Effect of COVID Vaccination on Reducing Chest Radiographic Severity Score in COVID-19 Patients at Bangbo Hospital, Samutprakan Province
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Abstract
BACKGROUND: COVID-19 vaccines remain effective against severe disease despite limited protection against infection caused by SARS-CoV-2 variants.
OBJECTIVES: To assess the effect of vaccination status on imaging severity in patients with COVID-19 through chest radiographs.
METHODS: In this retrospective study, COVID-19-confirmed patients between the ages of 18 and 59 years with no significant comorbidity who were admitted to Bangbo Hospital from September 1 to December 31, 2021 were identified. Each patient’s chest radiograph was examined to determine the extent of their lung involvement using the Modified Brixia Score. Patients were classified into three groups based on their vaccination status: fully vaccinated, partially vaccinated, and unvaccinated. Differences in Modified Brixia Scores between the groups according to vaccination status were analyzed using the Kruskal-Wallis test.
RESULTS: The study included 161 patients; the mean age was 37.8 years and 88 (54.7%) were women; 58 patients (36.0%) were fully vaccinated, 33 (20.5%) were partially vaccinated, and 70 (43.5%) were unvaccinated. The Modified Brixia Score of the unvaccinated patients (4.7±5.7) was significantly higher compared to those of partially (1.6±4.0) and fully vaccinated patients (1.1±3.1).
CONCLUSIONS: COVID-19 vaccines resulted in a significant reduction in the severity score seen on chest radiographs. Partially and fully vaccinated patients had a lower Modified Brixia Score compared to unvaccinated patients.
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References
Zeng B, Gao L, Zhou Q, Yu K, Sun F. Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis. BMC Med [Internet]. 2022 [cited 2023 Dec 7];20(1):200. Available from: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02397-y
Department of Disease Control, Ministry of Public Health. Daily COVID-19 vaccination situation [Internet].2022 [cited 2022 Dec 7]. Available from: https://ddc.moph.go.th/vaccine-covid19/diaryReport
Vannako P, SunongbuaA. Associations between COVID-19 vaccine and severityof COVID-19, Chaiyaphum hospital: 2021-2022. Regional Health Promotion Center 9 Journal 2022;16: 1057-69.
Manna S, Wruble J, Maron SZ, Toussie D, Voutsinas N, Finkelstein M, et al. COVID-19: A multimodality review of radiologic techniques, clinical utility, and imaging features. Radiol Cardiothorac Imaging [Internet]. 2020 [cited 2022 Dec 7];2(3):e200210. Available from: http://dx.doi.org/10.1148/ryct.2020200210
Wasilewski PG, Mruk B, Mazur S, Półtorak-Szymczak G, Sklinda K, Walecki J. COVID-19 severity scoring systems in radiological imaging-a review. Pol J Radiol [Internet]. 2020;[cited 2023 Feb 27];85:e361–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425223/
Borghesi A, Zigliani A, Golemi S, Carapella N, Maculotti P, Farina D, et al. Chest X-ray severity index as a predictor of in-hospital mortality in coronavirus disease 2019: A study of 302 patients from Italy. Int J Infect Dis 2020;96:291–3.
Wong HYF, Lam HYS, Fong AH-T, Leung ST, Chin TW-Y, Lo CSY, et al. Frequency and distribution of chest radiographic findings in patients positive for COVID-19. Radiology 2020;296:E72–8.
Hanley M, Brosnan C, O’Neill D, Ni Mhuircheartaigh N, Logan M, Morrin MM, et al. Modified Brixia chest X-ray severity scoring system and correlation with intubation, non-invasive ventilation and death in a hospitalised COVID-19 cohort. J Med Imaging Radiat Oncol 2021; 66:761-7.
Toussie D, Voutsinas N, Finkelstein M, Cedillo MA, Manna S, Maron SZ, et al. Clinical and chest radiography features determine patient outcomes in young and middle-aged adults with COVID-19. Radiology [Internet]. 2020[cited 2023 Feb 27];297:E197–206. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507999/
Ratnarathon A. Clinical characteristics and chest radiographic findings of coronavirus disease 2019 (COVID-19). Dis Control J 2020;46:540-50.
Borghesi A, Maroldi R. Vaccination and reduced severity of COVID-19 pneumonia viewed at chest radiography. Radiology [Internet]. 2022[cited 2023 Feb 27];304(3):E47. Available from: http://dx.doi.org/10.1148/radiol.220309
Larici AR, Cicchetti G, Marano R, Bonomo L, Storto ML. COVID-19 pneumonia: current evidence of chest imaging features, evolution and prognosis. Chin J Acad Radiol 2021; 4:229–40.
Modi SD, Shah DH, Mundhra KS, Gandhi B, Shah R, Kagathara V, et al. Comparative study of CT severity index and outcome in hospitalised vaccinated and non vaccinated patients of covid 19 pneumonia. J Radiol Clin Imaging 2021;04:93-101.
Lakhia RT, Trivedi JR. The CT scan lung severity score and vaccination status in COVID-19 patients in India: Perspective of an independent radiology practice. medRxiv [Internet]. 2021 [cited 2022 Dec 7] . Available from: http://dx.doi.org/10.1101/2021.07.15.21260597
Abo-Hedibah SA, Tharwat N, Elmokadem AH. Is chest X-ray severity scoring for COVID-19 pneumonia reliable? Pol J Radiol [Internet]. 2021[cited 2023 Feb 5];86:e432–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369822/
Borakati A, Perera A, Johnson J, Sood T. Diagnostic accuracy of X-ray versus CT in COVID-19: a propensity-matched database study. BMJ Open [Internet]. 2020 [cited 2023 Feb 5]; 10(11):e042946. Available from: https://dx.doi.org/10.1136/bmjopen-2020-042946