Fulminant Aspergillus Pneumonitis in a Healthy Child with Chronic Granulomatous Disease
Keywords:
Chronic granulomatous disease, AspergillusAbstract
Chronic granulomatous disease (CGD) is an inherited immunodeficiency characterized as defect in one of the 4 subunits of the nicotinamide adenine dinucleotide phosphate oxidase complex affecting phagocytosis activities. Patients] symptoms are usually gradual onset or asymptomatic. The authors report a girl with rapidly progressive pneumonia in previously healthy child who not response empirical antibiotic.
References
Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(3):327-60. doi:10.1086/525258.
Greene RE, Schlamm HT, Oestmann JW, Stark P, Durand C, Lortholary O, et al. Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign. Clin Infect Dis. 2007;44(3):373-9. doi:10.1086/509917.
Thomas KE, Owens CM, Veys PA, Novelli V, Costoli V. The radiological spectrum of invasive aspergillosis in children: a 10-year review. Pediatr Radiol. 2003;33(7):453-60. doi:10.1007/s00247-003-0919-4.
Cornillet A, Camus C, Nimubona S, Gandemer V, Tattevin P, Belleguic C, et al. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis. 2006;43(5):577-84. doi:10.1086/505870.
Antachopoulos C, Walsh TJ, Roilides E. Fungal infections in primary immunodeficiencies. Eur J Pediatr. 2007;166(11):1099-117. doi:10.1007/s00431-007-0527-7.
Gupta A, McKean M, Haynes S, Wright C, Barge D, Flood TJ, et al. Chronic granulomatous disease presenting as fulminant Aspergillus pneumonitis: a lethal combination? Pediatr Crit Care Med. 2009;10(4):e43-5. doi:10.1097/PCC.0b013e318198b22a.
Segal BH, DeCarlo ES, Kwon-Chung KJ, Malech HL, Gallin JI, Holland SM. Aspergillus nidulans infection in chronic granulomatous disease. Medicine (Baltimore). 1998;77(5):345-54. doi:10.1097/00005792-199809000-00004.
Winkelstein JA, Marino MC, Johnston RB Jr, Boyle J, Curnutte J, Gallin JI, et al. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore). 2000;79(3):155-69. doi:10.1097/00005792-200005000-00003.
Almyroudis NG, Holland SM, Segal BH. Invasive aspergillosis in primary immunodeficiencies. Med Mycol. 2005;43 Suppl 1:S247-59. doi:10.1080/13693780400025203.
Jirapongsananuruk O, Malech HL, Kuhns DB, Niemela JE, Brown MR, Anderson-Cohen M, et al. Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay. J Allergy Clin Immunol. 2003;111(2):374-9. doi:10.1067/mai.2003.58.
Steinbach WJ. Invasive aspergillosis in pediatric patients. Curr Med Res Opin. 2010;26(7):1779-87. doi:10.1185/03007995.2010.487793.
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