A Comparison of Operative Time, Intra-Operative and Post-Operative Complications and Hospital Stay between LigaSure with Clamp and Tie Method plus Electrocautery in Patients Undergoing Hemithyroidectomy: A Randomized, Single-blinded Study
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Abstract
BACKGROUND: An operation for a unilateral thyroidectomy that involves clamping, cutting, tying and electrocautery (old methods) takes a significant amount of time and can be dangerous to the laryngeal nerve. Consequently, LigaSure is used for unilateral thyroidectomy as it has been found to potentially reduce the duration of surgery as well as minimize the amount of bleeding and damage to the laryngeal nerve.
OBJECTIVE: To compare the duration of surgery concerning intra- and post-operative complications and length of hospital stay between the use of LigaSure and conventional methods involving clamping, cutting, tying and electrocauterization for unilateral thyroidectomy.
METHODS: A randomized controlled trial was conducted involving 16 patients who were randomly assigned into 2 groups with 8 patients in each, namely the LigaSure (L) group and conventional methods (C) group. Duration of surgery, amount of bleeding during and after surgery, paralysis of the vocal cords, post-operative hypothyroidism and length of hospital stay were recorded between 3 April 2020 and 28 February 2022 by using statistics, analysis and comparison of continuous data with the Mann-Whitney U-test, and analysis for comparison of discrete data with Chi-square test or Fisher’s exact test.
RESULTS: The median operative times for groups L and C were 65.0 and 97.5 minutes, respectively (p=0.006). The difference between post-operative hypothyroidism (a secondary objective) and length of hospital stay was not statistically significant, and no vocal cord paralysis was observed.
CONCLUSION: The LigaSure instrument significantly shortened the time required for unilateral thyroidectomy compared with clamping, cutting, tying and electrocautery methods.
Thaiclinicaltrials.org number, TCTR20220225001
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