Symptom Clusters in Thai Gynecological Oncology Patients Receiving the First Cycle of Carboplatin and Paclitaxel

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Bualuang Sumdaengrit
Suteera Chukkul Luengsukcharoen
Sirapiechchaya Patharathamaporn


Background: Gynecological oncology patients have been suffering from cancer and a set of symptom cluster from treatment. To pass the suffering from the first cycle of chemotherapy is meant that patients can pass all the left five cycles of them.  Purposes of this study were to examine (1) symptom occurrence and severity after chemotherapy day 1 to 14 and (2) the change of symptom cluster occurrences in Thai gynecologic oncology patients receiving first cycle of Carboplatin and Paclitaxel at day 1. 3,7, and 14.

Methods: This is descriptive study One hundred and ten women were recruited from gynecologic oncology department in a hospital affiliated university. The National Cancer Institute Symptom Severity Diary and the Demographic, Disease, and Treatment Questionnaires were used to collected data.  The National Cancer Institute Symptom Severity Diary was recorded from the 1st day to 14th day after first cycle of chemotherapy. Factor analysis was used for analyzing data.

Results: Results reported top five most symptom occurrences were fatigue, numbness, anorexia, pain, and constipation. Top 5 most symptom severity were pain, numbness, fatigue, anorexia, and alopecia. These symptom were changed from day 1-14 after receiving first cycle of Carboplatin and Paclitaxel. There were 2 clusters of symptom occurrence at day 1 after receiving chemotherapy were neuropathy side effects and gastro – intestinal effects. At day 3, there were gastro – intestinal effects and sleep pattern change. At day 7, there were gastro – intestinal effects; neuropathy side effects; and sleep pattern change. Lastly, at day14, there were gastro – intestinal effects and neuropathy side effects.

Conclusions: Findings provided an evidenced data for side effects’ management appropriate with context in gynecological oncology patients receiving the first cycle of Carboplatin and Paclitaxel.


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Sumdaengrit, B., Chukkul Luengsukcharoen, S., & Patharathamaporn, S. (2016). Symptom Clusters in Thai Gynecological Oncology Patients Receiving the First Cycle of Carboplatin and Paclitaxel. Ramathibodi Medical Journal, 39(2), 90–99. Retrieved from
Original Articles


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