7

Wahid, N. W., Smith, R., Clark, A., Salam, M., & Philpott, C. M. (2020). The socioeconomic cost of chronic rhinosinusitis study. Rhinology, 58(2), 112-125. https://doi.org/10.4193/Rhin19.424

Xie, Z., Liu, K., Or, C., Chen, J., Yan, M., & Wang, H. (2020). An examination of the socio-demographic correlates of patient adherence to self-management behaviors and the mediating roles of health attitudes and self-efficacy among patients with coexisting type 2 diabetes and hypertension. BMC Public Health, 20(1), 1227. https://doi.org/10.1186/s12889-020-09274-4

Xu, J., Zhao, M., Vrosgou, A., Yu, N. C. W., Liu, C., Zhang, H., Ding, C., Roth, N. W., Pan, Y., Liu, L., Wang, Y., Wang, Y., & Bettger, J. P. (2021). Barriers to medication adherence in a rural-urban dual economy: A multi-stakeholder qualitative study. BMC Health Services Research, 21(1), 799. https://doi.org/10.1186/s12913-021-06789-3

Downloads

Published

2025-06-19

How to Cite

Zhao, Q., Sukonthasarn, A., & Wangsrikhun, S. (2025). Medication Adherence and Barriers Among Persons with Chronic Rhinosinusitis, the First Affiliated Hospital of Kunming Medical University. Nursing Journal CMU, 52(2), 14–30. retrieved from https://he02.tci-thaijo.org/index.php/cmunursing/article/view/267091

Issue

Section

RESEARCH  ARTICLES