Sarcopenia: A Silent Threat and Prevention from Adulthood to Older Age

Authors

  • Arunrat Utaisang Boromarajonani College of Nursing, Nakhon Phanom, Nakhon Phanom University
  • Benjayamas Pilayon Boromarajonani College of Nursing, Nakhon Phanom, Nakhon Phanom University

Keywords:

Mid-adulthood, Older adults, Prevention, Sarcopenia, Silent threat

Abstract

Sarcopenia is a condition characterized by a progressive loss of muscle mass and strength, leading to a decline in physical performance, increased frailty, a higher risk of falls, and reduced ability to perform daily activities. Although it is commonly regarded as a health problem among older adults, scientific evidence indicates that the degenerative process begins in mid-adulthood, with muscle mass decreasing by approximately 3–5% every decade. This condition is often described as a silent threat because it typically goes unrecognized in its early stages. Moreover, sarcopenia is closely associated with several chronic noncommunicable diseases, including type 2 diabetes, cardiovascular disease, and sarcopenic obesity, all of which significantly impact physical and mental health, quality of life, and healthcare expenditures.

Preventive and management strategies for sarcopenia should focus on comprehensive health promotion, emphasizing resistance exercise, adequate protein and vitamin D intake, and early screening beginning in adulthood to identify individuals at risk. Additionally, social and policy-level support such as community-based exercise programs, promotion of muscle health literacy, and integration of sarcopenia screening into primary healthcare services plays a crucial role in reducing the long-term burden of this condition.

This review aims to summarize current literature related to sarcopenia among middle-aged and older adults by exploring its underlying mechanisms, risk factors, and health, economic, and social impacts. It also presents evidence-based prevention and management approaches that can inform public health policy development and promote sustainable improvements in population health and quality of life.

References

Beaudart, C., Alcazar, J., Aprahamian, I., Batsis, J. A., Yamada, Y., Prado, C. M., Reginster, J. Y., Sanchez-Rodriguez, D., Lim, W. S., Sim, M., von Haehling, S., Woo, J., & Duque, G. (2025). Health outcomes of sarcopenia: A consensus report by the outcome working group of the Global Leadership Initiative in Sarcopenia (GLIS). Aging Clinical and Experimental Research, 37(1), 100. https://doi.org/10.1007/s40520-025-02995-9

Benz, E., Pinel, A., Guillet, C., Capel, F., Pereira, B., De Antonio, M., Pouget, M., Cruz-Jentoft, A. J., Eglseer, D., Topinkova, E., Barazzoni, R., Rivadeneira, F., Ikram, M. A., Steur, M., Voortman, T., Schoufour, J. D., Weijs, P. J. M., & Boirie, Y. (2024). Sarcopenia and sarcopenic obesity and mortality among older people. JAMA Network Open, 7(3), e243604. https://doi.org/10.1001/jamanetworkopen.2024.3604

Bhat, G., Ireland, A., Shah, N., Gondhalekar, K., Mandlik, R., Kajale, N., Katapally, T., Bhawra, J., Damle, R., & Khadilkar, A. (2024). Prevalence and factors associated with sarcopenia among urban and rural Indian adults in middle age: A cross-sectional study from Western India. PLOS Glob Public Health, 4(10), e0003553. https://doi.org/10.1371/journal.pgph.0003553

Chen, L. K., Woo, J., Assantachai, P., Auyeung, T. W., Chou, M. Y., Iijima, K., Jang, H. C., Kang, L., Kim, M., Kim, S., Kojima, T., Kuzuya, M., Lee, J. S. W., Lee, S. Y., Lee, W. J., Lee, Y., Liang, C. K., Lim, J. Y., Lim, W. S., ... Arai, H. (2020). Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. Journal of the American Medical Directors Association, 21(3), 300-307.e2. https://doi.org/10.1016/j.jamda.2019.12.012

