Sensitivity and Specificity of Immature Granulocyte Count for Diagnosis of Neonatal Sepsis at Prapokklao Hospital
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Abstract
Background: Neonatal sepsis is a significant cause of morbidity and mortality in neonates. It is difficult to establish a diagnosis of neonatal sepsis. The gold standard for establishing sepsis is by microbiology method. Thus, using hematology parameters like immature granulocytes can be used as markers to diagnose sepsis more efficiently, faster and cost-effectively.
Objectives: To study the sensitivity and specificity of immature granulocytes in the diagnosis of neonatal sepsis at Prapokklao Hospital.
Materials and methods: This was an analytic cross-sectional study of neonatal sepsis at Prapokklao Hospital. Data was collected by using data records forms and inpatient data from Prapokklao Hospital between February 1st and September 30th 2018.
Results: Two hundred and ninety-five newborn patients were enrolled. 120 patients were preterm newborns, while 175 patients were term newborns. Total positive blood culture were 17 patients (5.7%). Sensitivity and specificity of %IG for diagnosis of neonatal sepsis was 37.5% and 68.9%, respectively. There was no statistical difference between immature granulocyte percentage of hemoculture-positive and hemoculture-negative suspected neonatal sepsis patients.
Conclusion: Immature granulocyte percentage cannot predict positive hemoculture in patients with suspected neonatal sepsis. Further studies must be done to explore alternative ways to help in the diagnosis of this condition.
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References
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