Perianal Mucinous Adenocarcinoma associated with a Long Standing Fistula in Ano: Report of a Case and Review of the Literature

Authors

  • Pitichote Hiranyatheb Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Chakrapan Euanorasetr Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Weerapa Suwanthanma Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Panus Chalermsanyakorn Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Bordin Natawas Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Warapat Virayavanich Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Keywords:

Perianal Mucinous Adenocarcinoma, Perianal abscess

Abstract

Perianal mucinous adenocarcinoma presented with chronic perianal abscess is a rare disease. Early diagnosis is difficult and need a high index of suspicion and adequate biopsy. Most surgical option for operable cases is abdominoperineal resection. There are still no standard regimen for pre-or post operative chemoradiation treatment. Here, we report a case of this that was previously presented with a long-standing fistula in ano and a review of the literature on this rare disease.

References

Gaertner WB, Hagerman GF, Finne CO, Alavi K, Jessurun J, Rothenberger DA, et al. Fistula-associated anal adenocarcinoma: good results with aggressive therapy. Dis Colon Rectum. 2008;51(7):1061-7. doi:10.1007/s10350-008-9294-4.

Johnson LG, Madeleine MM, Newcomer LM, Schwartz SM, Daling JR. Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973-2000. Cancer. 200415;101(2):281-8. doi:10.1002/cncr.20364.

Okada K, Shatari T, Sasaki T, Tamada T, Suwa T, Furuuchi T, et al. Is histopathological evidence really essential for making a surgical decision about mucinous carcinoma arising in a perianal fistula? Report of a case. Surg Today. 2008;38(6):555-8. doi:10.1007/s00595-007-3651-0. doi:10.1007/s00595-007-3651-0.

Fenger C, Frisch M, Marti MC. Parc R. Chapter 7: Tumours of the Anal Canal. In: Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Digestive System.3rd ed. Lyon: IARC Press; 2000:146-55. https://www.patologi.com/who%20mage.pdf.

Rosser C. The relation of fistula in ano to cancer of the anal canal. Trans Am Proct Soc. 1934;35:65-71.

Sato H, Maeda K, Maruta M, Kuroda M, Nogaki M, Nogaki M. Mucinous adenocarcinoma associated with chronic anal fistula reconstructed by gracilis myocutaneous flaps. Tech Coloproctol. 2006;10(3):249-52. doi:10.1007/s10151-006-0289-7.

Schwartz A. Anorectal Fistula and Cancer. Dis Colon Rectum. 1963;6:305-7. doi:10.1007/bf02617271.

Schaffzin DM, Stahl TJ, Smith LE. Perianal mucinous adenocarcinoma: unusual case presentations and review of the literature. Am Surg. 2003;69(2):166-9.

Jones EA, Morson BC. Mucinous adenocarcinoma in anorectal fistulae. Histopathology. 1984;8(2):279-92. doi:10.1111/j.1365-2559.1984.tb02342.x.

Taniguchi S1, Yamanari H, Inada K, Iwamura T, Hokkoku S, Tanaka S, et al. Adenocarcinoma in the anal canal associated with a fistula: report of a case. Surg Today. 1996;26(9):707-10. doi:10.1007/bf00312089.

Getz SB Jr, Ough YD, Patterson RB, Kovalcik PJ. Mucinous adenocarcinoma developing in chronic anal fistula: report of two cases and review of the literature. Dis Colon Rectum. 1981;24(7):562-6. doi:10.1007/bf02604325.

Church JM, Weakley FL, Fazio VW, Sebek BA, Achkar E, Carwell M. The relationship between fistulas in Crohn's disease and associated carcinoma. Report of four cases and review of the literature. Dis Colon Rectum. 1985;28(5):361-6. doi:10.1007/bf02560444.

Yang BL, Shao WJ, Sun GD, Chen YQ, Huang JC. Perianal mucinous adenocarcinoma arising from chronic anorectal fistulae: a review from single institution. Int J Colorectal Dis. 2009;24(9):1001-6. doi:10.1007/s00384-009-0657-7.