Cruz-Jentoft, A. J., & Sayer, A. A. (2019). Sarcopenia. Lancet, 393(10191), 2636-2646. https://doi.org/10.1016/s0140-6736(19)31138-9

Ding, J., Yang, G., Sun, W., Li, Y., Wang, N., Wang, J., & Zhao, Y. (2024). Association of interleukin-6 with sarcopenia and its components in older adults: A systematic review and meta-analysis of cross-sectional studies. Annals of Medicine, 56(1), 2384664. https://doi.org/10.1080/07853890.2024.2384664

Duan, Z., Jiang, G., Zhu, Y., Huang, W., Huang, Y., & Yang, H. (2025). Association of possible sarcopenia and its components with all-cause mortality in a middle-aged and older population: A 9-year cohort study. Scientific Reports, 15(1), 30481. https://doi.org/10.1038/s41598-025-16034-0

Flor-Rufino, C., Barrachina-Igual, J., Pérez-Ros, P., Pablos-Monzó, A., & Martínez-Arnau, F. M. (2023). Resistance training of peripheral muscles benefits respiratory parameters in older women with sarcopenia: Randomized controlled trial. Archives of Gerontology and Geriatrics, 104, 104799. https://doi.org/10.1016/j.archger.2022.104799

Han, M., Woo, K., & Kim, K. (2024). Association of protein intake with sarcopenia and related indicators among Korean older adults: A systematic review and meta-analysis. Nutrients, 16(24), 4350. https://doi.org/10.3390/nu16244350

Huang, S., Zhou, F., Zhou, Y., Zhong, J., Hong, H., Weng, G., Wu, C., Liu, K., & Feng, W. (2025). Prevalence and influencing factors of sarcopenia among older adults in rural coastal areas of Ningbo City. Scientific Reports, 15, 6037. https://doi.org/10.1038/s41598-025-90017-z

Huang, W. F., Chen, Y. C., Chang, C. S., & Wu, C. H. (2025). Definition and diagnosis of sarcopenia: Asia-Pacific perspectives. Osteoporos and Sarcopenia, 11(2 Suppl), 2-10. https://doi.org/10.1016/j.afos.2025.05.004

Ispoglou, T., Norton, C., & McCullough, D. (2025). Editorial: Preventing sarcopenia and promoting musculoskeletal health in middle-aged adults: The role of exercise and nutrition. Frontiers in Sports and Active Living, 7, 1601326. https://doi.org/10.3389/fspor.2025.1601326

Jang, H., Kim, Y. H., & Min, J. (2022). Specific histamine regulating activity of surface-modified yeast vacuoles by histamine- binding protein and its immune-enhancing effect. Microbial Biotechnology, 15(10), 2645-2651. https://doi.org/10.1111/1751-7915.14116

Kim, D., Morikawa, S., Miyawaki, M., Nakagawa, T., Ogawa, S., & Kase, Y. (2025). Sarcopenia prevention in older adults: Effectiveness and limitations of non-pharmacological interventions. Osteoporos and Sarcopenia, 11(2 Suppl), 65-72. https://doi.org/10.1016/j.afos.2025.05.005

Kirk, B., Cawthon, P. M., Arai, H., Ávila-Funes, J. A., Barazzoni, R., Bhasin, S., Binder, E. F., Bruyere, O., Cederholm, T., Chen, L. K., Cooper, C., Duque, G., Fielding, R. A., Guralnik, J., Kiel, D. P., Landi, F., Reginster, J. Y., Sayer, A. A., Visser, M., … Global Leadership Initiative in Sarcopenia (GLIS) Group. (2024). The conceptual definition of sarcopenia: Delphi consensus from the global leadership initiative in Sarcopenia (GLIS). Age and Ageing, 53(3), afae052. https://doi.org/10.1093/ageing/afae052

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023). Inflammation and aging: Signaling pathways and intervention therapies. Signal Transduction and Targeted Therapy, 8(1), 239. https://doi.org/10.1038/s41392-023-01502-8

