Integrated Meta-Analysis: Global Strategies for Promoting Rational Drug Use and Driving Modern Health Policy
Keywords:
Rational Drug Use, Meta-Analysis, Promotional Measures, Effectiveness, Success FactorsAbstract
This meta-analysis aimed to assess the current global situation of rational drug use, analyze the effectiveness of various measures promoting rational drug use, and identify factors influencing the success or failure of these measures. The study included 147 relevant research articles published between 2020 and 2024, searched from PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus databases using selection criteria focused on studies evaluating rational drug use promotion measures in various healthcare settings. The analysis employed meta-analysis and meta-regression techniques.
The results revealed differences in rational drug use rates across regions and country income levels, with high-income countries demonstrating higher rates compared to middle- and low-income countries. The most effective measure was the combined approach (Pooled Effect Size = 0.89, 95% CI: 0.82-0.96), followed by the use of decision support technologies (Pooled Effect Size = 0.81, 95% CI: 0.73-0.89). Factors contributing to success included intervention intensity, follow-up duration, stakeholder involvement, and integration with existing health systems. These findings highlight the need for developing context-specific approaches, particularly in low- and middle-income countries.
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