Prevalences of Abnormal Maternal TPO-Antibodies and TSH Levels of Thai Pregnant Women in Ramathibodi Hospital

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Kim Wongcharoenrat
Suwanee Janumpakul
Karan Paisooksantivatana
Boonsri Chanrachakul
Kalayanee Khupulsup


Background: Abnormal maternal thyroid function during pregnancy is associated with adverse affect to the maternal health and child development. Elevated serum thyroid stimulating hormone (TSH) in pregnant women is associated with impaired neuropsychiatric development of the child. Presence of thyroid peroxidase antibodies (TPO-Ab) is a significant risk factor for maternal postpartum thyroid disease.

Objective: This study was to determine prevalences of abnormal TSH and TPO-Ab in Thai pregnancies.

Method: Serum sample were obtained from 480 pregnant women as a part of their routine antenatal screening at Ramathibodi Hospital during August and October 2008. Measurement of TSH and TPO-Ab was done using Chemiluminescent Microparticle Immunoassay.

Results: The prevalences of abnormal TSH and TPO-Ab in Thai pregnancies were 9.79% and 13.96%, respectively. The highest frequency was found in 30.34 year-old age group. TSH abnormality was significantly associated with gestational age (P = 0.037). Abnormal TSH levels were mostly in first trimester of pregnancies.

Conclusion: Since abnormal thyroid function is common in Thai pregnancies, maternal screening of TSH and TPO-Ab should be considered.

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How to Cite
Wongcharoenrat, K., Janumpakul, S., Paisooksantivatana, K. ., Chanrachakul, B., & Khupulsup, K. (2010). Prevalences of Abnormal Maternal TPO-Antibodies and TSH Levels of Thai Pregnant Women in Ramathibodi Hospital. Ramathibodi Medical Journal, 33(1), 19–25. Retrieved from
Original Articles


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