Luo, J., & Lee, R. Y. W. (2025). Physical activity reduces the incidence of sarcopenia in middle-aged adults. Ageing International, 50(1), 13. https://doi.org/10.1007/s12126-025-09590-3

Papadopoulou, S. K., Tsintavis, P., Potsaki, P., & Papandreou, D. (2020). Differences in the prevalence of sarcopenia in community-dwelling, nursing home and hospitalized individuals. A systematic review and meta-analysis. The Journal of Nutrition, Health & Aging, 24(1), 83-90. https://doi.org/10.1007/s12603-019-1267-x

Sathyakumar, S. (2025). Type 2 Diabetes and sarcopenia. Apollo Medicine, 22(3), 249-256. https://doi.org/10.1177/09760016251326660

Sha, T., Zhang, Y., Joshi, A. D., Lane, N. E., Wei, J., Li, W., Xie, H., Li, J., Li, C., Zeng, C., Lei, G., & Wang, Y. (2025). Smoking, alcohol and risk of sarcopenia: A Mendelian randomisation study. BMJ Open, 15(4), e091656. https://doi.org/10.1136/bmjopen-2024-091656

Shi, Y., Tang, Y., Stanmore, E., McGarrigle, L., & Todd, C. (2023). Non-pharmacological interventions for community-dwelling older adults with possible sarcopenia or sarcopenia: A scoping review. Archives of Gerontology and Geriatrics, 112, 105022. https://doi.org/10.1016/j.archger.2023.105022

Somboontanont, W., & Thiengtham, S. (2025). Role of community nurses in sarcopenia screening and prevention for community-dwelling older adults. Journal of Public Health Nurses, 39(1), 93-113. https://he01.tci-thaijo.org/index.php/phn/article/view/277022/186919 (in Thai)

Vanitcharoenkul, E., Unnanuntana, A., Chotiyarnwong, P., Laohaprasitiporn, P., Adulkasem, N., Asavamongkolkul, A., & Chandhanayingyong, C. (2024). Sarcopenia in Thai community-dwelling older adults: A national, cross-sectional, epidemiological study of prevalence and risk factors. BMC Public Health, 24, 311. https://doi.org/10.1186/s12889-024-17804-7

Wei, W. X., Mao, Z. F., Chen, M. L., & Meng, L. (2025). The impact of chronic diseases and lifestyle on sarcopenia risk in older adults: A population-based longitudinal study. Frontiers in Medicine, 12, 1500915. https://doi.org/10.3389/fmed.2025.1500915

World Health Organization. (2020). WHO Guidelines on physical activity and sedentary behaviour. https://iris.who.int/server/api/core/bitstreams/faa83413-d89e-4be9-bb01-b24671aef7ca/content

Zhang, N., Zhai, L., Wong, R. M. Y., Cui, C., Law, S. W., Chow, S. K. H., Goodman, S. B., & Cheung, W. H. (2024). Harnessing immunomodulation to combat sarcopenia: Current insights and possible approaches. Immunity & Ageing, 21(1), 55. https://doi.org/10.1186/s12979-024-00458-9

Zhao, X., Liu, D., Zhang, H., Shen, S., Zhang, N., Pan, Y., Fu, C., Wang, W., Ren, H., & Pan, X. (2024). Associations of physical activity intensity, frequency, duration, and volume with the incidence of sarcopenia in middle-aged and older adults: A 4-year longitudinal study in China. BMC Geriatrics, 24(1), 258. https://doi.org/10.1186/s12877-024-04873-x

Downloads

Published

2026-06-30

How to Cite

Utaisang, A., & Pilayon, B. (2026). Sarcopenia: A Silent Threat and Prevention from Adulthood to Older Age. Nursing Journal CMU, 53(2), 239–251. retrieved from https://he02.tci-thaijo.org/index.php/cmunursing/article/view/277600

Issue

Section

ACADEMIC  ARTICLES