Ky A, Sohn N, Weinstein MA, Korelitz BI. Carcinoma arising in anorectal fistulas of Crohn's disease. Dis Colon Rectum. 1998;41(8):992-6. doi:10.1007/bf02237388.

Papapolychroniadis C, Kaimakis D, Giannoulis K, Berovalis P, Karamanlis E, Haritanti A, et al. A case of mucinous adenocarcinoma arising in long-standing multiple perianal and presacral fistulas. Tech Coloproctol. 2004;8 Suppl 1:s138-40. doi:10.1007/s10151-004-0136-7.

Venclauskas L, Saladzinskas Z, Tamelis A, Pranys D, Pavalkis D. Mucinous adenocarcinoma arising in an anorectal fistula. Medicina (Kaunas). 2009;45(4):286-90.

Ong J, Jit-Fong L, Ming-Hian K, Boon-Swee O, Kok-Sun H, Eu KW. Perianal mucinous adenocarcinoma arising from chronic anorectal fistulae: a review from a single institution. Tech Coloproctol. 2007;11(1):34-8. doi:10.1007/s10151-007-0322-5.

Sierra EM, Villanueva Saenz E, Martínez PH, Rocha JR. Mucinous adenocarcinoma associated with fistula in ano: report of a case. Tech Coloproctol. 2006;10(1):51-3. doi:10.1007/s10151-006-0251-8.

Erhan Y, Sakarya A, Aydede H, Demir A, Seyhan A, Atici E. A case of large mucinous adenocarcinoma arising in a long-standing fistula-in-ano. Dig Surg. 2003;20(1):69-71. doi:10.1159/000068857.

Anthony T, Simmang C, Lee EL, Turnage RH. Perianal mucinous adenocarcinoma. J Surg Oncol. 1997;64(3):218-21. doi:10.1002/(sici)1096-9098(199703)64:3<218::aid-jso8>3.0.co;2-d.

Yamaguchi T, Kagawa R, Takahashi H, Takeda R, Sakata S, Nishizaki D. Diagnostic implications of MR imaging for mucinous adenocarcinoma arising from fistula in ano. Tech Coloproctol. 2009;13(3):251-3. doi:10.1007/s10151-009-0509-z.

Welch GH, Finlay IG. Neoplastic transformation in longstanding fistula-in-ano. Postgrad Med J. 1987;63(740):503-4. doi:10.1136/pgmj.63.740.503.

Leal RF, Ayrizono ML, Coy CS, Fagundes JJ, Góes JR. Mucinous adenocarcinoma derived from chronic perianal fistulas: report of a case and review of the literature. Tech Coloproctol. 2007;11(2):155-7. doi:10.1007/s10151-007-0348-8.

Hama Y, Makita K, Yamana T, Dodanuki K. Mucinous adenocarcinoma arising from fistula in ano: MRI findings. AJR Am J Roentgenol. 2006;187(2):517-21. doi:10.2214/AJR.05.0011.

Hussain SM, Outwater EK, Siegelman ES. Mucinous versus nonmucinous rectal carcinomas: differentiation with MR imaging. Radiology. 1999;213(1):79-85. doi:10.1148/radiology.213.1.r99se3879.

Fujimoto H, Ikeda M, Shimofusa R, Terauchi M, Eguchi M. Mucinous adenocarcinoma arising from fistula-in-ano: findings on MRI. Eur Radiol. 2003;13(8):2053-4. doi:10.1007/s00330-002-1798-z.

Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 2000;13(9):962-72. doi:10.1038/modpathol.3880175.

Klas JV, Rothenberger DA, Wong WD, Madoff RD. Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes. Cancer. 1999;85(8):1686-93. doi:10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7.

Downloads

Published

2011-09-26

How to Cite

1.
Hiranyatheb P, Euanorasetr C, Suwanthanma W, Chalermsanyakorn P, Natawas B, Virayavanich W. Perianal Mucinous Adenocarcinoma associated with a Long Standing Fistula in Ano: Report of a Case and Review of the Literature. Rama Med J [Internet]. 2011 Sep. 26 [cited 2024 Dec. 22];34(3):167-74. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/137866

Issue

Vol. 34 No. 3 (2011): July-September

Section

Case Reports