Diagnosis and Management of Dementia With Lewy Bodies

Main Article Content

Papan Thaipisuttikul


Daiagnosis of dementia, has been increased especially in the elderly. Dementia with Lewy bodies (DLB), which was formerly believed to have a low incidence, is currently found to be the second most common type of dementia, after Alzheimer's disease. Objectives of this article are to review up-to-date clinical and involved many systems. Also, to help physicians gain more confident on making diagnosis and encourage more awareness on carefully using management method.

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How to Cite
Thaipisuttikul, P. (2014). Diagnosis and Management of Dementia With Lewy Bodies. Ramathibodi Medical Journal, 37(1), 39-47. Retrieved from https://he02.tci-thaijo.org/index.php/ramajournal/article/view/95454
Review Articles


1. Aarsland D, Rongve A, Nore SP, Skogseth R, Skulstad S, Ehrt U, et al. Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria. Dement Geriatr Cogn Disord. 2008;26(5):445-52. doi:10.1159/000165917.

2. Huang Y, Halliday G. Can we clinically diagnose dementia with Lewy bodies yet?. Transl Neurodegener. 2013;2(1):4. doi:10.1186/2047-9158-2-4.

3. McKeith IG. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. J Alzheimers Dis. 2006;9(3 Suppl):417-23.

4. McKeith IG, Perry EK, Perry RH. Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology. 1999;53(5):902-5.

5. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47(5):1113-24.

6. Jellinger KA. Formation and development of Lewy pathology: a critical update. J Neurol. 2009;256 Suppl 3:270-9. doi:10.1007/s00415-009-5243-y.

7. Lopez OL, Litvan I, Catt KE, Stowe R, Klunk W, Kaufer DI, et al. Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias. Neurology. 1999;53(6):1292-9.

8. Ferman TJ, Smith GE, Boeve BF, Ivnik RJ, Petersen RC, Knopman D, et al. DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology. 2004;62(2):181-7.

9. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308-14.

10. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863-72.

11. Dugger BN, Boeve BF, Murray ME, Parisi JE, Fujishiro H, Dickson DW, et al. Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Mov Disord. 2012;27:72-8. doi:10.1002/mds.24003.

12. Aarsland D, Perry R, Larsen JP, McKeith IG, O'Brien JT, Perry EK, et al. Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias. J Clin Psychiatry. 2005;66(5):633-7.

13. Kemp PM, Clyde K, Holmes C. Impact of 123I-FP-CIT (DaTSCAN) SPECT on the diagnosis and management of patients with dementia with Lewy bodies: a retrospective study. Nucl Med Commun. 2011;32(4):298-302. doi:10.1097/MNM.0b013e328343d4ec.

14. Thaipisutikul P, Lobach I, Zweig Y, Gurnani A, Galvin JE. Capgras syndrome in Dementia with Lewy Bodies. Int Psychogeriatr. 2013;25(5):843-849. doi:10.1017/S1041610212002189.

15. Auning E1, Rongve A, Fladby T, Booij J, Hortobágyi T, Siepel FJ, et al. Early and presenting symptoms of dementia with Lewy bodies. Dement Geriatr Cogn Disord. 2011;32(3):202-8. doi:10.1159/000333072.

16. McKeith I1, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet. 2000;356(9247):2031-6.

17. Beversdorf DQ, Warner JL, Davis RA, Sharma UK, Nagaraja HN, Scharre DW. Donepezil in the treatment of dementia with Lewy bodies. Am J Geriatr Psychiatry. 2004;12(5):542-4.

18. Rolinski M, Fox C, Maidment I, McShane R. Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease. Cochrane Database Syst Rev. 2012;(3):CD006504. doi:10.1002/14651858.CD006504.pub2.

19. Aarsland D, Ballard C, Rongve A, Broadstock M, Svenningsson P. Clinical trials of dementia with Lewy bodies and Parkinson's disease dementia. Curr Neurol Neurosci Rep. 2012;12(5):492-501. doi:10.1007/s11910-012-0290-7.

20. Cummings JL, Street J, Masterman D, Clark WS. Efficacy of olanzapine in the treatment of psychosis in dementia with Lewy bodies. Dement Geriatr Cogn Disord. 2002;13(2):67-73.

21. Kurlan R, Cummings J, Raman R, Thal L. Quetiapine for agitation or psychosis in patients with dementia and parkinsonism. Neurology. 2007;68(17):1356-63.

22. Johnell K, Religa D, Eriksdotter M. Differences in drug therapy between dementia disorders in the Swedish dementia registry: a nationwide study of over 7,000 patients. Dement Geriatr Cogn Disord. 2013;35(5-6):239-48. doi:10.1159/000348408.

23. Kim SY, Yoo EY, Jung MY, Park SH, Park JH. A systematic review of the effects of occupational therapy for persons with dementia: a meta-analysis of randomized controlled trials. NeuroRehabilitation. 2012;31(2):107-15. doi:10.3233/NRE-2012-0779.

24. Culo S1, Mulsant BH, Rosen J, Mazumdar S, Blakesley RE, Houck PR, et al. Treating neuropsychiatric symptoms in dementia with Lewy bodies: a randomized controlled-trial. Alzheimer Dis Assoc Disord. 2010;24(4):360-4. doi:10.1097/WAD.0b013e3181e6a4d7.

25. Takahashi S, Mizukami K, Yasuno F, Asada T. Depression associated with dementia with Lewy bodies (DLB) and the effect of somatotherapy. Psychogeriatrics. 2009;9(2):56-61. doi:10.1111/j.1479-8301.2009.00292.x.