Outcome of Living Donor Hepatectomy for Pediatric Liver Transplantation: Report of 100 Cases at Ramathibodi Hospital

Authors

  • Nuttapon Arpornsujaritkun Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Surasak Leelaudomlipi Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Abhasnee Sobhonslidsuk Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Somkit Mingphruedhi Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Sutipong Jongjirasiri Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Pongphob Intaraprasong Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Panuwat Lertsithichai Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Bundit Sakulchairungreung Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Goragoch Gesprasert Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Veeravorn Ariyakhagorn Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand/ Bamrungrad International Hospital, Bangkok, Thailand
  • Suthus Sriphojanart Department of surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Keywords:

living donor, liver donor, pediatric liver transplantation, complication

Abstract

Background: Liver transplantation (LT) is the standard treatment for end-stage liver disease, early-stage hepatocellular carcinoma and acute liver failure in adults and children. The shortage of donor organ is a barrier of decease donor LT, resulting in a high waiting-list mortality. Living donor liver transplantation (LDLT) has been performed in Thailand for 20 years to solve this problem.

Objective: We evaluated the clinical outcomes after living donor hepatectomy.

Methods: A retrospective study of living donor who underwent LDLT between 2001 and 2015 was performed. Clavien scoring system was used to grade the severity of complications.

Result: One hundred living donors donated their parts of the livers, left lateral segment or left lobe, to their children. The operation was performed by one operative team. Complications did not occur in 91 donors. The common complications were wound problems (6%), bile leakage (2%) and bile duct injury (1%).Two donors required hospital readmission. Donor mortality is zero in 100 cases.

Conclusions:  Living donor hepatectomy for pediatric recipients was associated with a low complication rate in an experience team.  Good operative planning may decrease the complication rate. 

 

References

Jimenez-Rivera C, Jolin-Dahel KS, Fortinsky KJ, Gozdyra P, Benchimol EI. 1387 international incidence and outcomes of biliary atresia: A systematic review of opultion-ased studiies. J Hepatol. S544-5.

Jimenez-Rivera C, Jolin-Dahel KS, Fortinsky KJ, Gozdyra P, Benchimol EI. International incidence outcomes of biliary atresia. J Pediatr Gastroenterol Nutr. 2013;56:344-54.

Porret PM, Olthoff KM. Current state of living donor liver transplantation. Clinical Liver Disease.2013;2:160-4.

Olthoff KM, Abecassis MM, Emond JC, Kam I, Merion RM, Gillespie BW, et al. Outcomes of adult donor liver transplantation: comparison of the Adult-to-adult Living Donor Liver Transplantation Study and the national experience. Liver Transpl. 2011;17:789-97.

Middleton PF, Duffield M, Lynch SV, Padbury RT, House T, Stanton P, et al. Living donor liver transplantation-adult donor outcomes: a systematic review. Liver Transpl. 2006;12:24-30.

Lo CM. Complications and long-term outcome of living liver donors: a survey of 1,508 cases in five centers. Transplantation. 2003;75:S12-5.

Hashikura Y, Ichida T, Umeshita K, Kawasaki S, Mizokami M, Mochida S, et al. Donor complications associated with living donor liver transplantation in Japan. Transplantation. 2009;88:110-4.

Ueda M, Oike F, Ogura Y, Uryuhara K, Fujimoto Y, Kasahara M, et al. Long-term outcomes of 600 donor liver transplants for pediatric patients at a single center. Liver Transpl. 2006;12:1326-36.

Saidi RF, Elias N, Ko DS, Kawai T, Markmann J, Feng S, et al. Live Donor Partial Hepatectomy for Liver Transplantation: Is There a Learning Curve? Int J Organ Transplant Med. 2010;1:125-30.

Muzaale AD, Dagher NN, Montgomery RA, Taranto SE, McBride MA, Segev DL. Estimates of Early Death, Acute Liver Failure, and Long-term Mortality Among Live Liver Donors. Gastroenterology. 2012;142:273-80.

Wan P, Yu X, Xia Q. Operative outcomes of adult living donor liver transplantation and deceased donor liver transplantation: a systematic review and meta-analysis. Liver Transpl. 2014;20:425-36.

Dindo D, Demartines N, Clavien P-A. Classification of Surgical Complications: A New Proposal With Evaluation in a Cohort of 6336 Patients and Results of a Survey. Annals of Surgery. 2004;240:205-13.

Yamaoka Y, Morimoto T, Inamoto T, Tanaka A, Honda K, Ikai I, et al. Safety of the donor in living-related liver transplantation--an analysis of 100 parental donors. Transplantation. 1995;59:224-6.

Miller CM, Gondolesi GE, Florman S, Matsumoto C, Munoz L, Yoshizumi T, et al. One hundred nine living donor liver transplants in adults and children: a single-center experience. Ann Surg. 2001;234:301-11.

Hwang S, Lee S-G, Lee Y-J, Sung K-B, Park K-M, Kim K-H, et al. Lessons learned from 1,000 living donor liver transplantations in a single center: How to make living donations safe. Liver Transplantation. 2006;12:920-7.

Taketomi A, Morita K, Toshima T, Takeishi K, Kayashima H, Ninomiya M, et al. Living donor hepatectomies with procedures to prevent biliary complications. Journal of the American College of Surgeons. 2010;211:456-64.

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Published

2017-01-06

How to Cite

1.
Arpornsujaritkun N, Leelaudomlipi S, Sobhonslidsuk A, Mingphruedhi S, Jongjirasiri S, Intaraprasong P, Lertsithichai P, Sakulchairungreung B, Gesprasert G, Ariyakhagorn V, Sriphojanart S. Outcome of Living Donor Hepatectomy for Pediatric Liver Transplantation: Report of 100 Cases at Ramathibodi Hospital. Rama Med J [Internet]. 2017 Jan. 6 [cited 2024 Dec. 22];39(4):217-24. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/80454

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Original Articles