Can Adiponectin Predict Hypertensive Disorder in Pregnancy?

Authors

  • Somsri Pitukkijronnakorn Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Panyu Panburana Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Kanokwan Wetsatada Department of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Umaporn Udomsubpayakul Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Sawaek Weerakiet Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Keywords:

Adiponectin, Hypertensive disorder in pregnancy, Preeclampsia, Insulin resistance, Hypertension, Pregnancy

Abstract

Objective: To determine whether adiponectin can predict hypertensive disorder in pregnancy (HDP).

Methods: All women with singleton pregnancy and who were at risk of gestational diabetes mellitus (GDM) were studied. They underwent a 50 gram glucose challenge test (GCT) and a blood sample test for adiponectin between 21 and 27 weeks gestation. Subsequently, between 24 and 28 weeks gestation the women underwent a 100 gram oral glucose tolerance test (OGTT). The pregnancy and perinatal outcomes in all women were observed and analyzed.

Results: There were 359 women enrolled in this study. Twenty-two case of HDP (6.1%) and 60 women with GDM (16.7%) were diagnosed. There were no significant difference in age, pre-pregnant BMI, sampling day BMI, weight gain on sampling day and total weight gain during pregnancy in both groups. Serum adiponectin was not significantly lower in HDP than non-HDP women (P = NS). There was a relationship between pre-pregnant BMI and total adiponectin levels in HDP (P = 0.0143). The area under the receiver-operator characteristic curve was 0.5853. In order to predict HDP, an arbitrarily cut-off value of adiponectin was determined. With the adiponectin cut-off value < 4.4 mg/ml, the sensitivity, specificity, PPV and NPV were 4.55%, 90.50%, 4.76% and 93.14% respectively. At cut-off value, only 1 out of 22 cases of HDP could be identified.

Conclusion: The levels of adiponectin in women with HDP were not significantly different from those without HDP and could not predict HDP.

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Published

2010-06-25

How to Cite

1.
Pitukkijronnakorn S, Panburana P, Wetsatada K, Udomsubpayakul U, Weerakiet S. Can Adiponectin Predict Hypertensive Disorder in Pregnancy?. Rama Med J [Internet]. 2010 Jun. 25 [cited 2024 Dec. 22];33(2):49-56. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/138362

Issue

Vol. 33 No. 2 (2010): April-June

Section

Original Articles